A5076207462- Congenital Heart Disease Studies
- Kawasaki Disease and Coronary Complications
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Transplantation: Methods and Outcomes
- Coronary Artery Anomalies
- Cardiovascular Issues in Pregnancy
- Mechanical Circulatory Support Devices
- Cardiovascular Function and Risk Factors
- Obesity, Physical Activity, Diet
- Aortic Disease and Treatment Approaches
- Heart Failure Treatment and Management
- Renal Transplantation Outcomes and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac Arrest and Resuscitation
- Pulmonary Hypertension Research and Treatments
- Cardiac and Coronary Surgery Techniques
- Cardiac Ischemia and Reperfusion
- Viral Infections and Immunology Research
- Organ Transplantation Techniques and Outcomes
- Cardiomyopathy and Myosin Studies
- Health and Lifestyle Studies
- Cardiovascular Effects of Exercise
- Cardiovascular Disease and Adiposity
- Cardiac, Anesthesia and Surgical Outcomes
Johns Hopkins University
2020-2025
Hospital for Sick Children
2015-2024
University of Toronto
2015-2024
Toronto General Hospital
2013-2024
SickKids Foundation
2015-2024
Johns Hopkins Medicine
2020-2024
Ted Rogers Centre for Heart Research
2017-2024
University Health Network
2014-2024
Johns Hopkins Hospital
2021-2024
Montreal Heart Institute
2023
Background— Fetal hypoxia has been implicated in the abnormal brain development seen newborns with congenital heart disease (CHD). New magnetic resonance imaging technology now offers potential to investigate relationship between fetal hemodynamics and dysmaturation. Methods Results— We measured size, oxygen saturation, blood flow major vessels of circulation 30 late-gestation fetuses CHD normal controls using phase-contrast T2 mapping. hemodynamic parameters were calculated from a...
Background— The pathological spectrum of degenerative diseases the mitral valve (MV) that causes regurgitation (MR) is broad, and there limited information on late outcomes MV repair in various subgroups patients pathologies. This study examines this issue. Methods Results— All 840 who had for MR due to from 1985 2004 were prospectively followed with clinical echocardiographic evaluations at biennial intervals up 26 years, median 10.4 years. Clinical, hemodynamic, variables evaluated their...
Hypertrophic cardiomyopathy is the leading cause of sudden cardiac death (SCD) in children and young adults. Our objective was to develop validate a SCD risk prediction model pediatric hypertrophic guide prevention strategies. In an international multicenter observational cohort study, phenotype-positive patients with isolated <18 years age at diagnosis were eligible. The primary outcome variable time from composite events 5-year follow-up: SCD, resuscitated arrest, aborted that is,...
Background: Adult survivors with tetralogy of Fallot constitute a growing population congenital heart disease. We investigated an inception cohort who underwent surgical repair. aimed to characterize late hazard or risk for death, and determine the time-related re-operation pulmonary valve replacement (PVR). Methods: All children (n = 1181) born before 1984 repair at our institution were included. Follow-up (median 20 years after repair) was obtained from 2003 2006 via chart review, clinic...
Background— Fetal tachyarrhythmia may result in low cardiac output and death. Consequently, antiarrhythmic treatment is offered most affected pregnancies. We compared 3 drugs commonly used to control supraventricular tachycardia (SVT) atrial flutter (AF). Methods Results— reviewed 159 consecutive referrals with fetal SVT (n=114) AF (n=45). Of these, 75 fetuses 36 were treated nonrandomly transplacental flecainide (n=35), sotalol (n=52), or digoxin (n=24) as a first-line agent. Prenatal...
Remote ischemic preconditioning (RIPC) induced by transient limb ischemia releases a dialysable circulating protective factor that reduces ischemia-reperfusion injury. Exercise performance in highly trained athletes is limited tissue hypoxemia and acidosis, which may therefore represent type of stress modifiable RIPC.National-level swimmers, 13-27 yr, were randomized to RIPC (four cycles 5-min arm ischemia/5-min reperfusion) or low-pressure control procedure, with crossover. In study 1,...
Thrombosis, usually considered a serious but rare complication of pediatric cardiac surgery, has not been major clinical and/or research focus in the past.We noted 444 thrombi (66% occlusive, 60% symptomatic) 171 1542 surgeries (11%). Factors associated with increased odds thrombosis were age <31 days (odds ratio [OR], 2.0; P=0.002), baseline oxygen saturation <85% (OR, P=0.001), previous 2.6; heart transplantation 4.1; P<0.001), use deep hypothermic circulatory arrest 1.9 P=0.01), longer...
Late graft rejection impairs the long-term function of organ transplants in children. Previous studies suggest patients with wide variation tacrolimus levels may have higher rates late kidney and liver rejection. The reproducibility this finding impact on recipient survival not been reported. We investigated factors associated > 6 months post-transplant 144 heart, kidney, liver, lung transplant recipients (ages 8-18, ≥ 1-yr survivors, receiving tacrolimus-based immunosuppression), comparing...
Background: The ideal aortic valve substitute in young and middle-aged adults remains unknown. We sought to compare the long-term outcomes of patients undergoing Ross procedure those receiving a mechanical replacement (AVR). Methods: From 1990 2014, 258 underwent 1444 had AVR at single institution. Patients were matched into 208 pairs through use propensity score. Mean age was 37.2±10.2 years, 63% male. follow-up 14.2±6.5 years. Results: Overall survival equivalent (Ross versus AVR: hazard...
<h3>Background:</h3> Evidence suggests that inadequate or disturbed sleep is associated with increased cardiovascular risk in adults. There are limited data on quality and children. <h3>Methods:</h3> We obtained adolescents from the 2009/10 cycle of Healthy Heart Schools' Program, a population-based cross-sectional study Niagara region Ontario. Participants underwent measurements cardiometabolic factors, including body mass index (BMI), lipid profile blood pressure, they completed...
Background The healthcare burden related to congenital heart disease ( CHD ) is increasing with improving survival. We assessed changing trends in prenatal risk factors for the current era a Canadian cohort. Methods and Results patients <18 years old (n=2339) controls without structural (n=199) were prospectively enrolled an Ontario province‐wide biobank registry from 2008–2011. Family history, frequency of extra‐cardiac anomalies ECA s), antenatal assessed. Temporal analyzed associations...