A5055340351- Congenital Heart Disease Studies
- Fetal and Pediatric Neurological Disorders
- Renal and Vascular Pathologies
- Pregnancy and preeclampsia studies
- Cardiac Imaging and Diagnostics
- Coronary Artery Anomalies
- Aortic Disease and Treatment Approaches
- Congenital Diaphragmatic Hernia Studies
- Neonatal and fetal brain pathology
- Cardiovascular Issues in Pregnancy
- Pluripotent Stem Cells Research
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Tracheal and airway disorders
- Pulmonary Hypertension Research and Treatments
- Alzheimer's disease research and treatments
- Mechanical Circulatory Support Devices
- Reproductive Biology and Fertility
- Cardiac Structural Anomalies and Repair
- Reproductive System and Pregnancy
- COVID-19 Clinical Research Studies
- Autopsy Techniques and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare cost, quality, practices
- Cardiovascular Function and Risk Factors
University of Iowa Stead Family Children’s Hospital
2020-2025
University of Iowa Hospitals and Clinics
2021-2023
University of Iowa
2020-2022
Driscoll Children's Hospital
2018-2021
University of Toronto
2014-2019
Hospital for Sick Children
2012-2019
SickKids Foundation
2014-2019
International Peace Maternity & Child Health Hospital
2015
Shanghai Jiao Tong University
2015
Mount Sinai Hospital
2015
Background— Fetal hypoxia has been implicated in the abnormal brain development seen newborns with congenital heart disease (CHD). New magnetic resonance imaging technology now offers potential to investigate relationship between fetal hemodynamics and dysmaturation. Methods Results— We measured size, oxygen saturation, blood flow major vessels of circulation 30 late-gestation fetuses CHD normal controls using phase-contrast T2 mapping. hemodynamic parameters were calculated from a...
Background: Brain injury, impaired brain growth, and long-term neurodevelopmental problems are common in children with transposition of the great arteries. We sought to identify clinical risk factors for injury poor growth infants arteries undergoing arterial switch operation, examine their relationship outcome. Methods: The brains 45 surgical repair were imaged pre- postoperatively using magnetic resonance imaging. weight z scores calculated based on volume autopsy reference data....
Objective Human myocardium has a complex and anisotropic 3D fiber pattern. It remains unknown, however, when in fetal life this pattern develops whether the human heart is structurally fully mature at birth. We aimed here to use diffusion tensor MRI (DTI) tractography characterize evolution of architecture developing heart. Methods hearts (n = 5) between 10–19 weeks gestation were studied. The from 6-day old neonate an adult served as controls. degree myocardial anisotropy was measured by...
The amyloid-beta precursor protein (AbetaPP) is a ubiquitously expressed transmembrane whose cleavage product, the (Abeta) protein, deposited in amyloid plaques neurodegenerative conditions such as Alzheimer disease, Down syndrome, and head injury. We recently reported that this normally associated with conditions, by human embryonic stem cells (hESCs). now report differential processing of AbetaPP via secretase enzymes regulates proliferation differentiation hESCs. hESCs endogenously...
Objective We investigated the physiologic impact of acute maternal hyperoxygenation (MH) in human fetuses with and without congenital heart disease (CHD) using fetal cardiac magnetic resonance (CMR) order to explore potential therapeutic benefits chronic MH. Methods examined 17 normal 20 late gestation CHD on a 1.5 T CMR system. Flows were measured major vessels phase contrast MRI. The T2 umbilical venous blood was mapping. measurements repeated during results compared Student's t-test,...
To investigate the relationship between foetal haemodynamics and postnatal clinical presentation in patients with transposition of great arteries using phase-contrast cardiovascular magnetic resonance.A severe irreversible form persistent pulmonary hypertension newborn occurs up to 5% remains an important cause morbidity mortality these infants. Restriction at foramen ovale ductus arteriosus has been identified as a risk factor for development hypertension, this can now be studied resonance...
To evaluate whether structural and microstructural brain abnormalities in neonates with congenital heart disease (CHD) correlate neuronal network dysfunction measured by analysis of EEG connectivity.We studied a prospective cohort 20 CHD who underwent continuous monitoring before surgery to assess functional maturation connectivity, magnetic resonance imaging (MRI) determine the presence injury development, diffusion tensor MRI development.Neonates delayed development demonstrated...
Abstract Introduction The physiological signals that direct the division and differentiation of zygote to form a blastocyst, subsequent embryonic stem cell during early embryogenesis, are unknown. Although number growth factors, including pregnancy-associated hormone human chorionic gonadotropin (hCG) secreted by trophoblasts lie adjacent embryoblast in it is not known whether these factors directly signal cells (hESCs). Methods Here we used hESCs as model inner mass examine hormonal...
