Giancarlo Todiere
A5025205077- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Cardiovascular Effects of Exercise
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Viral Infections and Immunology Research
- Cardiac electrophysiology and arrhythmias
- Pericarditis and Cardiac Tamponade
- Cardiac Arrhythmias and Treatments
- Genetic Neurodegenerative Diseases
- Systemic Sclerosis and Related Diseases
- Cardiac Valve Diseases and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Disease and Adiposity
- Lanthanide and Transition Metal Complexes
- Infective Endocarditis Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Acute Myocardial Infarction Research
- Vasculitis and related conditions
- Sports injuries and prevention
- Congenital Heart Disease Studies
- Renal and Vascular Pathologies
Fondazione Toscana Gabriele Monasterio
2016-2025
Regione Toscana
2016-2025
Ospedale di Cattinara
2023-2025
Azienda Ospedaliero Universitaria Ospedali Riuniti
2023
University of Pisa
2011-2023
Scuola Superiore Sant'Anna
2010-2023
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
2023
Istituto di Fisiologia Clinica
2010-2019
KU Leuven
2010-2019
University of Leeds
2016
Background— The choice of imaging techniques in patients with suspected coronary artery disease (CAD) varies between countries, regions, and hospitals. This prospective, multicenter, comparative effectiveness study was designed to assess the relative accuracy commonly used for identifying significant CAD. Methods Results— A total 475 stable chest pain intermediate likelihood CAD underwent computed tomographic angiography stress myocardial perfusion by single photon emission tomography or...
Accurate risk stratification for patients with non-dilated left ventricular cardiomyopathy (NDLVC) remains challenging due to lack of dedicated clinical trials. This post-hoc analysis aims delineate the arrhythmic and assess incremental value cardiac magnetic resonance (CMR) imaging in DERIVATE (CarDiac MagnEtic Resonance Primary Prevention Implantable CardioVerter DebrillAtor ThErapy) study cohort meeting NDLVC diagnostic criteria. Patients from registry were identified absence (LV)...
Background— In idiopathic dilated cardiomyopathy, there are scarce data on the influence of late gadolinium enhancement (LGE) assessed by cardiovascular magnetic resonance left ventricular (LV) remodeling. Methods and Results— Fifty-eight consecutive patients with cardiomyopathy underwent baseline clinical, biohumoral, instrumental workup. Medical therapy was optimized after study enrollment. Cardiovascular used to assess volumes, function, LGE extent at 24-month follow-up. LV reverse...
Hybrid imaging provides a non-invasive assessment of coronary anatomy and myocardial perfusion. We sought to evaluate the added clinical value hybrid in multi-centre multi-vendor setting.Fourteen centres enrolled 252 patients with stable angina intermediate (20-90%) pre-test likelihood artery disease (CAD) who underwent perfusion scintigraphy (MPS), CT angiography (CTCA), quantitative (QCA) fractional flow reserve (FFR). MPS/CTCA images were obtained by 3D image fusion. Blinded core-lab...
Purpose To define reference values of cardiac volumes, dimensions, and new morpho‐functional parameters normalized for age, gender, body surface area by cine‐bSSFP (balanced steady‐state free‐precession) magnetic resonance (MR). Materials Methods We enrolled 308 healthy subjects subdivided gender six age classes: class I, >15–20 years; II, >20–30 III, >30–40 IV, >40–50 V, >50–60 VI >60 years. Dimensional, volumetric the left (LV) right (RV) ventricles were measured using...
Experimental data show that the right ventricle (RV) is more resistant to ischemia than left ventricle. To date, limited are available in humans because of difficulty discriminating reversible from irreversible ischemic damage. We sought characterize RV injury patients with reperfused myocardial infarction using cardiovascular magnetic resonance.In 3 tertiary centers, 242 consecutive acute ST-segment elevation were studied resonance at 1 week and 4 months after infarction. T2-weighted...
In nonischaemic dilated cardiomyopathy (NICM), replacement myocardial fibrosis as detected by late gadolinium enhancement (LGE) at cardiovascular magnetic resonance (CMR) is associated with poor prognosis. We investigated the as-yet unexplored prognostic significance of interstitial in NICM, using T1-mapping CMR.Eighty-nine NICM patients (63 men, age 59 ± 14 years) left ventricular systolic dysfunction (ejection fraction 41 13%) underwent comprehensive clinical and CMR evaluation,...
The aim of this registry was to evaluate the additional prognostic value a composite cardiac magnetic resonance (CMR)-based risk score over standard-of-care (SOC) evaluation in large cohort consecutive unselected non-ischaemic cardiomyopathy (NICM) patients.In DERIVATE (www.clinicaltrials.gov/registration: RCT#NCT03352648), 1000 (derivation cohort) and 508 (validation NICM patients with chronic heart failure (HF) left ventricular ejection fraction <50% were included. All-cause mortality...
Background Myocardial hyperintensity on T2-weighted short-tau inversion recovery (STIR) (HyT2) cardiac magnetic resonance (CMR) images has been demonstrated in patients with hypertrophic cardiomyopathy (HCM) and is considered a sign of acute damage. The aim the current study was to evaluate relationship between HyT2 both a) markers ventricular electrical instability b) clinical CMR parameters. Methods Sixty-five underwent thorough examination, consisting 24-h ECG recording examination...
Aims In the EXPLORER‐HCM trial, mavacamten reduced left ventricular outflow tract obstruction (LVOTO) and improved functional capacity of symptomatic hypertrophic obstructive cardiomyopathy (HOCM) patients. We sought to define potential use by comparing real‐world HOCM patients with those enrolled in assessing their eligibility treatment. Methods results collected information on followed up at 25 Italian HCM outpatient clinics significant LVOTO (i.e. gradient ≥30 mmHg rest or ≥50 after...
Cardiac involvement in systemic amyloidosis is caused by the extracellular deposition of misfolded proteins, mainly immunoglobulin light chains (AL) or transthyretin (ATTR), and may be detected cardiovascular magnetic resonance (CMR). The aim this study was to measure myocardial volume (ECV) amyloid patients with a novel T1 mapping CMR technique determine correlation between ECV disease severity.Thirty-six biopsy-proven (mean age 70 ± 9 years, 31 men, 30 AL six ATTR amyloidosis) seven...
No data are available about normal ranges for native T1 in human myocardium using General Electric (GE) scanners.To establish myocardial values and evaluate regional variability the influence of physiological factors.Prospective.One hundred healthy volunteers with electrocardiogram, no cardiovascular/systemic diseases, or risk factors (age range: 20-70 years; 50 females).1.5 T/Steady-state free precession cine a modified Look-Locker inversion recovery sequence diastole (also systole 61...