A5063303269- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Hemoglobinopathies and Related Disorders
- Cardiomyopathy and Myosin Studies
- Iron Metabolism and Disorders
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Lysosomal Storage Disorders Research
- Viral Infections and Immunology Research
- Cardiac Arrhythmias and Treatments
- Advanced NMR Techniques and Applications
- Congenital Heart Disease Studies
- Ultrasound and Hyperthermia Applications
- Cardiovascular Disease and Adiposity
- Coronary Interventions and Diagnostics
- Cardiac tumors and thrombi
- Acute Myocardial Infarction Research
- Pericarditis and Cardiac Tamponade
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Electron Spin Resonance Studies
IRCCS Policlinico San Donato
2016-2025
Alexander Fleming Biomedical Sciences Research Center
2024
IRCCS Humanitas Research Hospital
2024
Humanitas University
2024
Ospedale Antonio Cardarelli
2023
University of Molise
2023
University Hospital in Halle
2023
Azienda Ospedaliero-Universitaria di Modena
2023
Istituto di Fisiologia Clinica
2008-2022
Lombardia Informatica (Italy)
2022
Hypertrophic cardiomyopathy (HCM) is the most common cause of sudden death in young, although not all patients eligible for prevention with an implantable cardioverter-defibrillator are identified. Contrast-enhanced cardiovascular magnetic resonance late gadolinium enhancement (LGE) has emerged as vivo marker myocardial fibrosis, its role stratifying risk subgroups HCM remains incompletely understood.We assessed relation between LGE and outcomes 1293 referred followed up a median 3.3 years....
To determine in a multicentre, multivendor trial the diagnostic performance for perfusion-cardiac magnetic resonance (perfusion-CMR) comparison with coronary X-ray angiography (CXA) and single-photon emission computed tomography (SPECT). Of 241 eligible patients from 18 centres, 234 were randomly dosed 0.01, 0.025, 0.05, 0.075, or 0.1 mmol/kg Gd-DTPA-BMA (Omniscan™, GE-Healthcare) per stress (0.42 mg/kg adenosine) rest perfusion study. Coronary artery disease (CAD) was defined as diameter...
Background— The choice of imaging techniques in patients with suspected coronary artery disease (CAD) varies between countries, regions, and hospitals. This prospective, multicenter, comparative effectiveness study was designed to assess the relative accuracy commonly used for identifying significant CAD. Methods Results— A total 475 stable chest pain intermediate likelihood CAD underwent computed tomographic angiography stress myocardial perfusion by single photon emission tomography or...
The EuroCMR registry sought to evaluate indications, image quality, safety and impact on patient management of clinical routine CMR in a multi-national European setting. Furthermore, interim analysis the specific protocols should underscore prognostic potential CMR. Multi-center with consecutive enrolment patients 57 centers 15 countries. More than 27000 were enrolled. most important indications risk stratification suspected CAD/Ischemia (34.2%), workup myocarditis/cardiomyopathies (32.2%),...
The term 'athlete's heart' refers to a clinical picture characterized by slow heart rate and enlargement of the heart. A multi-modality imaging approach athlete's aims differentiate physiological changes due intensive training in from serious cardiac diseases with similar morphological features. Imaging assessment should begin thorough echocardiographic examination.Left ventricular (LV) wall thickness echocardiography can contribute distinction between LV hypertrophy hypertrophic...
Accurate risk stratification for patients with non-dilated left ventricular cardiomyopathy (NDLVC) remains challenging due to lack of dedicated clinical trials. This post-hoc analysis aims delineate the arrhythmic and assess incremental value cardiac magnetic resonance (CMR) imaging in DERIVATE (CarDiac MagnEtic Resonance Primary Prevention Implantable CardioVerter DebrillAtor ThErapy) study cohort meeting NDLVC diagnostic criteria. Patients from registry were identified absence (LV)...
