A5066707442- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Ion channel regulation and function
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Growth Hormone and Insulin-like Growth Factors
- Congenital Heart Disease Studies
- Vitamin K Research Studies
- Hormonal Regulation and Hypertension
- Cardiac Imaging and Diagnostics
- Vitamin D Research Studies
- Parathyroid Disorders and Treatments
- Cardiac Valve Diseases and Treatments
- Mitochondrial Function and Pathology
- Pituitary Gland Disorders and Treatments
- Cardiac electrophysiology and arrhythmias
- Vitamin C and Antioxidants Research
- Head and Neck Anomalies
- Adipose Tissue and Metabolism
- Cardiac Ischemia and Reperfusion
- Pharmacological Effects and Toxicity Studies
- Renal function and acid-base balance
- Cardiac Arrhythmias and Treatments
- Cardiac Fibrosis and Remodeling
- Cardiovascular Effects of Exercise
Istituto di Fisiologia Clinica
2015-2024
National Research Council
2015-2024
Consorzio Pisa Ricerche
2019-2022
University of Padua
2016-2021
Fondazione Toscana Gabriele Monasterio
2008-2018
Regione Toscana
2010-2017
Czech Academy of Sciences, Institute of Physiology
1996-2016
King's College London
2016
Hospital General Universitario Gregorio Marañón
2016
Tampere University
2016
Context-Data regarding the association between subclinical hypothyroidism and cardiovascular disease outcomes are conflicting among large prospective cohort studies.This might reflect differences in participants' age, sex, thyroid-stimulating hormone (TSH) levels, or preexisting disease.Objective-To assess risks of coronary heart (CHD) total mortality for adults with hypothyroidism. Data Sources StudySelection-The databases MEDLINE EMBASE (1950 to May 31, 2010) were searched without language...
Background— Clinical and experimental data have suggested a potential negative impact of low-T3 state on the prognosis cardiac diseases. The aim present prospective study was to assess role thyroid hormones in patient population with heart disease. Methods Results— A total 573 consecutive patients underwent function profile evaluation. They were divided two subgroups: group I, 173 low T3, ie, free T3 (fT3) <3.1 pmol/L, II, 400 normal fT3 (≥3.1 pmol/L). We considered cumulative death...
The effects of subclinical thyroid dysfunction on cardiac outcome are not well defined.To assess the relationship between mild and incidence death in patients, we evaluated 3121 patients. Cardiac overall deaths were considered. Four groups defined: euthyroidism, hypothyroidism (SCH), hyperthyroidism (SCT), low triiodothyronine syndrome (low T3).After mean follow-up 32 months, there 65 140 (3.4% 7.3%), respectively, 15 27 (7.2% 13.0%) SCH, 8 9 (8.2% 9.2%) SCT, 59 119 (6.5% 13.1%) T3. Survival...
Context: Low-T3 syndrome is a predictor of poor outcome in patients with cardiac dysfunction. The study aimed to assess the short-term effects synthetic l-T3 replacement therapy low-T3 and ischemic or nonischemic dilated cardiomyopathy (DC).
Multicompartmental analysis of thyroxine (T4) and 3,5,3'-triiodothyronine (T3) kinetics based on the plasma disappearance curves two tracer hormones (J. J. DiStefano III, M. Jang, T. K. Malone, Broutman. Endocrinology 110: 198-213, 1982 Jang. 111: 108-117, 1982) was extended to include additional experimental data, namely, appearance curve in labeled T3 generated vivo from precursor T4. Kinetic data obtained 14 studies carried out normal subjects by using a composite six-pool model made it...
Abstract Mitochondrial dysfunctions critically affect cardiomyocyte survival during ischemia/reperfusion (I/R) injury. In this scenario p53 activates multiple signaling pathways that impair cardiac mitochondria and promote cell death. is a validated target of miR-30 whose levels fall under ischemic conditions. Although triiodothyronine (T3) rescues post-ischemic mitochondrial activity viability, no data are available on its role in the modulation I/R. Here we test hypothesis early T3...
Arterial hypertension is known to be frequently associated with thyroid dysfunction, a particularly high prevalence in chronic hypothyroidism. However, our knowledge no comprehensive study addressed causal mechanisms possibly involved this association. We here report the physiological relationships between blood pressure and neuro-humoral modifications induced by acute hypothyroidism normotensive subjects. Twelve patients previous total thyroidectomy were studied. Ambulatory 24-h monitoring...