A5052964243- Cardiac electrophysiology and arrhythmias
- Hearing Loss and Rehabilitation
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Cardiac Valve Diseases and Treatments
- Heart Rate Variability and Autonomic Control
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Ischemia and Reperfusion
- Acute Myocardial Infarction Research
- Noise Effects and Management
- Hearing, Cochlea, Tinnitus, Genetics
- Cardiovascular Effects of Exercise
- Ion channel regulation and function
- Cardiomyopathy and Myosin Studies
- Atrial Fibrillation Management and Outcomes
- Multisensory perception and integration
- Nitric Oxide and Endothelin Effects
- Heart Failure Treatment and Management
- Receptor Mechanisms and Signaling
- Congenital Heart Disease Studies
- Cardiac Fibrosis and Remodeling
Uniformed Services University of the Health Sciences
2014-2025
Henry M. Jackson Foundation
2024-2025
Walter Reed National Military Medical Center
1984-2024
Jackson Foundation
2024
University of Rochester
1999-2018
National Heart Lung and Blood Institute
1974-2015
University of Virginia
2015
Henry Ford Hospital
2014
Hebrew University of Jerusalem
1999-2011
Case Western Reserve University
2011
The Multicenter Diltiazem Postinfarction Trial (MDPIT) reported no consistent diltiazem effect on new or worsened congestive heart failure (CHF) during 12-52 months' follow-up after acute myocardial infarction. This was puzzling in light of the observation that patients with findings suggesting left ventricular dysfunction (LVD) at baseline had more cardiac events (cardiac mortality recurrent nonfatal infarction) than such placebo. We hypothesized increased frequency late CHF as well events,...
ABSTRACT The endogenous eyeblink is identified as a cortically controlled response event, distinguishable from both reflexive and voluntary lid movements. It has characteristic rate, form, temporal distribution. These aspects of blinks are related to cognitive state variables. Allocation attentional resources, transition points in information processing flow, possibly mode, indexed by blink parameters.
The mammalian AML/CBFalpha runt domain (RD) transcription factors regulate hematopoiesis and osteoblast differentiation. Like their Drosophila counterparts, most RD proteins terminate in a common pentapeptide, VWRPY, which serves to recruit the corepressor Groucho (Gro). Using yeast two-hybrid assay, vitro association pull-down experiments, we demonstrate that Gro its homolog TLE1 specifically interact with AML1 AML2. In addition VWRPY motif, other C-terminal sequences are required for these...
This investigation was undertaken in normal subjects to define the relationship between intensity of exercise and magnitude fibrinolytic response examine effect diurnal variations on response. Fibrinolytic activity measured fibrin plates expressed as mm 2 . Diurnal occurred with lowest at 8:00 AM (mean, 66 ), peak 5:00 PM 266 , P <0.001). Five minutes maximal treadmill caused a marked increase mean from 90 658 ( 70% produced no significant increase, but 30 increased 626 <0.005). In...
Background —Thrombosis is a pivotal event in the pathogenesis of coronary disease. We hypothesized that presence blood factors reflect enhanced thrombogenic activity would be associated with an increased risk recurrent events during long-term follow-up patients who have recovered from myocardial infarction. Methods and Results —We prospectively enrolled 1045 2 months after index Baseline tests included 6 hemostatic variables ( d -dimer, fibrinogen, factor VII, VIIa, von Willebrand factor,...
The severity of angina and the effects therapeutic interventions in patients with coronary artery disease have been assessed by determining changes both exercise performance triple product (TP) heart rate, systolic pressure, ejection time occurring at angina. However, validity conclusions based on such is uncertain since different protocols these variables not determined. Twelve were studied during upright bicycle exercise; repeated bouts using a standard protocol 20-w increments every three...
It is commonly believed that vagally-mediated bradycardia predisposes to ventricular fibrillation (VF) during acute myocardial ischemia. Recent experimental studies, however, have shown and vagal stimulation independently raise the threshold for electrically induced VF in ischemic canine heart. To determine influence of on spontaneous development occurring ischemia, open-chest dogs with coronary occlusion were observed without electrical stimulation. When heart rate was allowed fall, mean...
Patients with cardiac disorders have defective parasympathetic control of heart rate. To evaluate the possibility similar changes in sympathetic rate, we compared reflex chronotropic responses to 80 degree upright tilt and nitroglycerin-induced hypotension 31 patients 7 normal individuals before after partial blockade atropine. Tilting revealed an attenuation rate increase patients; magnitude this defect was greatest more severe symptoms (class III) evidence left ventricular dysfunction (the...
To elucidate the direct influence of nitroglycerin on coronary collateral function in patients and to clarify relation between angiographic appearance functional performance collaterals, we measured retrograde flow peripheral pressure (PCP) before after undergoing saphenous vein bypass. Measurements were made via distally (but not proximally) attached graft while artery receiving was totally occluded proximal site attachment. Nitroglycerin (100 150 mcg bolus 100 mcg/min) infused into...
