A5027841099- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Aortic Disease and Treatment Approaches
- Cardiomyopathy and Myosin Studies
- Cardiovascular Issues in Pregnancy
- Coronary Artery Anomalies
- Cardiac pacing and defibrillation studies
- Acute Myocardial Infarction Research
- Cardiac Arrest and Resuscitation
- Cardiac Arrhythmias and Treatments
- Heart Failure Treatment and Management
- Transplantation: Methods and Outcomes
- Cardiovascular Effects of Exercise
- Connective tissue disorders research
- Vascular anomalies and interventions
- Neuroscience of respiration and sleep
- Infective Endocarditis Diagnosis and Management
- Family and Patient Care in Intensive Care Units
- Cardiac, Anesthesia and Surgical Outcomes
- Neonatal Respiratory Health Research
- Adolescent and Pediatric Healthcare
Boston Children's Hospital
2016-2025
Harvard University
2016-2025
Boston Children's Museum
2011-2024
Somerville Hospital
2024
Boston University
2023
Children's Hospital
2007-2023
Boston Children's at Waltham
2020-2023
Battelle
2023
Lynn University
2009-2023
Pediatrics and Genetics
2022
The leading cause of death in patients hospitalized for acute myocardial infarction is cardiogenic shock. We conducted a randomized trial to evaluate early revascularization with
In some randomized trials comparing revascularization strategies for patients with diabetes, coronary-artery bypass grafting (CABG) has had a better outcome than percutaneous coronary intervention (PCI). We sought to discover whether aggressive medical therapy and the use of drug-eluting stents could alter approach diabetes multivessel artery disease.In this trial, we assigned disease undergo either PCI or CABG. The were followed minimum 2 years (median among survivors, 3.8 years). All...
ContextDilated cardiomyopathy (DCM) is the most common form of and cause cardiac transplantation in children. However, epidemiology clinical course DCM children are not well established.ObjectiveTo provide a detailed description incidence, causes, outcomes, related risk factors for children.Design SettingLongitudinal study based on population-based, prospective cohort diagnosed as having since January 1, 1996, at 89 pediatric centers retrospectively collected patients seen primarily large...
The Norwood procedure with a modified Blalock-Taussig (MBT) shunt, the first palliative stage for single-ventricle lesions systemic outflow obstruction, is associated high mortality. right ventricle-pulmonary artery (RVPA) shunt may improve coronary flow but requires ventriculotomy. We compared two shunts in infants hypoplastic heart syndrome or related anomalies.Infants undergoing were randomly assigned to MBT (275 infants) RVPA (274 at 15 North American centers. primary outcome was death...
Population-based data on the incidence of pediatric cardiomyopathy are rare because lack large, prospective studies.Since 1996 Pediatric Cardiomyopathy Registry sponsored by National Heart, Lung, and Blood Institute has collected all children with newly diagnosed in New England Central Southwest region (Texas, Oklahoma, Arkansas) United States. We report these regions who received this diagnosis between 1999.We identified 467 cases cardiomyopathy, for an overall annual 1.13 per 100,000 (95...
Cardiogenic shock remains the major cause of death for patients hospitalized with acute myocardial infarction (MI). Although survival in cardiogenic complicating MI has been shown to be significantly higher at 1 year those receiving early revascularization vs initial medical stabilization, data demonstrating long-term are lacking.To determine if affects MI.The Should We Emergently Revascularize Occluded Coronaries Shock (SHOCK) trial, an international randomized clinical trial enrolling 302...
The ability to identify infants with sickle cell anemia who are likely have severe complications later in life would permit accurate prognostication and tailoring of therapy match disease-related risks facilitate planning clinical trials. We attempted define the features such babies by following course 392 children disease from infancy about age 10 years.
Aortic-root dissection is the leading cause of death in Marfan's syndrome. Studies suggest that with regard to slowing aortic-root enlargement, losartan may be more effective than beta-blockers, current standard therapy most centers.