ABSTRACT Background Congenital heart disease (CHD) patients with pulmonary valve failure may undergo transcatheter replacement (TPVR). Aspirin is often prescribed as long‐term therapy after TPVR to prevent thromboembolic events (TE). Aims We aimed examine the prevalence of aspirin resistance within CHD population. Methods The VerifyNow point‐of‐care test quantifies platelet aggregation Reactivity Units (ARU). ARU values greater than 550 suggest (AR). A retrospective chart review analyzed...
The growth factors that drive the division and differentiation of stem cells during early human embryogenesis are unknown. secretion endorphins, progesterone (P(4)), chorionic gonadotropin, 17beta-estradiol, gonadotropin-releasing hormone by trophoblasts lie adjacent to embryoblast in blastocyst suggests these pregnancy-associated may directly signal development embryoblast. To test this hypothesis, we treated embryoblast-derived embryonic (hESCs) with ICI 174,864, a delta-opioid receptor...
To investigate the regional flow distribution in patients with Fontan circulation by using magnetic resonance imaging (MRI).We identified 39 children (18 females and 21 males; mean age, 9.3 years; age range, 3.3-17.0 years) whom volumes across thoracic abdominal arteries veins were measured MRI. The divided into three groups: fenestrated group MRI performed under general anesthesia (GA) (Group 1, 15 patients; average 5.9 years), completed GA 2, 6 8.7 without 3, 18 12.5 years). patient data...
Geleophysic dysplasia (GD) is a rare genetic disorder characterized by acromelic dysplasia. type 1 (MIM 231050) autosomal recessive and caused homozygous or compound heterozygous mutation in the ADAMTSL2 (a disintegrin metalloproteinase with thrombosponding repeats-like 2) gene. 2 614185) dominant fibrillin ( FBN1) Here, we present clinical histopathologic findings child GD newly identified mutations. The 1st was probably pathogenic one, c.[1934G>A] p.[Arg645His], located exon 13; 2nd,...
Despite the importance of autopsy for quality improvement, rates have declined dramatically in recent decades due to poor acceptance by families and physicians high costs institutions.To compare postmortem imaging (PMI) with patients congenital heart defects see if PMI could substitute some or all cases two methods.Ten disease dying hospital during study period whom an was planned underwent using magnetic resonance (PMMRI) (6 patients) computed tomographic angiography (PMCTA) (10 permission...
Abstract Division of the human zygote leads to formation blastocyst that contains embryonic stem cells (hESC) which develop into embryo. Little is known about physiological signals direct hESC division and differentiation during early embryogenesis. A number growth factors, including pregnancy-associated hormone chorionic gonadotropin (hCG), are secreted by trophoblasts^1-3^ lie adjacent embryoblast in blastocyst, but it not whether these factors directly signal epiblast. Here we show hCG...
Background Maternal hyperoxygenation (MH) has been used for intrauterine growth restriction and proposed as a way to improve ventricular in the setting of congenital heart disease (CHD)[1,2]. Fetal lamb experiments reveal increases SaO2 umbilical venous (UV) blood reduction pulmonary vascular resistance during MH [3]. Doppler suggests that human fetal flow (PBF) [4]. The combination phase contrast (PC) MRI MR oximetry using T2 mapping offers potential comprehensive hemodynamic assessment...
There has been a paradigm shift in the management of patients with congenital heart disease move away from conventional surgical treatment favor percutaneous catheter-based approach across spectrum valvular diseases. The Sapien S3 valve implantation pulmonary position previously reported using transcatheter insufficiency due to an enlarged right ventricular outflow tract. In this report, we present 2 unique cases intraoperative hybrid valves complex pulmonic and tricuspid disease.
Altered coagulation is a striking feature of COVID-19. Adult patients with congenital heart disease (ACHD) are prone to thromboembolic (TE) and bleeding complications. The purpose this study was investigate the prevalence risk factors for COVID-19 TE/bleeding complications in ACHD patients. COVID-19-positive were included between May 2020 November 2021. TE events ischemic cerebrovascular accident, systemic pulmonary embolism, deep venous thrombosis, myocardial infarction, intracardiac...
To investigate the use of MRI to assess placental function in terms placental-fetal oxygen (O2) transport utero. Eight women with normal pregnancies were scanned using a 1.5 T Siemens system. measure O2 transport, blood flow (Q) and content (C) measured vessels supplying (uterine arteries fetal descending aorta) draining (uterine, ovarian umbilical veins) placenta. Phase contrast was used Q. Vascular T1 T2 relaxometry saturation hematocrit derive C. The delivery (Do2) return (Ro2) calculated...