A5071661523- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Advanced X-ray and CT Imaging
- Acute Myocardial Infarction Research
- Advanced MRI Techniques and Applications
- Coronary Artery Anomalies
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Radiation Dose and Imaging
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Cardiovascular Disease and Adiposity
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Lymphoma Diagnosis and Treatment
- Cardiomyopathy and Myosin Studies
- Cardiac Arrhythmias and Treatments
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Kawasaki Disease and Coronary Complications
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Ultrasound Imaging and Elastography
- Infective Endocarditis Diagnosis and Management
Leiden University Medical Center
2013-2024
Leiden University
2012-2022
Medisch Centrum Haaglanden
2019
Netherlands Heart Institute
2013-2016
Istituto di Fisiologia Clinica
2015-2016
Scuola Superiore Sant'Anna
2016
Azienda Ospedaliera Universitaria Pisana
2016
Fondazione Toscana Gabriele Monasterio
2016
Vall d'Hebron Hospital Universitari
2016
Turku University Hospital
2016
Background— The choice of imaging techniques in patients with suspected coronary artery disease (CAD) varies between countries, regions, and hospitals. This prospective, multicenter, comparative effectiveness study was designed to assess the relative accuracy commonly used for identifying significant CAD. Methods Results— A total 475 stable chest pain intermediate likelihood CAD underwent computed tomographic angiography stress myocardial perfusion by single photon emission tomography or...
Hybrid imaging provides a non-invasive assessment of coronary anatomy and myocardial perfusion. We sought to evaluate the added clinical value hybrid in multi-centre multi-vendor setting.Fourteen centres enrolled 252 patients with stable angina intermediate (20-90%) pre-test likelihood artery disease (CAD) who underwent perfusion scintigraphy (MPS), CT angiography (CTCA), quantitative (QCA) fractional flow reserve (FFR). MPS/CTCA images were obtained by 3D image fusion. Blinded core-lab...
The purpose of the study was to systematically compare calcification patterns in plaques on computed tomography angiography (CTA) with plaque characteristics intravascular ultrasound radiofrequency backscatter analysis (IVUS-VH).
Objective— Circulating levels of high-sensitivity cardiac troponin T (hs-cTnT) and N terminal pro brain natriuretic peptide (NT-proBNP) are predictors prognosis in patients with coronary artery disease (CAD). We aimed at evaluating the effect atherosclerosis myocardial ischemia on release hs-cTnT NT-proBNP suspected CAD. Approach Results— Hs-cTnT were measured 378 (60.1±0.5 years, 229 males) stable angina unknown CAD enrolled Evaluation Integrated Cardiac Imaging (EVINCI) study. All...
Prognostic importance of coronary vessel dominance in patients with ST-elevation myocardial infarction (STEMI) remains uncertain. The aim this study was to assess influence on the short- and long-term outcome after STEMI.Coronary angiographic images consecutive presenting first STEMI were retrospectively reviewed dominance. Patients followed during a median period 48 (IQR38-61) months for occurrence all-cause mortality composite reinfarction cardiac death. population comprised 1131 which 971...
An automatic coronary artery tree labeling algorithm is described to identify the anatomical segments of extracted centerlines from computed tomography angiography (CCTA) images. This method will facilitate lesion reporting and risk stratification cardiovascular disease. Three-dimensional (3D) models for both right dominant (RD) left (LD) circulations were built. All labels in model matched with their possible candidates find optimal result. In total, 83 CCTA datasets 1149 included testing...
To enhance risk stratification in patients suspected of coronary artery disease, the assessment calcium (CAC) could be incorporated, especially when CAC can readily assessed on previously performed non-gated chest computed tomography (CT). Guidelines recommend reporting patients' extent these non-cardiac directed exams and various studies have shown diagnostic prognostic value. However, this method is still little applied, no current consensus exists clinical practice. This review aims to...
