A5083380176- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Congenital Heart Disease Studies
- Renal Transplantation Outcomes and Treatments
- Congenital Diaphragmatic Hernia Studies
- Tissue Engineering and Regenerative Medicine
- Heart Failure Treatment and Management
- Immunodeficiency and Autoimmune Disorders
- Cardiac electrophysiology and arrhythmias
- Pneumocystis jirovecii pneumonia detection and treatment
- Blood disorders and treatments
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiomyopathy and Myosin Studies
- Congenital heart defects research
- Viral-associated cancers and disorders
- Pneumonia and Respiratory Infections
- Adolescent and Pediatric Healthcare
- Blood Coagulation and Thrombosis Mechanisms
- COVID-19 and healthcare impacts
- Healthcare Policy and Management
- Cardiac Fibrosis and Remodeling
- Takotsubo Cardiomyopathy and Associated Phenomena
- Parvovirus B19 Infection Studies
Johns Hopkins All Children's Hospital
2016-2025
Johns Hopkins University
2016-2025
Children's Center
2025
Johns Hopkins Medicine
2022
Phoenix Children's Hospital
2021
Children’s Institute
2017
Institute of Cardiology
2015
AdventHealth for Children
2015
University of South Florida St. Petersburg
2002-2012
Florida College
2012
With continued medical and surgical advancements, most children adolescents with congenital heart disease are expected to survive adulthood. Chronic failure is increasingly being recognized as a major contributor ongoing morbidity mortality in this population it ages, treatment strategies prevent treat the pediatric needed. In addition primary myocardial dysfunction, anatomical pathophysiological abnormalities specific various lesions contribute development of affect potential commonly used...
This expert review seeks to highlight implicit bias in health care, transplant medicine, and pediatric heart transplantation focus attention on the role these biases may play racial/ethnic socioeconomic disparities noted transplantation. breaks down decision making process points at which affect outcomes discuss how science of human help understand complex processes.
ABSTRACT Background Short‐term outcomes following heart transplantation in children have improved, but comparable improvements long‐term survival continues to barriers. We sought investigate and identify protective risk factors associated with children. Methods The Pediatric Heart Transplant Society (PHTS) database was queried for transplant recipients from 1993 2010 who were ≤ 10 years of age at time transplant. Patients conditional graft > 3 ≥ analyzed. Survival time‐to‐event compared...
Abstract Hypoplastic left heart syndrome (HLHS) is a congenital malformation commonly treated with palliative surgery and associated significant morbidity mortality. Risk stratification models have often relied upon traditional survival analyses or outcomes data failing to extend beyond infancy. Individualized prediction of transplant-free (TFS) employing machine learning (ML) based infancy may provide further valuable insight for families healthcare providers along the course staged...
Objective: Orthotopic heart transplantation is considered a rescue option for children with failing staged palliation or repair of hypoplastic left syndrome. We present our strategy management, and outcomes, these complex patients. Methods: transplanted 68 consecutive children, diagnoses syndrome in 31, cardiomyopathy 20, post-operative congenital disease 17. Of patients, 9 (13.2%) were neonates, 46 (67.6%) infants. Median age was 118.5 days. Operative technique involves bicaval cannulation...
Background Infants with heart failure remain at significant risk for wait list mortality, despite mechanical circulatory support (MCS). It is unclear if the outcomes are influenced by modality of or underlying diagnosis. We sought to compare infants <10 kg, focusing on and Methods Results Using Pediatric Heart Transplant Society database, we evaluated survival following first MCS device in children kg who were listed transplant between 2010 2018. There 2049 predominant diagnosis being...
Abstract Background The Pediatric Heart Transplant Society (PHTS) Registry was founded 30 years ago as a collaborative effort among like‐minded providers of this novel life‐saving technique for children with end‐stage heart failure. In the intervening decades, data from have provided invaluable knowledge to field pediatric transplantation. This report PHTS provides comprehensive look at data, highlighting both longevity registry and one unique aspect registry, allowing exploration into...
Abstract Heart failure is a leading cause of death worldwide. Current therapies only delay progression the cardiac disease or replace diseased heart with transplantation. Stem cells represent recently discovered novel approach to treatment that may facilitate replacement tissue and subsequently lead improved function regeneration. A stem cell defined as properties being clonogenic, self-renewing, multipotent. In response intercellular signalling environmental stimuli, differentiate into...
There are only a few reports of successful use mammalian target rapamycin (mTORI) as primary immunosuppression in pediatric heart transplantation. Compared to calcineurin inhibitors, mTORI have less side effects, especially nephrotoxicity, infections, and malignancies. A retrospective study was conducted at our institution all 170 transplants from 1995 2015. Nineteen patients were switched tacrolimus (n=15) or cyclosporin (n=4) everolimus sirolimus due nephrotoxicity (n=5), malignancy (n=8),...