A5006274498- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Ion channel regulation and function
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Viral Infections and Immunology Research
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- ECG Monitoring and Analysis
- Cardiovascular Syncope and Autonomic Disorders
- Neurological Disorders and Treatments
- Coronary Interventions and Diagnostics
- Pericarditis and Cardiac Tamponade
- Neurological disorders and treatments
- Cardiovascular Issues in Pregnancy
- Diabetes Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Pulmonary Hypertension Research and Treatments
Star General Hospital
2020-2025
Tokushima University
1991-2025
Jichi Medical University
2013-2022
Jichi Medical University Hospital
2008-2022
Jichi Medical University Saitama Medical Center
2013-2021
National Cerebral and Cardiovascular Center
2014
Kitasato University
2014
Gunma University
2014
Shiga University of Medical Science
2014
Institute of Cardiology
2009
Postmortem (PM) and µ-calpain-induced degradation of specific skeletal muscle proteins was monitored by SDS-PAGE Western blotting. Samples were removed from bovine longissimus thoracis (LT) at approximately 45 min PM for the preparation at-death (0-d) myofibrils (MF). The LT excised 1 d PM, vacuum-packaged, stored 2ºC. Warner-Bratzler shear force analysis biochemical 1, 3, 7, 14, 28, 56 PM. protease µ-calpain purified used to digest MF pH 5.6, 4ºC, 100 µM CaCl2. Degradation titin, nebulin,...
1 Current status of non‐pharmacotherapies in Japan Pacemaker treatment for bradyarrhythmia was first approved national health insurance coverage Japan 1974, and its use rapidly became widespread thereafter. Approximately 40 years later, 2017, the number patients treated with this technology has increased to 60 137 (41 895 new cases approximately 18 242 replacements). 5 Capsule‐shaped leadless pacemaker also available 2016, is being established as a option. Non‐pharmacological...
The original guideline for non-pharmacological treatments (cardiac implantable electronic device, catheter ablation, and arrhythmia surgery) of arrhythmias (Japanese Circulation Society [JCS] Guideline on Non-pharmacotherapy Cardiac Arrhythmias) was first published in 2001, there have been two revisions thereafter (2006 2011). “JCS Indications Procedures Catheter Ablation” 2012 to cover the rapid development expansion ablation techniques. Advances treatment further accelerated since then,...
We examined the effects of 1,25-dihydroxyvitamin D3(1,25-(OH)2D3) on proliferation vascular smooth muscle (VSM) cells. Receptors for 1,25-(OH)2D3 were demonstrated in fresh rabbit aortic tissue and cultured rat VSM using binding [3H]-1,25-(OH)2D3 sucrose density gradients or cell homogenates. The receptor sedimented at 3.6 S, sedimentation velocity receptors from other sources. dramatically altered growth VSM, but this effect depended importantly basal conditions which cells grown. In...
Background— Electrical storms (ESs) in patients with Brugada syndrome (BrS) are rare though potentially lethal. Methods and Results— We studied 22 men BrS ES, defined as ≥3 episodes/d of ventricular fibrillation (VF) compared their characteristics those 110 age-matched, control without ES. was diagnosed by a spontaneous or drug-induced type 1 pattern on the ECG absence structural heart disease. Early repolarization (ER) J waves, ie, >0.1 mV notches slurs terminal portion QRS complex. The...
Abstract To investigate the relationships among diurnal blood pressure (BP) variations and autonomic nervous system dysfunction, we assessed heart rate variability (HRV) using power spectral analysis of 24-hour RR interval in 51 asymptomatic elderly hypertensive patients with various patterns nocturnal BP fall. The extreme-dippers marked fall (n=16) had lower asleep low-frequency (LF)/high-frequency (HF) ratios (a relative index sympathetic activity), while nondippers without (n=18) awake...
In order to analyze the complex activities of histamine H2 receptor activation on neutrophils, human HL-60 promyelocytic leukemia cells were differentiated into neutrophils by incubation with dimethyl sufoxide, loaded Ca2+-sensitive indicator dyes, indo-1 or fura-2, and levels intracellular Ca2+ ([Ca2+]i) measured in a fluorescent-activated cell sorter fluorimeter, respectively. Histamine increased [Ca2+]i dose-dependent manner half-maximal concentration (EC50) approximately 10−6 10−5 M,...
