A5053213573- Congenital Heart Disease Studies
- Transplantation: Methods and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Renal Transplantation Outcomes and Treatments
- Mechanical Circulatory Support Devices
- Aortic Disease and Treatment Approaches
- Viral Infections and Immunology Research
- Cardiomyopathy and Myosin Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Bone health and osteoporosis research
- Organ Transplantation Techniques and Outcomes
- Cardiac Arrest and Resuscitation
- Pulmonary Hypertension Research and Treatments
- Congenital heart defects research
- Cardiac pacing and defibrillation studies
- Bone health and treatments
- Cardiovascular Issues in Pregnancy
- Cardiac Ischemia and Reperfusion
- Coronary Artery Anomalies
- Neonatal Respiratory Health Research
Ted Rogers Centre for Heart Research
2018-2025
University Health Network
2018-2025
Hospital for Sick Children
2016-2025
SickKids Foundation
2016-2025
First Affiliated Hospital of GuangXi Medical University
2025
Guangxi Medical University
2025
Health Net
2023-2025
Zunyi Medical University
2025
University of Toronto
2011-2024
Toronto General Hospital
2017-2024
The early genetic pathway(s) triggering the pathogenesis of coronary artery disease (CAD) and myocardial infarction (MI) remain largely unknown. Here, we describe an autosomal dominant form CAD/MI (adCAD1) that is caused by deletion seven amino acids in transcription factor MEF2A. disrupts nuclear localization MEF2A, reduces MEF2A-mediated activation, abolishes synergistic activation MEF2A GATA-1 through a dominant-negative mechanism. protein demonstrates strong expression endothelium...
Hypertrophic cardiomyopathy is the leading cause of sudden cardiac death (SCD) in children and young adults. Our objective was to develop validate a SCD risk prediction model pediatric hypertrophic guide prevention strategies. In an international multicenter observational cohort study, phenotype-positive patients with isolated <18 years age at diagnosis were eligible. The primary outcome variable time from composite events 5-year follow-up: SCD, resuscitated arrest, aborted that is,...
Background: Currently, women represent <25% of heart transplant recipients. Reasons for this female underrepresentation have been attributed to selection and referral bias potentially poorer outcomes in The aim study was compare long-term posttransplant survival between men women, when matched recipient donor characteristics. Methods Results: Using the International Society Heart Lung Transplantation Registry, we performed descriptive analyses estimated overall freedom from death...
There is a growing interest in understanding whether cardiovascular magnetic resonance (CMR) myocardial tissue characterization helps identify risk of cancer therapy-related cardiac dysfunction (CTRCD).
Guideline-directed medical therapy (GDMT) remains underutilized in patients with heart failure reduced ejection fraction, leading to morbidity and mortality. The Medly Titrate (Use of Telemonitoring Facilitate Heart Failure Mediation Titration) study was an open-label, randomized controlled trial determine whether remote medication titration for fraction more effective than usual care (UC). In this study, 108 were GDMT through the program (n = 56) vs UC 52). primary outcome proportion...
Understanding phenotypic variations in left ventricular (LV) dysfunction during cancer therapy may allow for tailored surveillance and prevention. The study sought to determine LV phenotypes their interrelated-ness association with therapy-related cardiac (CTRCD), myocardial tissue changes, blood biomarkers. This is a secondary analysis of the EMBRACE-MRI (Evaluation Myocardial Changes During BReast Adenocarcinoma Therapy Detect Cardiotoxicity Earlier With MRI) which women early-stage HER2+...
Diagnosis of cancer therapy-related cardiac dysfunction (CTRCD) remains a challenge. Cardiovascular magnetic resonance (CMR) provides accurate measurement left ventricular ejection fraction (LVEF), but access to repeated scans is limited.
Genetic defects in the RAS/mitogen-activated protein kinase pathway are an important cause of hypertrophic cardiomyopathy (RAS-HCM). Unlike primary HCM (P-HCM), risk sudden cardiac death (SCD) and long-term survival RAS-HCM poorly understood.The study's objective was to compare transplant-free survival, incidence SCD, implantable cardioverter-defibrillator (ICD) use between P-HCM patients.In international, 21-center cohort study, we analyzed phenotype-positive pediatric (n = 188) 567)...
TBX5 is a T-box transcription factor that plays critical role in organogenesis. Seven missense mutations have been identified patients with Holt-Oram syndrome characterized by congenital heart defects and upper limb abnormalities. However, the functional significance molecular pathogenic mechanisms of these are not clear. In this study we describe DNA binding, transcriptional activity, protein-protein interaction, cellular localization mutant (Q49K, I54T, G80R, G169R, R237Q, R237W, S252I)....
Coronary artery disease (CAD), including its most serious complication myocardial infraction (MI), is the leading cause of death in US and developed countries. We recently discovered that a seven-amino acid deletion MEF2A, transcription factor with high level expression endothelium coronary arteries, co-segregates CAD/MI one family, it suppresses activation activity MEF2A by dominant-negative mechanism. In this study, we used single-strand conformation polymorphism DNA sequence analyses to...
Objectives Mortality associated with the modified Blalock–Taussig shunt (MBTS) remains high despite advanced perioperative management. This study was formulated to provide data on (1) current indications, (2) outcomes, and (3) factors affecting mortality morbidity. Design A retrospective single center chart review identified 95 children (excluding hypoplastic left heart lesions) requiring a MBTS. major morbidity were analyzed using Kaplan Meier method risk factor analysis Cox's proportional...
Background The relative impact of right ventricular ( RV ) electromechanical dyssynchrony versus pulmonary regurgitation PR on exercise capacity and function after tetralogy Fallot repair is unknown. We aimed to delineate the effects these factors capacity. Methods Results retrospectively analyzed 81 children with using multivariable regression. Predictor parameters were electrocardiographic QRS duration reflecting severity by cardiac magnetic resonance. outcome (percentage predicted peak...
Endothelial cell (EC) activation, endotheliitis, vascular permeability, and thrombosis have been observed in patients with severe coronavirus disease 2019 (COVID-19), indicating that the vasculature is affected during acute stages of SARS-CoV-2 infection. It remains unknown whether circulating markers are sufficient to predict clinical outcomes, unique COVID-19, if permeability can be therapeutically targeted.Prospectively evaluating prevalence inflammatory, cardiac, EC activation as well...
Anti-Ro antibody-positive mothers are frequently referred for serial echocardiography due to the fetal risk of developing heart block and endocardial fibroelastosis. Little is known why only some not all offspring develop these cardiac manifestations neonatal lupus (CNL). This prospective study examined associations between anti-Ro antibody titers CNL.Antibody-positive since 2018 at CNL (group 1; n = 240) or with 2; 18) were included. Maternal measured a chemiluminescent immunoassay (CIA)....