María Gallego‐Delgado
A5021837056- Cardiomyopathy and Myosin Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Parathyroid Disorders and Treatments
- Viral Infections and Immunology Research
- Cardiovascular Function and Risk Factors
- Sarcoidosis and Beryllium Toxicity Research
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Advanced MRI Techniques and Applications
- Eosinophilic Disorders and Syndromes
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Pancreatitis Pathology and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Neurogenetic and Muscular Disorders Research
- Congenital heart defects research
- Mitochondrial Function and Pathology
- Cardiovascular Disease and Adiposity
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced X-ray and CT Imaging
- Williams Syndrome Research
- Vasculitis and related conditions
Complejo Hospitalario de Salamanca
2012-2025
Instituto de Investigación Biomédica de Salamanca
2017-2025
Universidad de Salamanca
2018-2025
Instituto de Salud Carlos III
2017-2025
Centro de Investigación Biomédica en Red
2018-2025
Centro de Investigación en Red en Enfermedades Cardiovasculares
2017-2025
Instituto de Estudios de Ciencias de la Salud de Castilla y León
2024
Associazione Nazionale Medici Cardiologi Ospedalieri
2024
European Society of Cardiology
2024
Junta de Castilla y León
2024
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous clinical syndrome multiple underlying causes. Wild-type transthyretin (TTR) amyloidosis (ATTRwt) an underdiagnosed cause of HFpEF that might benefit from new specific treatments. ATTRwt can be diagnosed non-invasively by 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (99mTc-DPD) scintigraphy. We sought to determine the prevalence among elderly patients admitted due HFpEF. prospectively screened all consecutive ≥60...
Background: Identification of people with hypertrophic cardiomyopathy (HCM) who are at risk sudden cardiac death (SCD) and require a prophylactic implantable cardioverter defibrillator is challenging. In 2014, the European Society Cardiology proposed new stratification method based on prediction model (HCM Risk-SCD) that estimates 5-year SCD. The aim was to externally validate 2014 recommendations in geographically diverse cohort patients recruited from United States, Europe, Middle East,...
Background: Truncating variants in the TTN gene (TTNtv) are commonest cause of heritable dilated cardiomyopathy. This study aimed to phenotypes and outcomes TTNtv carriers. Methods: Five hundred thirty-seven individuals (61% men; 317 probands) with were recruited 14 centers (372 [69%] baseline left ventricular systolic dysfunction [LVSD]). Baseline longitudinal clinical data obtained. The primary end point was a composite malignant arrhythmia end-stage heart failure. secondary reverse...
Variants in myosin heavy chain 7 (MYH7) are responsible for disease 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history MYH7-related DCM poorly described.We sought determine phenotype prognosis DCM. We also evaluated influence variant location on phenotypic expression.We studied data from 147 individuals DCM-causing MYH7 variants (47.6% female; 35.6 ± 19.2 years) recruited 29 international centers.At initial evaluation, 106...
Although genotyping allows family screening and influences risk-stratification in patients with nonischemic dilated cardiomyopathy (DCM) or isolated left ventricular systolic dysfunction (LVSD), its result is negative a significant number of patients, limiting widespread adoption. This study sought to develop externally validate score that predicts the probability for positive genetic test (G+) DCM/LVSD. Clinical, electrocardiogram, echocardiographic variables were collected 1,015 genotyped...
Abstract Aims Late gadolinium enhancement (LGE) is frequently found in patients with dilated cardiomyopathy (DCM); there little information about its frequency and distribution pattern according to the underlying genetic substrate. We sought describe LGE patterns genotypes analyse risk of major ventricular arrhythmias (MVA) patterns. Methods results Cardiac magnetic resonance findings genetics were performed a cohort 600 DCM followed at 20 Spanish centres. After exclusion individuals...
Disease penetrance in genotype-positive (G+) relatives of families with dilated cardiomyopathy (DCM) and the characteristics associated DCM onset these individuals are unknown. This study sought to determine new diagnosis G+ identify factors development. The authors evaluated 779 patients (age 35.8 ± 17.3 years; 459 [59%] females; 367 [47%] variants TTN) without followed at 25 Spanish centers. After a median follow-up 37.1 months (Q1-Q3: 16.3-63.8 months), 85 (10.9%) developed (incidence...
BACKGROUND: Less than 40% of patients with dilated cardiomyopathy (DCM) have a pathogenic/likely pathogenic genetic variant identified. TBX20 has been linked to congenital heart defects; although an association left ventricular noncompaction (LVNC) and DCM proposed, it is still considered gene limited evidence for these phenotypes. This study sought investigate the between truncating ( TBX20tv ) DCM/LVNC. METHODS: was sequenced by next-generation sequencing in 7463 unrelated probands...
Genetic disease has recently emerged as a cause of cardiac conduction disorders (CCDs), but the diagnostic yield genetic testing and contribution different genes to CCD is still unsettled. This study sought determine in young adults with unknown etiology requiring pacemaker implantation. We also studied prevalence rare protein-altering variants across individual functional gene groups. performed whole exome sequencing 150 patients who had permanent implanted at age ≤60 years 14 Spanish...
To describe the natural history of SARS-CoV-2 infection in patients with hypertrophic cardiomyopathy (HCM) compared a control group and to identify predictors adverse events.
Transthyretin cardiac amyloidosis (ATTR-CA) is increasingly recognized as a treatable form of heart failure. Atrial fibrillation (AF) common in patients with ATTR-CA. Whether recent-onset AF can be used an early marker to identify ATTR-CA has not been elucidated.
A novel rare mutation in the pore region of Nav1.5 channels (p.L889V) has been found three unrelated Spanish families that produces quite diverse phenotypic manifestations (Brugada syndrome, conduction disease, dilated cardiomyopathy, sinus node dysfunction, etc.) with variable penetrance among families. We clinically characterized carriers and recorded Na+ current (INa) generated by p.L889V native (WT) channels, alone or combination, to obtain further insight into genotypic–phenotypic...
Background Hypertrophic cardiomyopathy (HCM) is an inherited disorder whose causal variants involve sarcomeric protein genes. One of these myosin-binding C (MYBPC3), being previously associated with a favourable prognosis. Our objective to describe the clinical characteristics and events molecularly homogeneous HCM cohort truncating MYBPC3 variants. Methods results A patients relatives diagnosis carrying variant were retrospectively recruited. Subjects had average follow-up 7.77 years,...