A5066986112- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Cardiac Structural Anomalies and Repair
- Cardiomyopathy and Myosin Studies
- Cardiac pacing and defibrillation studies
- Viral Infections and Immunology Research
- Cardiac Arrhythmias and Treatments
- Fermentation and Sensory Analysis
- Lysosomal Storage Disorders Research
- Transplantation: Methods and Outcomes
- Heart Failure Treatment and Management
- HIV Research and Treatment
- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- Blood Pressure and Hypertension Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- HIV/AIDS drug development and treatment
- Pericarditis and Cardiac Tamponade
- Cardiac Valve Diseases and Treatments
- Cardiovascular Effects of Exercise
- Advanced X-ray and CT Imaging
- Horticultural and Viticultural Research
- Cardiovascular and exercise physiology
- Radiation Dose and Imaging
Wythenshawe Hospital
2014-2025
University of Manchester
2015-2025
Manchester University NHS Foundation Trust
2016-2025
Australian Centre for Heart Health
2023-2025
Manchester Academic Health Science Centre
2015-2024
Hochschule Geisenheim University
2014-2023
Fraunhofer Institute for Casting, Composite and Processing Technology IGCV
2022
Cardiovascular Research Center
2018-2021
Universitätsklinikum Würzburg
2020
University of Edinburgh
2004-2020
Extracellular matrix expansion is a key element of ventricular remodeling and potential therapeutic target. Cardiovascular magnetic resonance (CMR) T1-mapping techniques are increasingly used to evaluate myocardial extracellular volume (ECV); however, the most widely applied methods without histological validation. Our aim was perform comprehensive validation (1) dynamic-equilibrium CMR (DynEq-CMR), where ECV quantified using hematocrit-adjusted blood T1 values measured before after...
Background Myocardial fibrosis ( MF ) in noninfarcted myocardium may be an interstitial disease pathway that confers vulnerability to hospitalization for heart failure, death, or both across the spectrum of failure and ejection fraction. Hospitalization is epidemic difficult predict prevent requires potential therapeutic targets associated with outcomes. Method Results We quantified cardiovascular magnetic resonance extracellular volume fraction ECV measures 1172 consecutive patients without...
Abstract Coronary artery disease (CAD) is a major cause of ill health and death worldwide. computed tomographic angiography (CCTA) the first-line investigation to detect CAD in symptomatic patients. This diagnostic approach risks greater second-line heart tests treatments at cost patient system. The National Health Service funded use an artificial intelligence (AI) tool, tomography (CT)-derived fractional flow reserve (FFR-CT), patients with chest pain improve physician decision-making...
BACKGROUND Magnetic resonance imaging (MRI) of pacemakers is a relative contraindication because the risks to patient from potentially hazardous interactions between MRI and pacemaker system.Chest scans (ie, cardiac magnetic scans) are particular importance higher risk.The previously Food Drug Administration-approved conditional system includes positioning restrictions, limiting powerful utility MRI.OBJECTIVE To confirm safety effectiveness designed for safe whole body without scan...
We demonstrated previously that endogenous NO influences large-artery distensibility in the ovine hindlimb. However, role of basal larger human conduit arteries is controversial. The aim this study was to investigate whether production NO, acting locally, iliac artery humans. Distensibility assessed by intra-arterial measurement pulse wave velocity. Eighteen subjects, free significant coronary or disease, were studied after diagnostic cardiac catheterization. Simultaneous pressure waveforms...
The persistence of a left-sided superior vena cava is the most common variant systemic venous drainage. Increased utility cardiac imaging, in particular cross-sectional techniques such as computed tomography and magnetic resonance (MR), will result increased detection anomaly its variants. Whilst typical form it often haemodynamically insignificant, discovery may have clinical significance nonetheless, mimics require exclusion. During development results from failure left anterior cardinal...
Incidental coronary and cardiac calcification are frequent findings on non-gated thoracic CT. We recommend that the heart is reviewed all CT scans where it visualised. Coronary artery a marker of disease associated with an adverse prognosis dedicated imaging performed for non-cardiac indications, both without contrast. reported using simple patient-based score (none, mild, moderate, severe). Furthermore, we reports include recommendations subsequent management, namely assessment modifiable...