Background— Current information on the epidemiology and outcomes of hypertrophic cardiomyopathy (HCM) in children is limited by disease diversity small case series. Methods Results— The Pediatric Cardiomyopathy Registry has collected prospective retrospective data diagnosed with HCM since 1990. We identified various causes childhood determined relationship between outcomes, cause, age at presentation. Of 855 patients <18 years HCM, 8.7% (n=74) had inborn errors metabolism, 9.0% (n=77)...
Treatment of acute Kawasaki disease with intravenous immune globulin and aspirin reduces the risk coronary-artery abnormalities systemic inflammation, but despite therapy, develop in some children. Studies have suggested that primary corticosteroid therapy might be beneficial adverse events are infrequent short-term use.We conducted a multicenter, randomized, double-blind, placebo-controlled trial to determine whether addition methylprednisolone conventional for abnormalities. Patients 10 or...
Background Cardiogenic shock remains the leading cause of death patients hospitalized with acute myocardial infarction (MI). This study was conducted to examine (1) current spectrum cardiogenic shock, (2) proportion who are potential candidates for a trial early revascularization, and (3) apparent impact revascularization on mortality. Methods Results Nineteen participating centers in United States Belgium prospectively registered all diagnosed shock. Two hundred fifty-one were registered....
Osteonecrosis of the femoral head is an important complication sickle cell disease. We studied 2590 patients who were over 5 years age at entry and followed them for average 5.6 years. Patients examined twice a year, radiographs hips taken least twice: study approximately three later.
Background— Survivors of the Norwood procedure may experience neurodevelopmental impairment. Clinical trials to improve outcomes have focused primarily on methods vital organ support during cardiopulmonary bypass. Methods and Results— In Single Ventricle Reconstruction trial with modified Blalock-Taussig shunt versus right-ventricle-to-pulmonary-artery shunt, 14-month outcome was assessed by use Psychomotor Development Index (PDI) Mental (MDI) Bayley Scales Infant Development-II. We used...
Background— Angiotensin-converting enzyme inhibitor therapy improves clinical outcome and ventricular function in adults with heart failure. Infants single-ventricle physiology have poor growth are at risk for abnormalities systolic diastolic function. The ability of angiotensin-converting to preserve improve somatic outcomes these infants is unknown. Methods Results— Pediatric Heart Network conducted a double-blind trial involving 230 randomized receive enalapril (target dose 0.4 mg · kg −1...
Background: In the SVR trial (Single Ventricle Reconstruction), 1-year transplant-free survival was better for Norwood procedure with right ventricle-to-pulmonary artery shunt (RVPAS) compared a modified Blalock–Taussig in patients hypoplastic left heart and related syndromes. At 6 years, we other outcomes between groups. Methods: Medical history collected annually using medical record review, telephone interviews, death index. The cohort included 549 randomized treated trial. Results:...
Background— In the Single Ventricle Reconstruction (SVR) trial, 1-year transplantation-free survival was better for Norwood procedure with right ventricle–to–pulmonary artery shunt (RVPAS) compared a modified Blalock-Taussig (MBTS). At 3 years, we survival, echocardiographic ventricular ejection fraction, and unplanned interventions in treatment groups. Methods Results— Vital status medical history were ascertained from annual records, death indexes, phone interviews. The cohort included 549...
The impact of pulmonary valve replacement (PVR) on major adverse clinical outcomes in patients with repaired tetralogy Fallot (rTOF) is unknown. purpose this study was to determine whether PVR associated improved survival and freedom from sustained ventricular tachycardia (VT) rTOF. A propensity score created adjust for baseline differences between non-PVR enrolled INDICATOR (International Multicenter TOF Registry). primary outcome time the earliest occurrence death or VT. were matched 1:1...
OBJECTIVES We wished to assess the profile and outcomes of patients with ventricular septal rupture (VSR) in setting cardiogenic shock (CS) complicating acute myocardial infarction (MI). BACKGROUND Cardiogenic is often seen VSR MI. Despite surgical therapy, mortality such high. METHODS analyzed 939 enrolled SHOCK Trial Registry CS infarction, comparing 55 whose was associated 884 who had predominant left failure. RESULTS Rupture occurred a median 16 h after infarction. Patients tended be...