A5038978714- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Cardiovascular Issues in Pregnancy
- Cardiac pacing and defibrillation studies
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cardiac Imaging and Diagnostics
- Coronary Artery Anomalies
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Effects of Exercise
- Cardiovascular and Diving-Related Complications
- Heart Failure Treatment and Management
- Cardiac tumors and thrombi
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Congenital heart defects research
- Renal and Vascular Pathologies
- Cardiomyopathy and Myosin Studies
- Acute Ischemic Stroke Management
Amsterdam University Medical Centers
2018-2025
Amsterdam UMC Location University of Amsterdam
2016-2025
University of Amsterdam
2016-2025
Amsterdam Neuroscience
2018-2024
Netherlands Heart Institute
2009-2024
Leiden University Medical Center
2007-2024
Amsterdam University of Applied Sciences
2024
Amsterdam University of the Arts
2020-2021
University Medical Center
2008-2021
OLVG
2020
The ESC Guidelines represent the views of and were produced after careful consideration scientific medical knowledge, evidence available at time their publication.The is not responsible in event any contradiction, discrepancy, and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies.Health professionals are encouraged take fully into account when exercising clinical...
Background— To facilitate the optimal timing of pulmonary valve replacement, we analyzed preoperative thresholds right ventricular (RV) volumes above which no decrease or normalization RV size takes place after surgery. Methods and Results— Between 1993 2006, 71 adult patients with corrected tetralogy Fallot underwent replacement in a nationwide, prospective follow-up study. Patients were evaluated cardiovascular magnetic resonance both preoperatively postoperatively. Changes expressed as...
Sudden cardiac death (SCD) is a major cause of mortality in adults with congenital heart disease (CHD). The aim this study was to determine the adult CHD population at risk SCD and clinical parameters associated SCD.We performed multicenter case-control study. Patients who died suddenly as result proven or presumed arrhythmia were included (cases). For each case, 2 controls matched on diagnosis, type surgical intervention, age, gender included. From 3 databases including 25 790 CHD, 1189...
<h3>OBJECTIVE</h3> To evaluate the application of guidelines in decision making process leading to medical or surgical treatment for aortic stenosis elderly patients. <h3>DESIGN</h3> Cohort analysis based on a prospective inclusive registry. <h3>SETTING</h3> 205 consecutive patients (⩾ 70 years) with clinically relevant isolated and without serious comorbidity, seen first time Doppler-echocardiographic laboratories three university hospitals Netherlands. <h3>RESULTS</h3> The initial choice...
Background— The role of angiotensin II receptor blockers in patients with a systemic right ventricle has not been elucidated. Methods and Results— We conducted multicenter, double-blind, parallel, randomized controlled trial blocker valsartan 160 mg twice daily compared placebo caused by congenitally or surgically corrected transposition the great arteries. primary end point was change ventricular ejection fraction during 3-year follow-up, determined cardiovascular magnetic resonance imaging...
BackgroundTwo different enzyme preparations, agalsidase alfa (ReplagalTM, Shire) and beta (FabrazymeTM, Genzyme), are registered for treatment of Fabry disease. We compared the efficacy tolerability towards two preparations administered at identical protein dose in a randomized controlled open label trial.Methodology/Principal FindingsThirty-four disease patients were treated with either or equal 0.2 mg/kg biweekly. Primary endpoint was reduction left ventricular mass after 12 24 months...
The method used to delineate the boundary of right ventricle (RV), relative trabeculations and papillary muscles in cardiovascular magnetic resonance (CMR) ventricular volume analysis, may matter more when these structures are hypertrophied than individuals with normal anatomy. This study aimed compare two methods cavity delineation patients systemic RV.
The right ventricle (RV) remodels early after pulmonary valve replacement (PVR) in tetralogy of Fallot (TOF) patients. Previously reported preoperative thresholds to achieve postoperative RV normalization were consistently close 80 mL/m 2 for end-systolic volume (ESV) and 160 end-diastolic (EDV). Our objective was determine whether these also associated with mid-to-late clinical events. Out a multicentre cohort 157 TOF patients who had undergone PVR, 65 (62% male, age 29 ± 8 years, homograft...
Adult congenital heart disease (ACHD) predisposes to infective endocarditis (IE). Surgical advancements have changed the ACHD population, whereas associated prosthetic material may constitute additional IE targets. We aimed prospectively determine contemporary incidence, risk factors, and predictors of in a nationwide cohort, focusing on presence prosthetics.We identified 14 224 patients followed CONCOR registry (50.5% female, median age 33.6years). incidence was determined using Poisson...
Pharmacological options for patients with a failing systemic right ventricle (RV) in the context of transposition great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are not well defined. This study aims to investigate feasibility and effects sacubitril/valsartan treatment single-centre cohort patients.Data on all consecutive adult (n=20, mean age 46 years, 50% women) RV biventricular circulation treated our centre reported. Patients ejection fraction ≤35% who were...
Gender differences in prognosis have frequently been reported cardiovascular disease but less so congenital heart disease. We investigated whether gender is associated with outcome adult patients disease.From the CONgenital CORvitia (CONCOR) national registry for adults disease, 7414 were identified. All outcomes before entry into and during subsequent follow-up recorded, between men women analyzed underlying defect taken account. Median age at end of was 35 years (range, 17 to 91 years);...
To assess whether exercise training in adult patients with a systemic right ventricle (RV) improves capacity and quality of life lowers serum N-terminal prohormone brain natriuretic peptide (NT-proBNP) levels. Multi-centre parallel randomized controlled trial. Patients RV due to congenitally or surgically corrected transposition the great arteries. Fifty-four RV, were using unmarked opaque envelopes an intervention group (n = 28) three sessions per week for 10 consecutive weeks, control 26)....
<h3>Background</h3> Although QRS duration >180 ms has prognostic value in adults with tetralogy of Fallot (TOF), its sensitivity to predict mortality is low. Fragmented complexes, a simple measurement on ECG, are related myocardial fibrosis and dysfunction patients TOF. Our objective was determine whether fragmentation predicts major outcomes <h3>Methods</h3> This multicentre study included adult TOF from prospective registry. Notches the complex ≥2 contiguous leads 12-lead not bundle...