Leonardo Mejia Rincon
A5073886328- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiomyopathy and Myosin Studies
- Venous Thromboembolism Diagnosis and Management
- Robotic Mechanisms and Dynamics
- Acute Myocardial Infarction Research
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Lipoproteins and Cardiovascular Health
- Cardiovascular Effects of Exercise
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 Clinical Research Studies
- Frailty in Older Adults
- Antiplatelet Therapy and Cardiovascular Diseases
- Advanced X-ray and CT Imaging
- Cardiac Health and Mental Health
- Robot Manipulation and Learning
- Cardiac, Anesthesia and Surgical Outcomes
- Infective Endocarditis Diagnosis and Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Heart Failure Treatment and Management
- Long-Term Effects of COVID-19
- Plant Disease Resistance and Genetics
Centro de Investigación Biomédica en Red
2019-2025
Centro de Investigación en Red en Enfermedades Cardiovasculares
2017-2025
Instituto de Investigación Biomédica de Salamanca
2022-2025
Universidad de Salamanca
2021-2025
Instituto de Salud Carlos III
2017-2025
Fundación Santa Fe de Bogotá
2025
SEQUOIA (Italy)
2024
Universidade Federal de Santa Catarina
2017-2024
Complejo Hospitalario de Salamanca
2021-2024
Sequoia (United States)
2024
Background— The choice of imaging techniques in patients with suspected coronary artery disease (CAD) varies between countries, regions, and hospitals. This prospective, multicenter, comparative effectiveness study was designed to assess the relative accuracy commonly used for identifying significant CAD. Methods Results— A total 475 stable chest pain intermediate likelihood CAD underwent computed tomographic angiography stress myocardial perfusion by single photon emission tomography or...
Hybrid imaging provides a non-invasive assessment of coronary anatomy and myocardial perfusion. We sought to evaluate the added clinical value hybrid in multi-centre multi-vendor setting.Fourteen centres enrolled 252 patients with stable angina intermediate (20-90%) pre-test likelihood artery disease (CAD) who underwent perfusion scintigraphy (MPS), CT angiography (CTCA), quantitative (QCA) fractional flow reserve (FFR). MPS/CTCA images were obtained by 3D image fusion. Blinded core-lab...
Despite being associated with worse prognosis in patients COVID-19, systematic determination of myocardial injury is not recommended. The aim the study was to effect assessment on risk stratification COVID-19 patients.Seven hundred seven consecutive adult admitted a large tertiary hospital confirmed were included. Demographic data, comorbidities, laboratory results and clinical outcomes recorded. Charlson comorbidity index (CCI) calculated order quantify degree comorbidities. Independent...
Background Aficamten, a novel cardiac myosin inhibitor, reversibly reduces hypercontractility in obstructive hypertrophic cardiomyopathy. We present prespecified analysis of the pharmacokinetics, pharmacodynamics, and safety aficamten SEQUOIA‐HCM (Safety, Efficacy, Quantitative Understanding Obstruction Impact Aficamten HCM). Methods Results A total 282 patients with cardiomyopathy were randomized 1:1 to daily (5–20 mg) or placebo between February 1, 2022, May 15, 2023. dosing targeted...
Importance Impaired exercise capacity is a cardinal manifestation of obstructive hypertrophic cardiomyopathy (HCM). The Phase 3 Trial to Evaluate the Efficacy and Safety Aficamten Compared Placebo in Adults With Symptomatic Obstructive HCM (SEQUOIA-HCM) pivotal study characterizing treatment effect aficamten, next-in-class cardiac myosin inhibitor, on comprehensive set performance clinical measures. Objective To evaluate aficamten using cardiopulmonary testing with novel integrated measure...
Background Acute coronary syndrome ( ACS ) patients are increasingly older. Conventional prognostic scales include chronological age but do not consider vulnerability. In elderly patients, a frail phenotype represents better reflection of biological age. Hypothesis: This study aims to determine the prevalence frailty and its influence on ≥75 years with ACS. Methods Patients admitted due type 1 myocardial infarction were included in 2 tertiary hospitals, clinical data collected prospectively....
Background Swirling flow, organized in vortices, contributes to adequate left ventricular function. In this study, we apply a novel echocardiographic flow‐mapping technique, vector flow mapping ( VFM ), evaluate the main characteristics of vortices and its relation filling parameters. Methods Forty‐eight subjects underwent conventional transthoracic examination with additional intracardiac assessment using Aloka Alpha‐10 system experimental analysis software. To analyze vortex behavior,...
<b><i>Background:</i></b> Myocardial infarction (MI) patients are increasingly older, and common risk scores include chronological age, but do not consider chronic comorbidity or biological age. Frailty status reflects these variables may be independently correlated with prognosis in this setting. <b><i>Objective:</i></b> This study investigated the impact of frailty on elderly admitted due to MI. <b><i>Methods:</i></b>...
Abstract Background Patients with acute myocardial infarction (MI) are at high risk of upcoming events, in particular heart failure (HF), but reliable stratification methods lacking. Our goal was to evaluate the potential role circulating miRNAs as prognostic biomarkers patients presenting MI. Methods and results We conducted a prospective study among 311 consecutive hospitalized MI (65% ST‐segment elevation & median age 55 years) long‐term follow‐up. An initial screening select...
Abstract Background and Aims Patients with obstructive hypertrophic cardiomyopathy (oHCM) treated aficamten in SEQUOIA-HCM (NCT05186818) demonstrated marked improvement symptoms functional capacity. This analysis explores whether oHCM mild experience similar clinical benefit as patients more advanced limitation. Methods (N=282) were grouped at baseline according to symptom severity. Mild (n=118) defined New York Heart Association (NYHA) class II Kansas City Cardiomyopathy Questionnaire...
3D transesophageal echocardiography (TEE) is superior to 2D TEE in quantitative anatomic evaluation of the mitral valve (MV) but it shows limitations regarding automatic quantification. Here, we tested inter-/intra-observer reproducibility a novel full-automated software MV anatomy compared manual assessment.Thirty-six out 61 screened patients referred our Cardiac Imaging Unit for were retrospectively included. analysis was performed both manually and with automated by two independent...
Aim: To analyze the frequency and variables related to inappropriate rivaroxaban dosage in clinical practice its impact on outcomes after 2 years. Materials & methods: Postauthorization, observational, multicenter study, which atrial fibrillation patients, treated with ≥6 months were included. Results: A total of 1421 patients (74.2 ± 9.7 years, CHA2DS2-VASc 3.5 1.6) Overall, 22.9% received 15 mg. The proper dose was taken by 83.3% (9.7% underdosed, 7.0% overdosed). Older age renal...