A5010606798- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Extracellular vesicles in disease
- Neonatal Respiratory Health Research
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Periodontal Regeneration and Treatments
- Immune cells in cancer
- Neonatal Health and Biochemistry
- Retinopathy of Prematurity Studies
- Osteoarthritis Treatment and Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Mesenchymal stem cell research
- Folate and B Vitamins Research
- Tendon Structure and Treatment
- Colorectal and Anal Carcinomas
- Oral health in cancer treatment
- Endometriosis Research and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Grief, Bereavement, and Mental Health
- Head and Neck Cancer Studies
- Bone and Joint Diseases
- European Law and Migration
- Cancer Treatment and Pharmacology
- Sexual function and dysfunction studies
Casa Sollievo della Sofferenza
2014-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2011-2025
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2022
Azienda ospedaliera "Bianchi-Melacrino-Morelli"
2022
Agostino Gemelli University Polyclinic
2022
GTx (United States)
2020
University of Foggia
2007-2008
University of Bari Aldo Moro
2006
Due to the limited data available in literature, aim of this multi-centre study was prospectively compare thalassemia major (TM) patients efficacy combined deferiprone (DFP) and deferoxamine (DFO) regimen versus either DFP DFO monotherapy by cardiovascular magnetic resonance (CMR) over a follow up 18 months. Among first 1135 TM MIOT (Myocardial Iron Overload Thalassemia) network, we evaluated those who had received (DFO + DFP, N=51) or (N=39) (N=74) monotherapies between two CMR scans....
// Luciana De Luca 1 , Stefania Trino Ilaria Laurenzana Vittorio Simeon Giovanni Calice Raimondo 2 Marina Podestà 3 Michele Santodirocco 4 Lazzaro Di Mauro Francesco La Rocca Antonella Caivano Annalisa Morano Frassoni 5 Daniela Cilloni Luigi Del Vecchio 6, 7, * Pellegrino Musto 8, Laboratory of Preclinical and Translational Research, IRCCS-Centro di Riferimento Oncologico della Basilicata (CROB), Rionero in Vulture, 85028, Italy Department Clinical Biological Sciences, University...
Summary The relationship between diabetes mellitus ( DM ) and cardiac complications has never been systematically studied in thalassaemia major TM ). We evaluated a large retrospective historical cohort of to determine whether is associated with higher risk heart complications. compared 86 patients affected by 709 without consecutively included the Myocardial Iron Overload Thalassaemia database where clinical/instrumental data are recorded from birth first cardiovascular magnetic resonance...
In addition to a largely prevalent use for bleeding prophylaxis, platelet concentrates from adult blood have also been used many years prepare gels the repair of topical skin ulcers. Platelet gel can be obtained by activation fresh, cryopreserved, autologous or allogeneic with calcium gluconate, thrombin and/or batroxobin. The high content tissue regenerative factors in cord platelets and widespread availability units generously donated haematopoietic transplant but unsuitable this solely...
Abstract Background Extremely low gestational age neonates (ELGANs, i.e., born before 28 weeks of gestation) are at high risk developing retinopathy prematurity (ROP), with potential long-life visual impairment. Due to concomitant anemia, ELGANs need repeated red blood cell (RBC) transfusions. These produce a progressive replacement fetal hemoglobin (HbF) by adult (HbA). Furthermore, close association exists between levels HbF and severe ROP, suggesting that perturbation the HbF-mediated...
Objectives: This study aimed to compare the pancreatic volume between beta-thalassemia major (β-TM) and intermedia (β-TI) patients thalassemia healthy subjects determine predictors of its association with glucose metabolism in β-TM β-TI patients. Methods: We considered 145 19 enrolled E-MIOT project 20 subjects. The hepatic iron levels were quantified by magnetic resonance imaging. Results: indexed body surface area (PVI) was significantly lower both compared only independent determinants...
Abstract Umbilical cord blood (UCB) contains hematopoietic stem cells and multipotent mesenchymal useful for treatment in malignant/nonmalignant hematologic-immunologic diseases regenerative medicine. Transplantation outcome is correlated with volume (CBV), number of total nucleated (TNC), CD34+ progenitor colony forming units UCB donations. Several studies have addressed the role maternal/neonatal factors associated reconstruction potential UCB, including: gestational age, maternal parity,...
