A5017153998- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiomyopathy and Myosin Studies
- Transplantation: Methods and Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Heart Failure Treatment and Management
- Mechanical Circulatory Support Devices
- Cardiovascular Function and Risk Factors
- Parathyroid Disorders and Treatments
- Cardiovascular Effects of Exercise
- Cardiovascular Issues in Pregnancy
- Eosinophilic Disorders and Syndromes
- Protein Kinase Regulation and GTPase Signaling
- Atrial Fibrillation Management and Outcomes
- Peptidase Inhibition and Analysis
- Cardiac electrophysiology and arrhythmias
- Sarcoidosis and Beryllium Toxicity Research
- Renal Transplantation Outcomes and Treatments
- Venous Thromboembolism Diagnosis and Management
- Intensive Care Unit Cognitive Disorders
- Congenital heart defects research
- Viral Infections and Immunology Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Arrhythmias and Treatments
- Acute Myocardial Infarction Research
Centro de Investigación en Red en Enfermedades Cardiovasculares
2022-2025
Bellvitge University Hospital
2018-2025
Institut d'Investigació Biomédica de Bellvitge
2021-2025
Hospital Universitario Puerta de Hierro Majadahonda
2022-2024
Centro de Investigación Biomédica en Red
2022-2024
Spanish National Centre for Cardiovascular Research
2023-2024
Instituto de Salud Carlos III
2022-2024
ERN GUARD-Heart
2022-2024
Universitat de Barcelona
2023
Universidad de Navarra
2014
Variants in myosin heavy chain 7 (MYH7) are responsible for disease 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history MYH7-related DCM poorly described.We sought determine phenotype prognosis DCM. We also evaluated influence variant location on phenotypic expression.We studied data from 147 individuals DCM-causing MYH7 variants (47.6% female; 35.6 ± 19.2 years) recruited 29 international centers.At initial evaluation, 106...
Abstract Aims Transthyretin amyloid cardiomyopathy (ATTR‐CM) is increasingly recognized as a cause of heart failure in the elderly. Although wild‐type transthyretin amyloidosis most frequent form ATTR‐CM found elderly, hereditary (ATTRv) can also occur. We sought to determine prevalence ATTRv among elderly patients, identify predictors and evaluate clinical consequences positive genetic testing this population. Methods results Prevalence patients (≥70 years) was assessed cohort 300...
Abstract Aim Patients with advanced heart failure (AHF) who are not candidates to therapies have poor prognosis. Some trials shown that intermittent levosimendan can reduce HF hospitalizations in AHF the short term. In this real‐life registry, we describe patterns of use, safety and factors related response infusions patients therapies. Methods results Multicentre retrospective study diagnosed failure, HT or LVAD candidates. needed be on optimal medical therapy according their treating...
Variants in
Abstract Background There is an urgent need to improve the risk-stratification for ventricular arrhythmias (VA) and sudden death (SD) in non-ischaemic cardiomyopathy (NICM), moving beyond left ejection fraction (LVEF). Late gadolinium enhancement (LGE) at cardiac magnetic resonance (CMR) a strong independent predictor of VA SD NICM. However, it necessary find additional predictors on top LGE essential further refine risk stratification within higher-risk LGE+ cases. Atrioventricular block...
In May 2016, a new version of the European Society Cardiology (ESC) Guidelines for management heart failure (HF) was released. The aim this study to describe HF with reduced ejection fraction after publication ESC Guidelines.
Background The p.Glu109Lys variant (Glu89Lys) is a rare cause of hereditary transthyretin amyloidosis (ATTRv) for which clinical spectrum remains unresolved. We sought to describe the characteristics and outcomes ATTR Glu89Lys assess potential founder effect in Spain.Methods Patients with ATTRv from 14 families were recruited at 7 centres. Demographics, complementary tests course analysed. Haplotype analysis was performed unrelated individuals.Results Thirty-eight individuals (13 probands,...
Objective We sought to investigate prevalence, incidence and prognostic implications of permanent pacemaker (PPM) implantation in patients with cardiac amyloidosis (CA), thereby identifying the predictors time PPM implantation. Methods Seven hundred eighty-seven CA (602 men, median age 74 years, 571 transthyretin (ATTR), 216 light-chain (AL)) evaluated at two European referral centres were retrospectively included. Clinical, laboratory instrumental data analysed. The associations between...
The prevalence of advanced heart failure (HF) is increasing due to the growing number patients with HF and their better treatment survival. There a scarcity data on accuracy web-based risk scores in this selected population. This study aimed assess mortality prediction performance Meta-Analysis Global Group Chronic (MAGGIC-HF) score model Barcelona Bio-HF Risk Calculator (BCN-Bio-HF) containing N terminal pro brain natriuretic peptide receiving intermittent inotropic support levosimendan as...