A5048615816- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Peripheral Artery Disease Management
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Disease and Treatment Approaches
- Vascular Procedures and Complications
- Cardiac Arrhythmias and Treatments
- Systemic Sclerosis and Related Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Acute Kidney Injury Research
- Coronary Artery Anomalies
- Cardiac pacing and defibrillation studies
- Transplantation: Methods and Outcomes
- Renal and Vascular Pathologies
- Aortic aneurysm repair treatments
- Cancer, Lipids, and Metabolism
Stanford University
2022-2025
Tokyo Women's Medical University
2016-2025
Cardiovascular Institute of the South
2022-2025
Texas A&M University
2024
Tokyo Women's Medical University Hospital
2019-2021
National Hospital Organization
2012-2013
Saiseikai Ibaraki Hospital
2013
Previous studies comparing percutaneous coronary intervention (PCI) with artery bypass grafting (CABG) in patients multivessel disease not involving the left main have shown significantly lower rates of death, myocardial infarction (MI), or stroke after CABG. These did routinely use current-generation drug-eluting stents fractional flow reserve (FFR) to guide PCI. FAME 3 (Fractional Flow Reserve versus Angiography for Multivessel Evaluation) is an investigator-initiated, multicenter,...
Renal impairment is associated with poor clinical outcomes in patients cardiovascular diseases. Some studies have revealed the impact of renal on who underwent mitral valve transcatheter edge-to-edge repair (M-TEER). However, limited data are available regarding baseline after M-TEER Asian-Pacific heart failure and severe regurgitation. This study sought to examine effect using a large-scale nationwide registry Japan. A total 2,150 enrolled OCEAN-Mitral (Optimized Catheter Valvular...
Peak creatine kinase-MB (CK-MB) level is an established predictor of clinical outcomes following acute myocardial infarction (AMI). However, the significance duration between balloon inflation and peak CK-MB (BP time) after primary percutaneous coronary intervention (PCI) remains underexplored in terms prognostic impact. This study aimed to elucidate relationship BP time patients with AMI. In this multicenter observational study, 935 AMI who underwent PCI achieved TIMI flow grade 3 on final...
Coronary pressure indices to assess coronary artery disease are currently underused in patients with aortic stenosis due many potential physiological effects that might hinder their interpretation. Studies varying sample sizes have provided us conflicting results on the effect of transcatheter valve replacement (TAVR) these indices. The aim this meta-analysis was study immediate and long-term TAVR fractional flow reserve (FFR) nonhyperemic ratios (NHPRs).
Rotational atherectomy (RA) is an adjunct tool for the management of heavily calcified coronary lesions during percutaneous intervention (PCI), but long-term clinical outcomes RA use remain unclear in this drug-eluting stent era.Methods and Results:This multi-center registry assessed characteristics patients treated by between 2004 2015. Among 1,090 registered patients, mean age was 70±10 years 815 (75%) were male. Sixty percent had diabetes mellitus 27.7% receiving hemodialysis. The...
BACKGROUND: A functionally significant myocardial bridge (MB) is an important cause of angina with nonobstructive coronary arteries. However, distinguishing a versus incidental MB remains challenging. Resting and hyperemic intracoronary functional indices are available, but no studies have compared their diagnostic performance in MBs. METHODS: We prospectively studied 64 patients arteries, all whom had confirmed by intravascular ultrasound. evaluated the instantaneous wave-free ratio (iFR)...
Importance Outcomes in patients with diabetes after fractional flow reserve (FFR)–guided percutaneous coronary intervention (PCI) using current-generation drug-eluting stents (DES) compared artery bypass grafting (CABG) are unknown. Objectives To investigate the relative treatment effect of PCI vs CABG according to status respect major adverse cardiac and cerebrovascular events (MACCE) at 3 years evaluate impact SYNTAX score. Design, Setting, Participants This is a prespecified subgroup...
We evaluate the prognostic value of measuring fractional flow reserve (FFR) after percutaneous coronary intervention (post-PCI FFR) and intravascular imaging in patients undergoing PCI for 3-vessel artery disease FAME 3 trial (Fractional Flow Reserve versus Angiography Multivessel Evaluation).The is a multicenter, international, randomized study comparing FFR-guided with bypass grafting multivessel disease. was not noninferior respect to primary end point death, myocardial infarction,...
This study investigated whether intensive lipid-lowering therapy with pitavastatin and ezetimibe lowers the incidence of heart failure (HF) events in patients acute coronary syndrome (ACS).
Dynamic intraventricular obstruction after transcatheter aortic valve implantation (TAVI) has been previously reported. There is a risk of haemodynamic collapse in the case left ventricular outflow tract (LVOT) due to systolic anterior motion (SAM) mitral valve.An 83-year-old woman with stenosis (AS) was referred our hospital for TAVI. Transthoracic echocardiography revealed severely calcified peak velocity 6.3 m/s across valve. Acceleration blood flow (peak 2.6 m/s) at LVOT septal bulge...
The instantaneous wave-free ratio (iFR) is an invasive coronary physiological index that not inferior to fractional flow reserve- (FFR-) guided revascularization. indexes of iFR and FFR are similar closely correlated, but there a few key differences. Previous studies suggested patient characteristics lesion severity could induce discordance between FFR. This study aimed clarify the hemodynamics influence FFR.In this retrospective study, we enrolled 225 patients (304 lesions) who underwent...
Reliable assessment of coronary microvascular function is essential. Techniques to measure absolute blood flow are promising but need validation. The objectives this study were: first, validate the potential saline infusion generate maximum hyperemia in vivo. Second, measured with continuous thermodilution at high (40-50 mL/min) speeds and asses its safety.
Using the standard maintenance dose of prasugrel (10 mg/day) as part triple therapy with aspirin and an oral anticoagulant (OAC) is not recommended in current guidelines because it increases risk bleeding compared clopidogrel. However, safety efficacy low-dose (3.75 has been reported.