Purified myofibril (MF) and homogenized whole muscle (WM) samples were prepared from A maturity market steers. Samples removed at 0, 1, 3, 7, 14, 28 d postmortem. The MF WM all steers analyzed by SDS-PAGE (5% gels) Western blot analysis using monoclonal antibodies to titin nebulin. rates of degradation the intact forms nebulin, with regard differences dependent on sample type (MF vs WM), examined. results showed that there was very little difference in rate postmortem form or nebulin respect...
Peripheral venoarterial extracorporeal membranous oxygenation (ECMO) support is effective in patients with cardiogenic shock or fatal arrhythmia due to fulminant myocarditis. The clinical courses of myocarditis are still uncertain; therefore, it difficult determine the appropriate time for discontinuing ECMO converting a ventricular assist device. purpose this study was investigate prognosis managed by ECMO. Twenty-two consecutive peripheral between 1999 and 2013 were enrolled. Survival...
Endothelin is a potent mammalian vasoconstrictive peptide with structural homology to cation channel-binding insect toxins. We tested the proposal that this directly activates dihydropyridine-sensitive Ca2+ channels in cultured vascular smooth muscle (VSM) cells. First, we found cell can be altered VSM by activation of voltage-operated channels. KCl-induced depolarization and dihydropyridine channel agonist (-) Bay K 8644 (10 microM) both raised more than twofold; effect KCl was blocked...
Abstract The role for intracellular Ca2+ in modulating activity of the Na+/H+ exchanger was studied cultured vascular smooth muscle cells. exchange activated by four distinct stimuli: 1) phorbol 12-myristate 13-acetate, 2) thrombin, 3) cell shrinkage, and 4) acid loading. [Ca2+]i independently varied between 40 200 nM varying bathing from 10 to 5.0 mM. Thrombin-induced transients were blocked with bis(2-amino-5-methylphenoxy)ethane-N,N,N',N'-tetraacetic tetraacetoxymethyl ester (MAPTAM). In...
Hospitalizations are common in patients with heart failure and associated high mortality, readmission economic burden. Detecting early signs of worsening may enable earlier intervention reduce hospitalizations. The HeartLogic algorithm is designed to predict using diagnostic data from multiple device sensors. main objective this analysis was evaluate the sensitivity alert calculation predicting events (HFEs). We also evaluated false positive rate (FPR) compared incidence HFEs occurring a...
Abstract Objectives Recently, various endoscopic treatments for colorectal polyps have been reported, including cold snare polypectomy (CSP) and underwater mucosal resection (UEMR), in addition to EMR. However, a precise treatment strategy sessile serrated lesions (SSL) has not established. In this study, we analyzed the clinicopathological features of SSL resected by EMR, CSP, UEMR determine most suitable SSL. Methods A total 92 via EMR ( n = 11), CSP 36), 45) were retrospectively enrolled...
Abstract Background Accurate prediction for survival in individualized patients with cardiac resynchronization therapy a defibrillator (CRT‐D) is difficult. Methods We analyzed the New Japan device treatment registry (JCDTR) database to develop model CRT‐D recipients. Results Four hundred and eighty‐two recipients, at implantation year 2018–2021, QRS width ≥120 ms left ventricular ejection fraction (LVEF) ≤35% baseline, were analyzed. During an average follow‐up of 21 ± 10 months, death...
Abstract Background Evidence supporting the benefit from primary prevention implantable cardioverter‐defibrillator (ICD)/cardiac resynchronization therapy with a defibrillator (CRT‐D) for heart failure reduced ejection fraction (HFrEF) is scarce in real‐world settings. Methods We analyzed propensity score matched cohorts of patients eligible Sudden Cardiac Death Heart Failure Trial (SCD‐HeFT) Japan cardiac device treatment registry (JCDTR) and Japanese Registry Cardiology (JCARE‐CARD). The...
Abnormal patterns of diurnal blood pressure (BP) variation have been reported to be related advanced target organ damage and poor cardiovascular prognosis. However, the neurohumoral characteristics patients with such not fully investigated. We measured BP plasma levels factors (norepinephrine [NE], epinephrine, renin, arginine vasopressin [VP]) during 70° head-up tilt test (10 min supine 15 tilting) in 120 older subjects (mean age 71 years) who had sustained hypertension as determined by...
Abstract Aims The HINODE study aimed to analyse rates of mortality, appropriately treated ventricular arrhythmias (VA), and heart failure in Japanese patients compared with those Western patients. Methods results After treatment decisions following contemporary practice Japan, were prospectively enrolled into four cohorts: (i) internal cardioverter‐defibrillator (ICD), (ii) cardiac resynchronization therapy (CRT) defibrillator (CRT‐D), (iii) standard medical (‘non‐device’: ND), or (iv)...