A5020701224- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Coronary Interventions and Diagnostics
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Parathyroid Disorders and Treatments
- Infective Endocarditis Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Mechanical Circulatory Support Devices
- Cardiac tumors and thrombi
- Cardiomyopathy and Myosin Studies
- Respiratory Support and Mechanisms
- Peripheral Artery Disease Management
- Cardiac pacing and defibrillation studies
- Cardiac Arrest and Resuscitation
- Aortic Disease and Treatment Approaches
- Ion channel regulation and function
- Inflammatory Biomarkers in Disease Prognosis
- Cardiac, Anesthesia and Surgical Outcomes
Marche Polytechnic University
2023-2025
Ospedali Riuniti Marche Nord
2025
University of Campania "Luigi Vanvitelli"
2025
Ospedali Riuniti Umberto I
2024
Ospedale Santa Maria
2024
Centro Cardiologico Monzino
2024
San Salvatore Hospital
2023-2024
University of Macerata
2023-2024
Ospedale di Macerata
2024
Ospedali Riuniti di Ancona
2019-2023
Aims In the EXPLORER‐HCM trial, mavacamten reduced left ventricular outflow tract obstruction (LVOTO) and improved functional capacity of symptomatic hypertrophic obstructive cardiomyopathy (HOCM) patients. We sought to define potential use by comparing real‐world HOCM patients with those enrolled in assessing their eligibility treatment. Methods results collected information on followed up at 25 Italian HCM outpatient clinics significant LVOTO (i.e. gradient ≥30 mmHg rest or ≥50 after...
Summary Mean platelet volume (MPV) has been proposed as a marker of reactivity and cardiovascular risk. Its prognostic significance not thoroughly investigated in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). We included 1,041 consecutive NSTE-ACS. Patients were divided quartiles according to the MPV value on admission (fl) i.e. Q1<7.5; Q2=7.5–8.0; Q3=8.1–8.8; Q4≥8.9. The primary study endpoint was composite death re-myocardial infarction (MI) at one year. Secondary...
Despite troponin assay being a part of the diagnostic work up in many conditions with acute chest pain, little is known about its frequency and clinical implications aortic syndromes (AASs). In our study we assessed frequency, impact on delay, inappropriate treatments, prognosis elevation AAS.Data were collected from prospective metropolitan AAS registry (398 patients diagnosed between 2000 2013). Cardiac test, using either standard or high sensitivity assay, was performed according to...
Abstract A 54–year–old male was diagnosed in 2018 with hypertrophic obstructive cardiomyopathy (HOCM); genetic test negative for Sarcomeric HCM mutations. No relevant comorbidities. Cardiac MRI revealed intramyocardial LGE inferolateral, anterior and septal regions. He receiving nadolol 80 mg once daily (o.d.) due to hemodynamically significant latent LVOT obstruction at transtoracic echocardiography (TTE). risk score 2.9%/5 years. In early 2024, during a follow–up (FU) visit our CMP clinic,...
Abstract A 27–year–old male was diagnosed at the age of 15 with sarcomeric hypertrophic obstructive cardiomyopathy (HOCM) (MYH–7 gene, variant c1816 G›A). No comorbidities. Patient underwent periodic follow–ups showing a predominant mid–ventricular obstruction evolution in apical aneurysm. He on beta–blockers. Due to massive septal hypertrophy (30 mm), extensive late gadolinium enhancement (LGE) MRI evaluation and aneurysm, 22 he S–ICD implantation for primary prevention SD. At most recent...
Abstract Introduction Mavacamten, a first–in–class cardiac myosin ATPase inhibitor used as second–line therapy for hypertrophic obstructive cardiomyopathy (HOCM), became available in Italy early 2024 under compassionate use program. Aim To describe experience of Mavacamten single centre HOCM population. Methods All patients had peak LVOT gradient ≥ 50 mmHg, either at baseline or provoked, LVEF ≥55% and were symptomatic the highest tolerated dose first–line drugs. Genotyping cytochrome P450...
Abstract Introduction Hereditary transthyretin amyloidosis (ATTRv) is a rare, heterogenous, inherited disorder caused by over 130 gene mutations. Its prevalence was estimated to 4.33/million in 2020 Italy. Whether growing disease awareness and improved diagnostics may have increased national diagnoses the last 4 years unresolved. Methods All alive ATTRv from 2004 2024 16 Italian referral centers were retrospectively assessed included analysis. Results As of March 2024, 373 patients active...