Cutaneous absorption of nitroglycerin is a well-documented phenomenon which may have unique advantages for the sustained prophylaxis angina pectoris. Therefore, we examined effects ointment and placebo on exercise capacity in 14 patients with Nitroglycerin produced significant increase persisted at least three hours. Concomitant changes systolic blood pressure resting heart rate were observed. Electrocardiographic evidence myocardial ischemia was significantly reduced. Chronic administration...
In order to resolve current controversies on isosorbide dinitrate (ISDN), we employed a particularly sensitive testing protocol evaluate effects of sublingual ISDN and nitroglycerin the exercise capacity patients with angina. Ten minutes after 21 23 exercised longer (average 2.7 minutes, P < 0.001) than placebo. Benefit was evident in only minority tested one hour none two hours either or nitroglycerin. A given amount resulted lower mean blood pressure 13 mm Hg, 0.001), higher heart rate...
Central and occipital EEG alpha were used as an on -line measure of momentary changes in covert attention during television viewing. Alpha was recorded nine 30-second commercials shown embedded a half-hour situation comedy. Two time series constructed for data analysis. A stimulus consisted codes representing the presence or absence scene person object movement each half-second interval commercials. The median scores interval, aggregated across 26 subjects. regressed change series, both...
Although pectus excavatum is thought to impair cardiac performance, no consistent hemodynamic abnormalities have been identified. We hypothesized that function might be impaired during upright exercise when the heart descends into deformity. Catheterization of right side in six patients with gave normal results, and response supine was normal. In contrast, output (CO) intense low two patients, at lower limits one, two. The CO stroke-volume responses mild also differed from After operative...
ARRHYTHMIAS and cardiac failure are two of the major, potentially lethal sequelae acute myocardial infarction. Although measures used to treat arrhythmias usually considered separately from those failure, it is clear that share a common precipitating mechanism —severe ischemic injury (as defined by reduction in oxygen delivery cell resulting initially aberrations biochemical, electrophysiologic mechanical function and, if unrelieved, ultimately death). Moreover, some cases infarction...
There are no data regarding the differential response to cardiac resynchronization therapy with defibrillator (CRT-D) by aetiology of cardiomyopathy in mildly symptomatic patients. We evaluated outcome patients enrolled MADIT-CRT ischaemic and non-ischaemic (ICM non-ICM, respectively). The clinical CRT-D was assessed among ICM (n = 1046) non-ICM 774) during an average follow-up 2.4 years, echocardiographic at 1 year. Cardiac vs. ICD associated respective 34% (P 0.001) 44% 0.002) reductions...
To investigate the possibility that a genetically transmitted cardiac abnormality is involved in genesis of sudden infant death syndrome (SIDS), 42 sets parents who had at least one with SIDS were studied by electrocardiography. Prolongation QT interval was present member 11 (26%) parents. In families which prolongation found parent, prolonged also 39% siblings infants SIDS, suggesting an autosomal dominant pattern inheritance. addition, "near-miss" showed marked interval. Thus, our data...
The benefit of novel implantable cardioverter defibrillator (ICD) programming in reducing inappropriate ICD therapy and mortality was demonstrated Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT). However, the cause reduction remains incompletely evaluated. We aimed to identify factors associated with mortality, focus on MADIT-RIT population.In MADIT-RIT, 1500 patients a primary prophylactic indication for or cardiac resynchronization were...
The physiologic basis for the frequent complaint of worsening symptoms in a cold environment was investigated six patients with and five without coronary-artery disease, at rest during identical levels mild upright exercise 25 15°C, similar results. Significantly higher lower temperature were mean systemic arterial pressure (105 vs 92 mm mercury 110 exercise; p less than 0.001), total peripheral resistance (1821 1609 dynes-sec-cm-5 rest, 1213 993 0.02) left ventricular minute work (6.5 5.7...
The effects of treatment with nitroglycerin (TNG) and methoxamine on the degree ischemic injury occurring during 5 hours coronary occlusion were studied in 31 closed-chest sedated dogs. Acute was produced by inflating a cuff previously implanted around left anterior descending artery. After 10 min ischemia (assessed intramyocardial electrodes), dogs randomized into control treated groups. Treated received i.v. TNG remainder hour occlusion. Arterial pressure maintained at preinfusion levels...
Averaged evoked responses to clicks were elicited from 20 normal-hearing subjects between the ages of 16 and 41. Two thousand presented right ear at rate 10 per sec 60, 30, 10, 5, 0, −5, −10 dB SL. Sensation levels varied randomly. In each series two control conditions without stimulation randomly interspersed. Electroencephalic potentials recorded an electrode on vertex skull referred left earlobe. The response pattern was relatively consistent with a vertex-negative peak (N ) about 20–24...