The aim of this study was to assess the impact adding stress computed tomography (CT) myocardial perfusion (CTP) coronary CT angiography (CTA) on downstream referral for invasive (ICA), revascularization, and outcome in patients presenting with new-onset chest pain.Three hundred eighty-four were referred cardiac CT. Patients lesions ≥50% stenosis underwent subsequently CTP. Perfusion scans considered abnormal if a defect observed ≥ 1 segment. Downstream performance ICA, occurrence major...
<h3>Objective</h3> Variable coronary anatomy has been described in patients with bicuspid aortic valves (BAVs). This was never specified to BAV morphology, and prognostic relevance of vessel dominance this patient group is unclear. The purpose study evaluate valve morphology relation artery outcome isolated associated coarctation (CoA). <h3>Methods</h3> Coronary evaluated 186 (141 men (79%), 51±14 years) by CT invasive angiography. Correlation made events. <h3>Results</h3> Strictly (without...
To determine the implications of stable coverage coronary ostia by Edwards SAPIEN valve frame in terms myocardial ischemia and subsequent percutaneous intervention (PCI), following transcatheter aortic implantation (TAVI).Edwards is frequently deployed relatively higher than recommended may overlap ostia.A total 142 patients (age 81 ± 7 years, male 49%) treated with multi-detector row computed tomography at 1 month follow-up were evaluated. The position relation to was assessed. Levels...
Diabetic patients with coronary artery disease (CAD) are often free of chest pain syndrome. A useful modality for non-invasive assessment CAD is computed tomography angiography (CTA). However, the prognostic value on CTA in diabetic without syndrome relatively unknown. Therefore, aim was to investigate long-term a large population Between 2005 and 2013, 525 were prospectively included undergo calcium (CAC)-scoring followed by CTA. During follow-up, composite endpoint all-cause mortality,...
Aberrant origin of the coronary arteries is rare but can be life threatening. It an important cause sudden death in athletes and other young adults, may treated surgically. Consensus exists that interarterial left artery (LCA) should surgically repaired. For right (RCA), discussion remains open. The purpose this study was to analyse our surgical experience.From 2001 until 2014, 31 patients were operated for RCA, LCA or intraseptal course LCA. Twenty-six had 4 1 patient Median age at...
We enhance intravascular ultrasound virtual histology (VH) tissue characterization by fully automatic quantification of the acoustic shadow behind calcified plaque. VH is unable to characterize atherosclerosis located calcifications. In this study, quantified shadows are considered approximate real dense calcium (DC) plaque volume. total, 57 patients with 108 coronary lesions were included. A novel post-processing step applied on images quantify and results. The enhanced results compared...
Given current pretest probability (PTP) estimations tend to overestimate patients' risk for obstructive coronary artery disease, evaluation of calcium (CAC) is more precise. The value CAC assessment with the Agatston score on cardiac computed tomography (CT) estimation has been well indicated in patients stable chest pain. can be equally assessed routine non-gated CT, which often available. This study aims determine clinical applicability CT pain compared classic gated CT. Consecutive...
Guidelines recommend standard pre-operative cardiac screening in all liver transplantation (LT) recipients, despite the relatively low prevalence of obstructive coronary artery disease. Most LT recipients often have non-gated computed tomography (CT) performed chest and abdomen. This study evaluated ability calcification (CAC) assessment on consecutively available scans, to identify a selection low-risk patients, whom further imaging can be safely withheld.
CT angiography (CTA) and SPECT myocardial perfusion imaging (MPI) are complementary techniques to assess coronary artery disease (CAD). Spatial integration combined visualization of MPI CTA data may facilitate correlation defects subtending arteries thus offer additional diagnostic value over either stand-alone or side-by-side interpretation the respective datasets from 2 modalities. In this study, we investigated a software-based CTA/SPECT image fusion system conventional analysis in...
Coronary-computed tomography angiography (CTA) has limited accuracy to predict myocardial ischemia. Besides luminal area stenosis, other coronary plaque morphology and composition parameters may help assess With the integration of CTA adenosine stress CT perfusion (CTP), reliable information regarding anatomy function can be derived in one procedure. This analysis aimed investigate association between stenosis severity, presence ischemia measured with CTP. 84 patients (age, 62 ± 10 years;...