A5012099531- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Fibrosis and Remodeling
- Cardiac Imaging and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Nitric Oxide and Endothelin Effects
- Acute Myocardial Infarction Research
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Thyroid Disorders and Treatments
- Peptidase Inhibition and Analysis
- Cardiac electrophysiology and arrhythmias
- Heat shock proteins research
- Pulmonary Hypertension Research and Treatments
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Cardiovascular Disease and Adiposity
- Viral Infections and Immunology Research
- Receptor Mechanisms and Signaling
- Radiopharmaceutical Chemistry and Applications
- Cardiac pacing and defibrillation studies
- Hormonal Regulation and Hypertension
- Cardiac Ischemia and Reperfusion
- Atrial Fibrillation Management and Outcomes
Istituto di Fisiologia Clinica
2008-2017
Fondazione Toscana Gabriele Monasterio
2008-2016
Scuola Superiore Sant'Anna
2008-2016
Azienda Ospedaliera Universitaria Pisana
2016
Leiden University Medical Center
2016
Vall d'Hebron Hospital Universitari
2016
Turku University Hospital
2016
University of Turku
2016
Imperial College London
2016
University Hospital of Zurich
2016
Background— The choice of imaging techniques in patients with suspected coronary artery disease (CAD) varies between countries, regions, and hospitals. This prospective, multicenter, comparative effectiveness study was designed to assess the relative accuracy commonly used for identifying significant CAD. Methods Results— A total 475 stable chest pain intermediate likelihood CAD underwent computed tomographic angiography stress myocardial perfusion by single photon emission tomography or...
Hybrid imaging provides a non-invasive assessment of coronary anatomy and myocardial perfusion. We sought to evaluate the added clinical value hybrid in multi-centre multi-vendor setting.Fourteen centres enrolled 252 patients with stable angina intermediate (20-90%) pre-test likelihood artery disease (CAD) who underwent perfusion scintigraphy (MPS), CT angiography (CTCA), quantitative (QCA) fractional flow reserve (FFR). MPS/CTCA images were obtained by 3D image fusion. Blinded core-lab...
Abstract Background: Cardiac natriuretic hormones (CNHs) are a family of related peptides, including atrial peptide (ANP), brain (BNP), and other peptides derived from the N-terminal portion proANP proBNP chains. Assays for cardiac have been proposed to help assess clinical conditions associated with expanded fluid volume. In particular, assays can be useful distinguishing healthy subjects patients in different stages heart failure. Measurements these also considered prognostic indicators...
Interest in the antithrombotic potential of diets enriched with fish oil-derived polyunsaturated fatty acids (omega-3 PUFAs) prompted us to examine how these acids, when taken preoperatively, affect hemostasis, plasma lipid levels, and production prostacyclin (PGI2) by vascular tissues atherosclerotic patients undergoing coronary artery bypass graft surgery. Fifteen angiographically proven disease received 3 g/day eicosapentaenoic acid 1.3 docosahexaenoic as capsules purified oil for 28 days...
In order to study the relationships between sex hormones, aging, and circulating levels of cardiac natriuretic peptides define reference values for atrial peptide (ANP) brain (BNP) assays, we measured plasma in a large group healthy adults divided according age sex. We studied 216 subjects both sexes (109 men 107 women) with ranging from 20 77 years (mean 43.2+/-14.8 years). All were non-obese had normal arterial blood pressure; they free acute diseases, including asymptomatic heart disease....
Objective— Circulating levels of high-sensitivity cardiac troponin T (hs-cTnT) and N terminal pro brain natriuretic peptide (NT-proBNP) are predictors prognosis in patients with coronary artery disease (CAD). We aimed at evaluating the effect atherosclerosis myocardial ischemia on release hs-cTnT NT-proBNP suspected CAD. Approach Results— Hs-cTnT were measured 378 (60.1±0.5 years, 229 males) stable angina unknown CAD enrolled Evaluation Integrated Cardiac Imaging (EVINCI) study. All...
Obesity is a complex pathology with interacting and confounding causes due to the environment, hormonal signaling patterns, genetic predisposition. At present, Zucker rat an eligible model for research on obesity metabolic syndrome, allowing scrutiny of gene expression profiles. Real-time PCR benchmark method measuring mRNA expressions, but accuracy reproducibility its data greatly depend appropriate normalization strategies. In model, no specific reference genes have been identified in...
It has been suggested that the induction of lipocortin-1, a phospholipase A2-inhibitory protein, may mediate anti-inflammatory action glucocorticoids. We assessed production prostaglandin E2, thromboxane B2, and leukotriene B4 expression lipocortin-1 in different populations blood leukocytes alveolar macrophages (obtained by bronchoalveolar lavage) from patients with inflammatory lung diseases (bronchial asthma, n = 21; interstitial disease, 6) undergoing glucocorticoid treatment at...
Summary This study explores the effects on some hematological parameters of a low-dose aspirin regimen (50 mg/day) versus conventional treatment with reported antithrombotic efficacy (324 mg/day), in patients acute myocardial infarction. Fifteen were randomized into 3 equal groups receiving 50 mg or 324 placebo, daily for 21 days. Compared bleeding time was significantly and similarly prolonged both doses (+ 71 ± 22% + 69 20%, mean S.D.). Aspirin mg/day suppressed arachidonate-induced...