The use of high-sensitivity cardiac Troponin T (hs-cTnT) assay might lead to overdiagnosis and overtreatment Acute Coronary Syndromes (ACS). This study assessed the epidemiological, clinical prognostic impact introducing hs-cTnT in everyday practice an Emergency Department. We compared all consecutive patients presenting with suspected ACS at Department, for whom troponin levels were measured. In particular, we considered 597 during March 2010, when standard (cTnT) was used, 629 2011, test...
Cardiac amyloidoses (CAs) are an increasingly recognised group of infiltrative cardiomyopathies associated with high risk adverse cardiac events. We sought to characterise the characteristics and clinical value right ventricular (RV) electroanatomic voltage mapping (EVM) in CA.
<b><i>Objectives:</i></b> To investigate the prognostic significance of baseline white blood cell count (WBCc) in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) and its additive predictive value beyond Global Registry Acute Coronary Events (GRACE) score. <b><i>Methods: </i></b>We included 1,315 consecutive NSTE-ACS patients. Patients were divided quartiles according to WBCc (cells per 1 mm<sup>3</sup>) i.e. Q1...
Background: Although sutureless and rapid deployment aortic valve replacement (SURD-AVR) has been associated with an increased rate of permanent pacemaker (PPM) implantation compared to conventional AVR (c-AVR), the predictors new conduction abnormalities remain be clarified. This study aimed identify risk factors for disorders in patients undergoing surgery. Methods: Data from 243 receiving minimally invasive were prospectively collected. SURD-AVR was performed 103 (42.4%) c-AVR 140...
In accordance with current guidelines, patients discharged after acute myocardial infarction (AMI) are usually prescribed agents acting on the renin–angiotensin system (ACE-I/ARB). However, adherence to prescribing medications is a recognized problem and most studies demonstrating value of were limited by their non-randomized design 'healthy-adherer' bias. Herein we sought evaluate relationship between ACE-I/ARB risk subsequent AMIs, using self-controlled case-series which virtually...
Background and Objectives: Cardiac magnetic resonance (CMR) imaging has become an essential instrument in the study of cardiomyopathies; it recently been integrated into diagnostic workflow for cardiac amyloidosis (CA) with remarkable results. An additional emerging role is stratification arrhythmogenic risk by scar analysis possibility merging these data electro-anatomical maps. This made possible using a software (ADAS 3D, Galgo Medical, Barcelona, Spain) able to provide 3D heart models...
Mitral regurgitation (MR) is a broadly diffuse valvular heart disease (VHD) with significant impact on healthcare system and patient’s prognosis. Transcatheter mitral valve interventions (TMVI) are now well-established techniques included in the therapeutic armamentarium for managing patients regurgitation, either primary or functional MR. Even if guidelines give indications regarding correct management of this VHD, wide heterogeneity clinical background, heart’s anatomy make each patient...
Atrial fibrillation is common in the setting of acute coronary syndromes (ACS) although its impact on ACS remains controversial.To describe in-hospital management patients with atrial and evaluating mid-term outcome.We analysed data two prospective multicentre nationwide registries (IN-ACS Outcome MANTRA) to assess clinical characteristics, management, outcomes fibrillation. Study included death from any cause a composite end-point death/re-infarction/stroke/major bleeding within index...
Objectives To prospectively compare the impact of ultrathin‐strut cobalt‐chromium (Cro‐Co) bare metal stent (BMS) versus thin‐strut stainless steel (SS) BMS on clinically driven target lesion revascularization (TLR). Background Stent characteristics are an important determinant restenosis. Thinner strut Cro‐Co is associated with a reduction neointimal formation compared to SS BMS. The advantages in real‐world population not clear. Methods Patients undergoing percutaneous coronary...
Non-ST segment elevation acute coronary syndrome (NSTE-ACS) is a heterogeneous in terms of patho-physiological mechanisms and prognosis. We sought to investigate the clinical features associated with complicated athero-thrombotic (CAT) lesions their prognostic relevance NSTE-ACS.We enrolled 701 consecutive NSTE-ACS patients without previous bypass undergoing angiography. The study population was divided into two groups according presence/absence angiographic signs endoluminal thrombi and/or...
Intra-aortic balloon counterpulsation (IABP) is the leading technique for cardiovascular support in most critical conditions. The beneficial effects of procedure are widely known, but some drawbacks remain unsolved: high cost and controversial effect presence cardiac arrhythmia, both related to control intra-aortic inflation deflation. This paper describes clinical validation a completely passive solution (PIABP), which substitutes time-controlled pumping system by simple pressure-controlled...