A5082573872- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Cardiac Imaging and Diagnostics
- MRI in cancer diagnosis
- Acute Ischemic Stroke Management
- Medical Imaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Advanced NMR Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced Neuroimaging Techniques and Applications
- Coronary Interventions and Diagnostics
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Osteoarthritis Treatment and Mechanisms
- Advanced X-ray and CT Imaging
- Atherosclerosis and Cardiovascular Diseases
- Sparse and Compressive Sensing Techniques
- Medical Image Segmentation Techniques
- Ovarian cancer diagnosis and treatment
- Bone and Joint Diseases
- Intracranial Aneurysms: Treatment and Complications
- Radiation Dose and Imaging
- Body Composition Measurement Techniques
- Photoacoustic and Ultrasonic Imaging
University of Cambridge
2016-2025
Cambridge University Hospitals NHS Foundation Trust
2015-2024
Addenbrooke's Hospital
2015-2024
Cambridge School
2015-2022
Cancer Research UK Cambridge Center
2016-2021
National Health Service
2009-2020
RELX Group (United States)
2020
International Society of Nephrology
2020
Cancer Research UK
2019
Siemens Healthcare (Germany)
2019
Inflammation within atherosclerotic lesions contributes to plaque instability and vulnerability rupture. We set out evaluate the use of a macrophage labeling agent identify carotid inflammation by in vivo magnetic resonance imaging (MRI).Thirty patients with symptomatic severe stenosis scheduled for endarterectomy underwent multi-sequence MRI bifurcation before after injection ultrasmall superparamagnetic particles iron oxide (USPIOs). USPIO accumulated macrophages 24 30 plaques (80%). Areas...
Our purpose is to investigate the feasibility of imaging tumor metabolism in breast cancer patients using 13 C magnetic resonance spectroscopic (MRSI) hyperpolarized label exchange between injected [1- C]pyruvate and endogenous lactate pool. Treatment-naïve were recruited: four triple-negative grade 3 cancers; two invasive ductal carcinomas that estrogen progesterone receptor-positive (ER/PR+) HER2/neu-negative (HER2−), one 2 3; ER/PR+ HER2− lobular carcinoma (ILC). Dynamic MRSI was...
Hyperpolarized 13C Magnetic Resonance Imaging (13C-MRI) provides a highly sensitive tool to probe tissue metabolism in vivo and has recently been translated into clinical studies. We report the cerebral of intravenously injected hyperpolarized [1–13C]pyruvate brain healthy human volunteers for first time. Dynamic acquisition images demonstrated 13C-labeling both lactate bicarbonate, catalyzed by cytosolic dehydrogenase mitochondrial pyruvate respectively. This demonstrates that enzymes can...
Background— It has been suggested that inflammatory cells within vulnerable plaques may be visualized by superparamagnetic iron oxide particle-enhanced MRI. The purpose of this study was to determine the time course for macrophage visualization with in vivo contrast-enhanced MRI using an ultrasmall (USPIO) agent symptomatic human carotid disease. Methods— Eight patients scheduled endarterectomy underwent multisequence bifurcation before and 24, 36, 48, 72 hours after Sinerem (2.6 mg/kg)...
Background and Purpose— Carotid endarterectomy is currently guided by angiographic appearance on the assumption that most stenotic lesion visible at angiography likely to be from which future embolic events will arise. However, risk of plaque rupture, common cause atherosclerosis-related thromboembolism, dictated composition plaque, in particular degree inflammation. Angiography may, therefore, an unreliable method identifying vulnerable plaques. In this study, inflammation was quantified...
Cardiovascular magnetic resonance (CMR) allows non-invasive phase contrast measurements of flow through planes transecting large vessels. However, some clinically valuable applications are highly sensitive to errors caused by small offsets measured velocities if these not adequately corrected, for example the use static tissue or phantom correction offset error. We studied severity uncorrected velocity across sites and CMR systems. In a multi-centre, multi-vendor study, breath-hold...
Magnetic resonance (MR) first-pass myocardial perfusion imaging during hyperaemia detects coronary artery stenoses in humans with test sensitivity depending on contrast medium (CM)-induced signal change myocardium. In this prospective multi-centre study, the effect of CM dose and diagnostic performance was evaluated using a stress-only approach.Ninety-four patients known or suspected disease (CAD) were randomised to 0.05,0.10, 0.15 mmol/kg body weight an extravascular (Gd-DTPA) X-ray...
T1 mapping and extracellular volume (ECV) have the potential to guide patient care serve as surrogate end-points in clinical trials, but measurements differ between cardiovascular magnetic resonance (CMR) scanners pulse sequences. To help deliver global care, we developed a phantom-based quality assurance (QA) system for verification of measurement stability over time at individual sites, with further aims generalization results across vendor systems, software versions imaging We thus...
Dissolution dynamic nuclear polarization (DNP) enables the metabolism of hyperpolarized 13 C‐labelled molecules, such as conversion [1‐ C]pyruvate to C]lactate, be dynamically and non‐invasively imaged in tissue. Imaging this exchange reaction animal models has been shown detect early treatment response correlate with tumour grade. The first human DNP study recently completed, and, for widespread clinical translation, simple reliable methods are necessary accurately probe patients. However,...
Deuterium metabolic imaging (DMI) and hyperpolarized 13C-pyruvate MRI (13C-HPMRI) are two emerging methods for non-invasive non-ionizing of tissue metabolism. Imaging cerebral metabolism has potential applications in cancer, neurodegeneration, multiple sclerosis, traumatic brain injury, stroke, inborn errors Here we directly compare these at 3 T the first time humans show how they simultaneously probe both oxidative non-oxidative DMI was undertaken 1–2 h after oral administration...
Abstract Hyperpolarised magnetic resonance imaging (HP 13 C-MRI) is an emerging clinical technique to detect [1- C]lactate production in prostate cancer (PCa) following intravenous injection of hyperpolarised C]pyruvate. Here we differentiate clinically significant PCa from indolent disease a low/intermediate-risk population by correlating labelling on MRI with the percentage Gleason pattern 4 (%GP4) disease. Using immunohistochemistry and spatial transcriptomics, show that HP C-MRI...
Assessing inflammatory disease activity in large vessel vasculitis (LVV) can be challenging by conventional measures. We aimed to investigate somatostatin receptor 2 (SST2) as a novel inflammation-specific molecular imaging target LVV. In prospective, observational cohort study, vivo arterial SST2 expression was assessed positron emission tomography/magnetic resonance (PET/MRI) using 68Ga-DOTATATE and 18F-FET-βAG-TOCA. Ex mapping of the performed immunofluorescence microscopy; mass...
Differentiating aggressive clear cell renal carcinoma (ccRCC) from indolent lesions is challenging using conventional imaging. This work prospectively compared the metabolic imaging phenotype of tumors carbon-13 MRI following injection hyperpolarized [1-
To evaluate the impact of a commercially available deep learning-based reconstruction (DLR) algorithm with varying combinations DLR noise reduction settings and imaging parameters on quantitative qualitative image quality, PI-RADS classification examination time in prostate T2-weighted (T2WI) diffusion-weighted (DWI) imaging.Forty patients were included. Standard-of-care (SoC) MRI sequences including T2WI DWI reconstructed without different de-noising levels (low, medium, high). In addition,...