Marta Cobo Marcos
A5021208317- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Cardiac pacing and defibrillation studies
- Cardiomyopathy and Myosin Studies
- Potassium and Related Disorders
- Cardiac Structural Anomalies and Repair
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Atrial Fibrillation Management and Outcomes
- Electrolyte and hormonal disorders
- Hemodynamic Monitoring and Therapy
- Cardiovascular Effects of Exercise
- Viral Infections and Immunology Research
- Blood Pressure and Hypertension Studies
- Renal function and acid-base balance
- Dialysis and Renal Disease Management
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Particle physics theoretical and experimental studies
- Mechanical Circulatory Support Devices
- Transplantation: Methods and Outcomes
- Eosinophilic Disorders and Syndromes
- Peptidase Inhibition and Analysis
- Ultrasound in Clinical Applications
Hospital Universitario Puerta de Hierro Majadahonda
2015-2025
Centro de Investigación Biomédica en Red
2017-2025
Universidad Autónoma de Madrid
2007-2025
Instituto de Salud Carlos III
2019-2025
Instituto de Física Teórica
2025
Centro de Investigación en Red en Enfermedades Cardiovasculares
2017-2024
European Society of Cardiology
2018-2024
Associazione Nazionale Medici Cardiologi Ospedalieri
2018-2024
Centro Nacional de Microbiologia
2024
ERN GUARD-Heart
2024
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous clinical syndrome multiple underlying causes. Wild-type transthyretin (TTR) amyloidosis (ATTRwt) an underdiagnosed cause of HFpEF that might benefit from new specific treatments. ATTRwt can be diagnosed non-invasively by 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (99mTc-DPD) scintigraphy. We sought to determine the prevalence among elderly patients admitted due HFpEF. prospectively screened all consecutive ≥60...
Wild-type transthyretin amyloidosis (ATTRwt) is mostly considered a disease predominantly of elderly male, characterized by concentric LV hypertrophy, preserved LVEF, and low QRS voltages. We sought to describe the characteristics large cohort ATTRwt patients better define disease.Clinical findings consecutive diagnosed at 2 centres were reviewed. was histologically or non-invasively (LV hypertrophy ≥12 mm, intense cardiac uptake 99mTc-DPD scintigraphy AL exclusion). Mutations in TTR...
Background: The use of urinary sodium to guide diuretics in acute heart failure is recommended by experts and the most recent European Society Cardiology guidelines. However, there are limited data support this recommendation. ENACT-HF study (Efficacy a Standardized Diuretic Protocol Acute Heart Failure) investigated feasibility efficacy standardized natriuresis-guided diuretic protocol patients with signs volume overload. Methods: was an international, multicenter, open-label, pragmatic,...
Variants in myosin heavy chain 7 (MYH7) are responsible for disease 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history MYH7-related DCM poorly described.We sought determine phenotype prognosis DCM. We also evaluated influence variant location on phenotypic expression.We studied data from 147 individuals DCM-causing MYH7 variants (47.6% female; 35.6 ± 19.2 years) recruited 29 international centers.At initial evaluation, 106...
ABSTRACT Aims Dapagliflozin improves the prognosis of patients with heart failure (HF), regardless left ventricular ejection fraction (LVEF). However, its effect on cardiac remodelling parameters, specifically atrial (LA) remodelling, is not well established. Methods and results The DAPA‐MODA trial (NCT04707352) a multicentre, single‐arm, open‐label, prospective interventional study that aimed to evaluate dapagliflozin parameters over 6 months. Patients stable chronic HF receiving optimized...
Hypertonic saline solution (HSS) plus intravenous (IV) loop diuretic appears to enhance the response in patients hospitalized for heart failure (HF). The efficacy and safety of this therapy ambulatory setting have not been evaluated. We aimed describe design baseline characteristics SALT-HF trial participants.
<h3>Backgroud</h3> Idiopathic dilated cardiomyopathy (DCM) is the most frequent indication for orthotopic heart transplantation. It has been suggested that mutations in genes encoding desmosomal proteins, more typically associated with arrhythmogenic right ventricular cardiomyopathy, are a cause of DCM. <h3>Objectives</h3> To determine frequency protein gene transplant recipients and their families to examine histopathological characteristics explanted organs from mutation carriers....
Abstract Aims Transthyretin amyloid cardiomyopathy (ATTR‐CM) is increasingly recognized as a cause of heart failure in the elderly. Although wild‐type transthyretin amyloidosis most frequent form ATTR‐CM found elderly, hereditary (ATTRv) can also occur. We sought to determine prevalence ATTRv among elderly patients, identify predictors and evaluate clinical consequences positive genetic testing this population. Methods results Prevalence patients (≥70 years) was assessed cohort 300...
Mortality and re-admission rates for decompensated acute heart failure (AHF) is increasing overall risk stratification might be challenging. We sought to evaluate the prognostic role of systemic venous ultrasonography in patients hospitalized AHF. prospectively recruited 74 AHF with a NT-proBNP level above 500 pg/mL. Then, multi-organ ultrasound assessments (lung, inferior vena cava (IVC), pulsed-wave Doppler (PW-Doppler) hepatic, portal, intra-renal femoral veins) were performed at...
Mineralocorticoid receptor antagonists (MRA) improve outcomes in patients with heart failure and reduced ejection fraction (HFrEF) but are underused clinical practice. Observational data suggest that hyperkalemia is the leading obstacle for suboptimal use of MRA.
Objective: Cardiac amyloid infiltration can lead to systolic heart failure (HF) or conduction disorders (CD). Patients with transthyretin (ATTR) amyloidosis are particularly exposed. We sought determine the prevalence of ATTR and AL among patients >60 years admitted CD unexplained HF increased wall thickness. Materials Methods: studied 143 (57% males, 79 ± 9 years) (N = 28) requiring pacemaker implantation 115). In total, 139 (97%) (28 111 CD) underwent 99mTc-DPD scintigraphy detect ATTR,...
Abstract Aim Patients with advanced heart failure (AHF) who are not candidates to therapies have poor prognosis. Some trials shown that intermittent levosimendan can reduce HF hospitalizations in AHF the short term. In this real‐life registry, we describe patterns of use, safety and factors related response infusions patients therapies. Methods results Multicentre retrospective study diagnosed failure, HT or LVAD candidates. needed be on optimal medical therapy according their treating...
Although acute heart failure (AHF) with volume overload is treated loop diuretics, their dosing and type of administration are mainly based upon expert opinion. A recent position paper from the Heart Failure Association (HFA) proposed a step-wise pharmacologic diuretic strategy to increase response achieve rapid decongestion. However, no study has evaluated this protocol prospectively.