A5019548316- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- ECG Monitoring and Analysis
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
- Neurological disorders and treatments
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Ion channel regulation and function
- Muscle activation and electromyography studies
- Vascular anomalies and interventions
- Neuroscience and Neural Engineering
- Heart Failure Treatment and Management
- Advanced MRI Techniques and Applications
- Viral Infections and Immunology Research
- Venous Thromboembolism Diagnosis and Management
- Sports injuries and prevention
- Sarcoidosis and Beryllium Toxicity Research
- Infective Endocarditis Diagnosis and Management
Tokyo Women's Medical University
2016-2025
The University of Tokyo
2020-2025
Tokyo Women's Medical University Hospital
2023-2024
Shinshu University
2015-2024
Heart Rhythm Society
2020-2023
Ōtani University
2021
Shinshu University Hospital
2020
Tokyo Medical University Hospital
2018
Henry Ford Hospital
2014
University of Rochester
2013-2014
The implantable cardioverter–defibrillator (ICD) is highly effective in reducing mortality among patients at risk for fatal arrhythmias, but inappropriate ICD activations are frequent, with potential adverse effects.
Background— Ventricular fibrillation is the main mechanism of sudden cardiac death. The feasibility eliminating recurrent episodes by catheter ablation has not been reported. Methods and Results— Twenty-seven patients without known heart disease (13 men, 14 women, 41±14 years age) were studied after being resuscitated from (10±12) primary idiopathic ventricular fibrillation; 23 had received a defibrillator. first initiating beat an identical electrocardiographic morphology coupling interval...
Recently, idiopathic ventricular fibrillation (VF) has gained much attention. Although several subgroups have been described, its pathogenesis, mechanism, treatment, and prognosis remain unknown.We studied six cases of VF with transient late r' waves ST elevation (late r'/ST elevation) in leads V1 through V3. Late was augmented before after episodes. Signal-averaged ECGs showed potentials even when no occurred. During r', a conduction delay observed by use body-surface maps at the anterior...
1 Current status of non‐pharmacotherapies in Japan Pacemaker treatment for bradyarrhythmia was first approved national health insurance coverage Japan 1974, and its use rapidly became widespread thereafter. Approximately 40 years later, 2017, the number patients treated with this technology has increased to 60 137 (41 895 new cases approximately 18 242 replacements). 5 Capsule‐shaped leadless pacemaker also available 2016, is being established as a option. Non‐pharmacological...
Single-chamber ventricular leadless pacemakers do not support atrial pacing or consistent atrioventricular synchrony. A dual-chamber pacemaker system consisting of two devices implanted percutaneously, one in the right atrium and ventricle, would make therapy a treatment option for wider range indications.
The original guideline for non-pharmacological treatments (cardiac implantable electronic device, catheter ablation, and arrhythmia surgery) of arrhythmias (Japanese Circulation Society [JCS] Guideline on Non-pharmacotherapy Cardiac Arrhythmias) was first published in 2001, there have been two revisions thereafter (2006 2011). “JCS Indications Procedures Catheter Ablation” 2012 to cover the rapid development expansion ablation techniques. Advances treatment further accelerated since then,...
1. Stretch‐activated anion currents were studied in sino‐atrial and atrial cells using the whole‐cell patch clamp technique. With continuous application of positive pressure (5‐15 cmH2O) through electrode, cell was inflated membrane conductance increased. 2. Voltage steps revealed that stretch‐activated had time‐independent characteristics. The increase reversible on subsequent negative to electrode. 3. reversal potential shifted by 60 mV for a 10‐fold change intracellular Cl‐ concentration,...
The benefit of novel implantable cardioverter defibrillator (ICD) programming in reducing inappropriate ICD therapy and mortality was demonstrated Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT). However, the cause reduction remains incompletely evaluated. We aimed to identify factors associated with mortality, focus on MADIT-RIT population.In MADIT-RIT, 1500 patients a primary prophylactic indication for or cardiac resynchronization were...
Point-by-point catheter ablation is an established treatment for drug-refractory paroxysmal atrial fibrillation (PAF). However, it time consuming, requires excellent technique to achieve complete pulmonary vein (PV) isolation, and associated with severe complications. The purpose of this study was evaluate the safety effectiveness a HotBalloon (HBA) compared antiarrhythmic drug therapy (ADT) PAF. A prospective multicenter randomized controlled conducted in Japan. Patients symptomatic PAF...
Reduction of left atrial appendage (LAA) flow velocity (FV) is a risk factor for thrombus formation and increases the stroke in patients with fibrillation (AF). Furthermore, LAA morphology correlated AF. The aim this study was to correlate LAAFV We studied 96 (age 59.0 ± 10.2 years, 75% male) referred radiofrequency catheter ablation paroxysmal All underwent computed tomography (CT) transthoracic transoesophageal echocardiography during sinus rhythm. classified as one four types (chicken...
Cardiac physiologic pacing (CPP), encompassing cardiac resynchronization therapy (CRT) and conduction system (CSP), has emerged as a strategy that may mitigate or prevent the development of heart failure (HF) in patients with ventricular dyssynchrony pacing-induced cardiomyopathy. This clinical practice guideline is intended to provide guidance on indications for CRT HF CPP pacemaker HF, patient selection, pre-procedure evaluation preparation, implant procedure management, follow-up...
The first dual-chamber leadless pacemaker (DC-LP) system consists of 2 separate atrial and ventricular devices that communicate to maintain synchronous atrioventricular pacing sensing. initial safety efficacy were previously reported.
BACKGROUND: A dual-chamber leadless pacemaker system has been designed for atrioventricular synchronous pacing using wireless, beat-to-beat, implant-to-implant (i2i) communication between distinct atrial and ventricular pacemakers. The synchrony achieved across various ambulatory scenarios yet to be systematically evaluated. METHODS: prospective, single-arm, unblinded, multicenter, international clinical trial of the was conducted in patients with a conventional indication enrolled from...
BACKGROUND: A dual-chamber leadless pacemaker can provide bradycardia therapy to most patients with indications without the complications associated a lead or pulse generator. We sought confirm whether previously reported 3-month safety and performance outcomes were sustained through 12 months by determining 12-month complication-free success rates exceeded their prespecified goals. METHODS: Patients enrolled in prospective, single-group Aveir DR i2i Study if they had standard indication for...
Anion conductance is known to be activated by mechanical stimulation, such as osmotic cell swelling or inflation via the patch pipette, of canine rabbit cardiac myocytes. The effects stimulation on time-dependent currents, however, remain unsettled. Using whole-cell voltage-clamp method, we have found that stimuli enhance L-type Ca2+ current (ICa,L) in At every membrane potential, ICa,L was reversibly increased and caused applying a positive pressure 10 15 cm H2O pipette. during 37 +/- 21%...
It is unclear whether depression persists in patients with implantable cardioverter defibrillators (ICDs). We evaluated the prevalence and persistence of ICD over a 2-year period.The study included 90 consecutively hospitalized patients. Patients underlying heart disease was 24% coronary artery disease, 29% idiopathic dilated cardiomyopathy, hypertrophic 13% VF/long QT syndrome miscellaneous conditions 11%. A secondary indication for implantation present 20 All completed Zung Self-Rating...