Preferential visceral adipose tissue (VAT) deposition has been associated with the presence of insulin resistance in obese and diabetic subjects. The independent association VAT accumulation hypertension its impact on sensitivity β-cell function have not assessed. We measured subcutaneous fat depots by multiscan MRI 13 nondiabetic men newly detected, untreated essential (blood pressure=151±2/94±2 mm Hg, age=47±2 years, body mass index [BMI]=28.4±0.7 kg · m −2 ) 26 age-matched BMI-matched...
Cardiovascular magnetic resonance (CMR) allows non-invasive phase contrast measurements of flow through planes transecting large vessels. However, some clinically valuable applications are highly sensitive to errors caused by small offsets measured velocities if these not adequately corrected, for example the use static tissue or phantom correction offset error. We studied severity uncorrected velocity across sites and CMR systems. In a multi-centre, multi-vendor study, breath-hold...
Abstract Purpose To assess the tissue iron concentration of left ventricle (LV) using a multislice, multiecho T2* MR technique and segmental analysis. Materials Methods MRI was performed in 53 thalassemia major patients. Three short‐axis views LV were obtained analyzed with custom‐written software. The myocardium automatically segmented into 12 segments. value on each segment as well global calculated. Cine dynamic images also to evaluate biventricular function parameters by quantitative...
To assess the intricate relationship between myocardial infarction (MI) location and size their reciprocal influences on post-infarction left ventricular (LV) remodelling. A cohort of 260 reperfused ST-segment elevation MI patients was prospectively studied with cardiovascular magnetic resonance at 1 week (baseline) 4 months (follow-up). Area risk (AAR) were quantified by T2-weighted late-gadolinium enhancement imaging, respectively. Adverse LV remodelling defined as an increase in...
Background— In idiopathic dilated cardiomyopathy, there are scarce data on the influence of late gadolinium enhancement (LGE) assessed by cardiovascular magnetic resonance left ventricular (LV) remodeling. Methods and Results— Fifty-eight consecutive patients with cardiomyopathy underwent baseline clinical, biohumoral, instrumental workup. Medical therapy was optimized after study enrollment. Cardiovascular used to assess volumes, function, LGE extent at 24-month follow-up. LV reverse...
Due to the limited data available in literature, aim of this multi-centre study was prospectively compare thalassemia major (TM) patients efficacy combined deferiprone (DFP) and deferoxamine (DFO) regimen versus either DFP DFO monotherapy by cardiovascular magnetic resonance (CMR) over a follow up 18 months. Among first 1135 TM MIOT (Myocardial Iron Overload Thalassemia) network, we evaluated those who had received (DFO + DFP, N=51) or (N=39) (N=74) monotherapies between two CMR scans....
Hybrid imaging provides a non-invasive assessment of coronary anatomy and myocardial perfusion. We sought to evaluate the added clinical value hybrid in multi-centre multi-vendor setting.Fourteen centres enrolled 252 patients with stable angina intermediate (20-90%) pre-test likelihood artery disease (CAD) who underwent perfusion scintigraphy (MPS), CT angiography (CTCA), quantitative (QCA) fractional flow reserve (FFR). MPS/CTCA images were obtained by 3D image fusion. Blinded core-lab...
Background— We conducted a prospective longitudinal study to investigate the yet unknown clinical significance of myocardial fibrosis in patients with non–ischemic cardiomyopathy without history congestive heart failure (CHF). Methods and Results— At 3 tertiary referral centers, 228 CHF were studied cardiovascular magnetic resonance for late gadolinium enhancement (LGE) detection quantification prospectively followed up median 23 months. The end point was composite cardiac death, onset CHF,...
Purpose To define reference values of cardiac volumes, dimensions, and new morpho‐functional parameters normalized for age, gender, body surface area by cine‐bSSFP (balanced steady‐state free‐precession) magnetic resonance (MR). Materials Methods We enrolled 308 healthy subjects subdivided gender six age classes: class I, >15–20 years; II, >20–30 III, >30–40 IV, >40–50 V, >50–60 VI >60 years. Dimensional, volumetric the left (LV) right (RV) ventricles were measured using...