A5028265749- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Transplantation: Methods and Outcomes
- Cardiomyopathy and Myosin Studies
- Cardiac Arrest and Resuscitation
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiovascular Effects of Exercise
- Renal Transplantation Outcomes and Treatments
- Viral Infections and Immunology Research
- Coronary Artery Anomalies
- Cardiac Arrhythmias and Treatments
- Adolescent and Pediatric Healthcare
- Cardiovascular Issues in Pregnancy
- Congenital heart defects research
- Cardiac Valve Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- Tracheal and airway disorders
- Metabolism and Genetic Disorders
- Electrolyte and hormonal disorders
- Kawasaki Disease and Coronary Complications
- Pulmonary Hypertension Research and Treatments
- Acute Myocardial Infarction Research
Hospital for Sick Children
2016-2025
University of Toronto
2010-2024
SickKids Foundation
2019-2024
Toronto Public Health
2019-2021
Baylor College of Medicine
2012-2018
Texas Children's Hospital
2012-2018
Pediatrics and Genetics
2016
Boston Children's Hospital
2015
University of British Columbia
2007-2010
British Columbia Children's Hospital
2007-2010
Hypertrophic cardiomyopathy is the leading cause of sudden cardiac death (SCD) in children and young adults. Our objective was to develop validate a SCD risk prediction model pediatric hypertrophic guide prevention strategies. In an international multicenter observational cohort study, phenotype-positive patients with isolated <18 years age at diagnosis were eligible. The primary outcome variable time from composite events 5-year follow-up: SCD, resuscitated arrest, aborted that is,...
Extracorporeal membrane oxygenation (ECMO) has long been the sole means of mechanical support for pediatric patients with end-stage cardiac failure, but a high waitlist mortality and reported survival to hospital discharge less than 50%. The purpose this study was compare ECMO versus ventricular assist device (VAD) support. A review conducted all listed heart transplantation (HTx) since 2002 requiring VAD available from 2004 (Berlin Heart Excor Pediatrics). Competing risks analysis used...
Genetic defects in the RAS/mitogen-activated protein kinase pathway are an important cause of hypertrophic cardiomyopathy (RAS-HCM). Unlike primary HCM (P-HCM), risk sudden cardiac death (SCD) and long-term survival RAS-HCM poorly understood.The study's objective was to compare transplant-free survival, incidence SCD, implantable cardioverter-defibrillator (ICD) use between P-HCM patients.In international, 21-center cohort study, we analyzed phenotype-positive pediatric (n = 188) 567)...
1. Hari Tunuguntla, MD, MPH* 2. Aamir Jeewa, MD† 3. Susan W. Denfield, MD* 1. *Department of Pediatrics, Division Pediatric Cardiology, Texas Children’s Hospital, Baylor College Medicine, Houston, TX 2. †Department Hospital for Sick Children, Toronto, Ontario, Canada * Abbreviations: CMR: : cardiovascular magnetic resonance imaging DCM: dilated cardiomyopathy ECG: electrocardiogram EMB: endomyocardial biopsy IVIg: intravenous immunoglobulin MCS: mechanical circulatory support ...
Hypertrophic cardiomyopathy (HCM) can be associated with an abnormal exercise response. In adults HCM, results on stress testing are predictive of heart failure outcomes. Our goal was to determine whether response is adverse outcomes in pediatric patients HCM. international cohort study including 20 centers, phenotype-positive primary HCM who were <18 years age at diagnosis included. Abnormal defined as a blunted blood pressure and new or worsened ST- T-wave segment changes complex...
Hypertrophic cardiomyopathy is a burdensome condition that inflicts both physical and psychological impairment on those with the disease, negatively impacting health-related quality of life (HRQoL). Given abundance evidence suggesting role activity (PA) in modulating HRQoL healthy populations children, we sought to determine relationship between PA children diagnosed hypertrophic cardiomyopathy.
Congenital heart defects involving left-sided lesions (LSLs) are relatively common birth with substantial morbidity and mortality. Previous studies have suggested a high heritability complex genetic architecture, such that only few LSL loci been identified. We performed genome-wide case–control association study to address the role of variants using discovery cohort 778 cases 2756 controls. identified significant mapping 200 kb region on chromosome 20q11 [P= 1.72 × 10−8 for rs3746446;...