A5071623852- Renal Transplantation Outcomes and Treatments
- Cardiomyopathy and Myosin Studies
- Congenital Heart Disease Studies
- Smoking Behavior and Cessation
- Noise Effects and Management
- School Health and Nursing Education
- Cardiovascular Function and Risk Factors
- Breast Implant and Reconstruction
- HIV/AIDS drug development and treatment
- Acne and Rosacea Treatments and Effects
- Cancer survivorship and care
- Organ Transplantation Techniques and Outcomes
- Williams Syndrome Research
- Reconstructive Surgery and Microvascular Techniques
- Health and Wellbeing Research
- Air Quality and Health Impacts
- Congenital Diaphragmatic Hernia Studies
- Hematopoietic Stem Cell Transplantation
- Adolescent and Pediatric Healthcare
- Cardiovascular Effects of Exercise
- Trypanosoma species research and implications
- Transplantation: Methods and Outcomes
- Cardiac Valve Diseases and Treatments
- Nuclear Receptors and Signaling
- Intergenerational Family Dynamics and Caregiving
Hospital for Sick Children
2018-2025
SickKids Foundation
2018-2024
University of Nursing Yangon
2020
Creative Commons
2020
University of Toronto
2018
Canadian Natural Resources
2018
University of Auckland
2011
University Health Network
2011
For this study, the authors evaluated early psychosocial adjustments and health-related quality-of-life changes after breast reconstruction.All consecutive patients who underwent reconstruction between June 2009 November 2010 were asked to complete BREAST-Q, Hospital Anxiety Depression Scale (HADS), Impact of Event (IES) questionnaires before surgery at 3 weeks months surgery. A repeated-measures design was used compare scores baseline postoperative time points.Fifty-one 55 women completed...
Genetic defects in the RAS/mitogen-activated protein kinase pathway are an important cause of hypertrophic cardiomyopathy (RAS-HCM). Unlike primary HCM (P-HCM), risk sudden cardiac death (SCD) and long-term survival RAS-HCM poorly understood.The study's objective was to compare transplant-free survival, incidence SCD, implantable cardioverter-defibrillator (ICD) use between P-HCM patients.In international, 21-center cohort study, we analyzed phenotype-positive pediatric (n = 188) 567)...
Hypertrophic cardiomyopathy (HCM) can be associated with an abnormal exercise response. In adults HCM, results on stress testing are predictive of heart failure outcomes. Our goal was to determine whether response is adverse outcomes in pediatric patients HCM. international cohort study including 20 centers, phenotype-positive primary HCM who were <18 years age at diagnosis included. Abnormal defined as a blunted blood pressure and new or worsened ST- T-wave segment changes complex...
Abstract Background Tacrolimus pharmacokinetics are influenced by age and CYP 3A5 genotype with expressors ( 3A5*1/*1 or *1/*3 ) being fast metabolizers. However, the benefit of genotype‐guided dosing in pediatric solid organ transplantation has been understudied. Objective To determine whether starting dose tacrolimus result earlier attainment therapeutic drug concentrations. Setting Single hospital‐based transplant center. Methods This was a randomized, semi‐blinded, 30‐day pilot trial....
Elastin insufficiency causes recurrent vascular stenoses. Hemizygous deletion of the elastin gene (ELN) Williams-Beuren syndrome (WBS), while single nucleotide variants in ELN cause nonsyndromic supravalvar aortic stenosis (SVAS). Our objective was to compare cardiovascular disease outcomes patients with WBS and SVAS.Patients (81 WBS, 42 SVAS) were included this retrospective center study. Freedom from surgical catheter interventions reinterventions compared. Vascular tissue 8 6 controls...
Background. There are challenges in achieving and maintaining therapeutic tacrolimus levels after solid organ transplantation (SOT). The purpose of this genome-wide association study was to generate an integrated clinical genetic prediction model for pediatric SOT. Methods. In a multicenter prospective observational cohort (2015–2018), children <18 years old at their first SOT receiving as maintenance immunosuppression were included (455 discovery cohort; 322 validation cohort)....
Despite age-related differences in biology, physiology, and behavior, transplant immunosuppression is not tailored by age. This likely contributes to high graft failure posttransplant complications. We present the aims, design, methods of Pediatric Outcomes Transplant: PersOnaliSing Immunosuppression To ImproVe Efficacy Study aimed at personalizing children young adults.
Issue addressed New Zealand's (NZ) smokefree legislation, implemented on 1 January 2004, requires that all school and early childhood centre buildings grounds are 100% smokefree; one aim being to prevent young people influenced by seeing (including teachers) smoke there. This study, conducted in 2008, investigated teachers' smoking behaviour perceived adherence the legislation. Methods A national NZ cross-sectional survey of 2,004 teachers (oversampling Mori), who were randomly selected from...
Issue addressed Despite the established risks associated with smoking, 21% of New Zealand adults smoke. Prevalence among Mori (indigenous) and Pacific Island Zealanders is disproportionately high. Prevention smoking initiation a key component tobacco control. Keeping Kids Smokefree – quasi-experimental trial aimed to do this by changing parental behaviour attitudes. However, little known about parents' attitudes in comparison other concerns. Method Parents 4,144 children attending five urban...
Background: With the increasing needs of aging population and prevalence non-communicable diseases, assessment equity accessibility health care among elderly has become important.
Introduction: Hypertrophic cardiomyopathy (HCM) can be associated with an abnormal exercise response. In adults HCM, stress test (EST) is predictive of heart failure outcomes. Our goal was to determine if response adverse outcomes in pediatric HCM patients. Methods: : international cohort study 20 centers (PRIMaCY), children <18 years primary were included. Abnormal EST defined as rate or blood pressure response, arrhythmias and/or ischemic ECG changes on exercise. Sudden cardiac death...
Introduction: Motile ciliary dysfunction plays a central role in the pathogenesis of respiratory abnormalities and congenital heart disease (CHD). The gene variants non-heterotaxic CHD population is not well characterised. Methods: This single-centre retrospective cohort study aimed to determine prevalence Primary Ciliary Dyskinesia (PCD) children with isolated Transposition Great Arteries (TGA) Tetralogy Fallot (TOF). Patients whole genome sequencing between 2008-2018 were included. We...