A5012713546- Antiplatelet Therapy and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Function and Risk Factors
- Fatty Acid Research and Health
- Cardiac Health and Mental Health
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Cardiovascular Disease and Adiposity
- Blood Pressure and Hypertension Studies
- Venous Thromboembolism Diagnosis and Management
- Chronic Disease Management Strategies
- Transplantation: Methods and Outcomes
- Healthcare Systems and Practices
- Atherosclerosis and Cardiovascular Diseases
- Viral Infections and Immunology Research
- Diabetes Treatment and Management
- Cholesterol and Lipid Metabolism
- Cardiac electrophysiology and arrhythmias
- Aortic Disease and Treatment Approaches
- Cardiac and Coronary Surgery Techniques
Wythenshawe Hospital
2010-2025
Robert Bosch (Germany)
2024
Manchester University
2019-2023
Manchester University NHS Foundation Trust
2016-2022
VA Palo Alto Health Care System
2021
Center for Clinical Research (United States)
2021
Stanford University
2021
University of Manchester
2013-2020
University Foundation
2019
Manchester Academic Health Science Centre
2014-2016
Patients with three-vessel coronary artery disease have been found to better outcomes coronary-artery bypass grafting (CABG) than percutaneous intervention (PCI), but studies in which PCI is guided by measurement of fractional flow reserve (FFR) lacking.
Background — Present therapies for acute coronary syndromes aim toward limiting platelet–platelet adhesion and aggregation processes. However, platelet–leukocyte interactions may contribute importantly to disease progression in the arterial wall. Recent studies suggest that prevention of binding via P-selectin glycoprotein ligand-1 (PSGL-1) be beneficial animal models vascular injury. Methods Results P-selectin–PSGL-1 were found account most platelet–monocyte observed peripheral blood...
Importance In the Revascularization for Ischemic Ventricular Dysfunction (REVIVED-BCIS2) trial, percutaneous coronary intervention (PCI) did not improve outcomes patients with ischemic left ventricular dysfunction. Whether myocardial viability testing had prognostic utility these or identified a subpopulation who may benefit from PCI remained unclear. Objective To determine effect of extent viable and nonviable myocardium on effectiveness PCI, prognosis, improvement in function. Design,...
Previous studies comparing percutaneous coronary intervention (PCI) with artery bypass grafting (CABG) in patients multivessel disease not involving the left main have shown significantly lower rates of death, myocardial infarction (MI), or stroke after CABG. These did routinely use current-generation drug-eluting stents fractional flow reserve (FFR) to guide PCI. FAME 3 (Fractional Flow Reserve versus Angiography for Multivessel Evaluation) is an investigator-initiated, multicenter,...
Complete revascularization of coronary disease has been linked to improved outcomes in patients with preserved left ventricular (LV) function. To identify the impact complete severe LV dysfunction. Patients enrolled REVIVED-BCIS2 trial were eligible if baseline/procedural angiograms and viability studies available for analysis by independent core laboratories. Anatomical viability-guided completeness measured myocardial indices (RIcoro RImyo) respectively, where RIcoro=[change BCIS Jeopardy...
There is evidence that endothelial coverage of drug-eluting stents might be delayed or absent, a risk factor for late thrombotic events. We studied the effects different drug-polymer-device iterations on endothelium-dependent coronary vasomotion. Systemic markers inflammation were correlated with vasomotor changes.Patients paclitaxel-eluting (n=11), sirolimus-eluting (n=21), biolimus A9-eluting (n=28), zotarolimus-eluting (n=10), and bare-metal (n=13) 10, 9, 12 months after implantation,...
Background— Smoking is a potent cardiovascular risk factor and associated with proinflammatory prothrombotic responses. The CD40/CD40 ligand (CD40L) dyad platelet-monocyte aggregation mediate range of processes thought to be important in atherothrombosis. We investigated whether expression the CD40/CD40L are altered cigarette smokers. Methods Results— C-reactive protein (CRP), soluble (s) CD40L, surface CD40L on platelets T cells CD40 monocytes aggregates were compared 25 smokers age-...
Platelet-monocyte aggregates are increasingly being used to quantify platelet activation. The variables that influence platelet-monocyte have not been well defined. We sought determine the effect of blood collection, handling and processing techniques on detected levels using a flow cytometric assay. Whole was labelled with anti-CD14-PE anti-CD42a-FITC. Thereafter, samples were fixed red cells lysed. Analysis performed cytometer initially triggering light scatter then FL-2 identify CD14-PE...
<h3>Objective</h3> The effects of ω-3 fatty acids on endothelial function, fibrinolysis and platelet function are uncertain. We investigated the acid supplementation vasomotor endogenous fibrinolysis, monocyte activation in healthy cigarette smokers; a group at increased risk myocardial infarction. <h3>Design, setting, participants</h3> Twenty smokers were recruited into randomised, double-blind, placebo-controlled, crossover trial supplementation. <h3>Intervention</h3> supplements (2 g/day)...
The purpose of this study was to identify where ultrasmall superparamagnetic particles iron oxide (USPIO) locate in myocardium, develop a methodology that differentiates active macrophage uptake USPIO from passive tissue distribution; and investigate myocardial inflammation cardiovascular diseases. Myocardial is hypothesized be key pathophysiological mechanism heart failure (HF), but human evidence limited, partly because evaluation challenging. USPIO-magnetic resonance imaging (MRI)...
Abstract Background: Intracoronary thermography has been proposed to detect vulnerable plaques. We hypothesized that changes in coronary pressure and flow the coronarytree may interfere with temperature measurements obtained thermistors. Methods Results: First, a very close correlation was found vitro between measured by thermocouple thermistor‐based measuring guide wire (PressureWire, PW) over large range. Second, PW tested low model of “hot plaque”. The sensor could wall 0.5°C as long...
Platelet–monocyte binding and surface P-selectin expression are sensitive markers of platelet activation. Endothelium-derived factors known to inhibit activation may confer important anti-atherothrombotic effects. We assessed the relationship between endothelium-dependent vasomotion in patients with coronary heart disease (CHD). Twenty male stable CHD were compared 20 healthy men. using two-colour flow cytometry on whole blood. Forearm blood was venous occlusion plethysmography during...