Arterial stiffness is a key determinant of cardiovascular risk in hypertensive patients. β-Blockers appear to be less effective than other drugs improving outcome patients, and potential explanation may that β-blockers are reducing arterial stiffness. The aim this study was assess the direct effect β-blockade on pulse wave velocity (PWV), robust measure distensibility, using local, ovine, hind-limb model. In addition, we hypothesized vasodilating β-blocker nebivolol, but not atenolol, would...
To assess the impact of "real-world" practice variation in process quantifying left ventricular (LV) mass, volume indices, and ejection fraction (EF) from steady-state free precession cardiovascular magnetic resonance (CMR) images. The utility LV geometric modeling techniques was also assessed.The effect short-axis- versus long-axis-derived base identification, simplified detailed endocardial contouring, visual automated identification end-systole were evaluated using CMR images 50...
Serial surveillance endomyocardial biopsies are performed in patients who have recently undergone heart transplantation order to detect acute cardiac allograft rejection (ACAR) before symptoms occur, however the biopsy process is associated with a number of limitations. This study aimed prospectively and longitudinally evaluate performance multiparametric cardiovascular magnetic resonance (CMR) for detecting monitoring ACAR early phase post-transplant, characterize graft recovery following...
Many efficacious cancer treatments cause significant cardiac morbidity, yet biomarkers or functional indices of early damage, which would allow monitoring and intervention, are lacking. In this study, we have utilized a rat model progressive doxorubicin (DOX)-induced cardiomyopathy, applying multiple approaches, including magnetic resonance imaging (MRI), to provide the most comprehensive characterization date timecourse serological, pathological, events underlying toxicity. Hannover Wistar...
BackgroundIdentifying people who are at risk of being admitted to hospital (hospitalised) for heart failure and death, particularly those have not previously been hospitalised failure, is a priority. We aimed develop externally validate prognostic model involving contemporary deep phenotyping that can be used generate individual estimates hospitalisation or all-cause mortality in patients with, of, but failure.MethodsBetween June 1, 2016, May 31, 2018, 3019 consecutive adult (aged ≥16 years)...
The cardiac manifestations of Fabry disease are the leading cause death, but risk stratification remains inadequate. Identifying patients who at adverse outcome may facilitate more evidence-based treatment guidance. Contemporary cardiovascular magnetic resonance biomarkers have become widely adopted, their prognostic value unclear. objective this study was to develop, internally validate, and evaluate performance of, a model, including contemporary deep phenotyping, which can be used...
IR and Raman spectra (λex = 1064, 400 280 nm) were recorded for solutions of tetracycline several derivatives in acidified alkaline H2O D2O, respectively. Based on the observed resonance enhancement, an empirical assignment most bands wavenumber range 1000 < /cm−1 1600 to either A- or BCD-chromophore could be established. In addition, DFT/BP86 calculations yielded normal mode frequencies coordinates, as well intensities. By comparison these with information contained (especially deuterium...
The Advisa MRI system is designed to safely undergo magnetic resonance imaging (MRI). Its influence on image quality not well known.To evaluate cardiac (CMR) and characterize myocardial contraction patterns by using the system.In this international trial with 35 participating centers, an was implanted in 263 patients. Of those, 177 were randomized group 150 underwent scans at 9-12-week visit. Left ventricular (LV) right (RV) cine long-axis steady-state free precession MR images graded for...
To evaluate the feasibility and accuracy of fusion imaging (FI) during endovascular aneurysm repair (EVAR).FI was performed in 101 consecutive EVAR patients (median age 72 years; 93 men) using automatic registration preoperative computed tomography angiography (CTA) with an intraoperative noncontrast cone beam CT (nCBCT; 3D-3D registration). Operative landmarks defined on CTA were then overlaid 3 dimensions fluoroscopy images. Accuracy measured as deviation position lowest renal artery...
The complexation of various "normal" tetracyclines and anhydrotetracycline with Mg2+ Ca2+ was investigated under physiological conditions (aqueous Tris buffer at pH 7.0 8.5) by spectrometric titration. generated sets UV-Vis absorption fluorescence spectra were analysed two techniques, namely (i) classical evaluation which relies on the occurrence isosbestic points (ii) multivariate fitting employing program Specfit. latter yields not only conditional binding constants, but also, for each...