Acute myeloid leukemia (AML) is an aggressive and heterogeneous clonal disorder of hematopoietic stem/progenitor cells (HSPCs). It not well known how alter hematopoiesis promoting tumor growth leukemic niche formation. In this study, we investigated AML deregulates the process HSPCs through release extracellular vesicles (EVs). First, found that released a population EVs containing microRNAs involved in pathogenesis. Notably, AML-EVs were able to influence fate modifying their transcriptome....
We investigated the prevalence, clinical characteristics, and prognostic role of dilated cardiomyopathy (DCM) non-dilated left ventricular (NDLVC) in patients with transfusion-dependent β-thalassemia (β-TDT). retrospectively included 415 β-TDT who underwent cardiovascular magnetic resonance to quantify myocardial iron overload (MIO) biventricular function parameters detect replacement fibrosis. Demographic laboratory were comparable among no overt (NOCM; n = 294), DCM (n 12), NDLVC 109),...
Acute Myeloid Leukemia (AML) cells communicate with surrounding normal cells, including hematopoietic stem progenitor (HSPCs), in the bone marrow, and modify their fate supporting tumor growth. This communication can be mediated by Extracellular Vesicles (EVs), small vectors carrying a range of molecular information. One hallmarks AML is aberrant DNA methylation. It not known if how epigenomic profile healthy HSPCs. Here, we investigated methylation HSPCs after exposure to derived-EVs. Cord...
Platelet gel from cord blood (CBPG) is a recently developed component for topical use. We report case of life-threatening mucositis after high-dose chemotherapy with fotemustine and cytarabine that was successfully treated CBPG.A patient non-Hodgkin lymphoma who undergoing autologous hematopoietic stem cell transplantation severe oral esophageal bacterial sepsis cytomegalovirus infection, causing prolonged neutropenia. CBPG topically administered daily to the cavity. The partially reabsorbed...
Cord blood platelet gel is prepared by activation of coagulation in a concentrate obtained from cord blood. During the process clot formation, alpha-granules release growth factors that promote tissue repair. However, form gel, it not possible to inject into small, narrow and deep cavities. Therefore, we analyzed gelification kinetics developed an application technique liquid form. This semi-activated provides for but concentrate. In this way, can be easily inoculated endocavitary space,...
<p><strong>Aim <br /></strong>To investigate the role of cordonal blood platelet-rich plasma (PRP) intra-articular injections for treating patients with knee<br />osteoarthritis in terms procedure safety and clinical outcomes.<br /><strong>Methods /></strong>Twenty-five affected by knee osteoarthritis were enrolled received one single injection of<br...
The aim of this study was to analyse umbilical cord blood (UCB) collection over 1 year between October 2008 and September 2009, seeking ways improve the number suitable banked UCB units. Four phases process were investigated, from consent form banking procedure, paying attention discarded units.We recruited couples at 35 weeks gestation took an accurate history, focusing on genetic, immunological infectious diseases. We collected pregnant women who delivered vaginally or by Caesarean section...
Multiple myeloma (MM) is characterized by the abnormal proliferation of clonal plasma cells (PCs) in bone marrow (BM). MM-PCs progressively occupy and likely alter BM niches where reside hematopoietic stem progenitor (HSPCs) whose viability, self-renewal, proliferation, commitment, differentiation are essential for normal hematopoiesis. Extracellular vesicles (EVs) particles released neoplastic cells, such as MM cells. They important cell-to-cell communicators able to modify phenotype,...
<i>Background:</i> Nevirapine (NVP) is a nonnucleoside reverse transcriptase inhibitor used in HIV patients and recently evaluated as differentiating antiproliferative agent human malignancies. However, while NVP safe treatment immunocompromised patients, NVP-containing regimens have been associated with severe immune-mediated toxicities non-HIV individuals. <i>Methods Results:</i> We describe the toxicity profile of single-agent 6 cancer treated for median period 7.3...