Roby Rakhit
A5091491956- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Cardiovascular Disease and Adiposity
- Cardiac Structural Anomalies and Repair
- Cardiac Ischemia and Reperfusion
- Advanced MRI Techniques and Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- HIV-related health complications and treatments
- Photoacoustic and Ultrasonic Imaging
- Cerebrovascular and Carotid Artery Diseases
- Optical Coherence Tomography Applications
- Nitric Oxide and Endothelin Effects
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiomyopathy and Myosin Studies
- Cardiovascular Health and Disease Prevention
- Vascular Procedures and Complications
- Health Systems, Economic Evaluations, Quality of Life
- Venous Thromboembolism Diagnosis and Management
- Lipoproteins and Cardiovascular Health
- Aortic aneurysm repair treatments
- Mechanical Circulatory Support Devices
- Amyloidosis: Diagnosis, Treatment, Outcomes
Royal Free London NHS Foundation Trust
2016-2025
The Royal Free Hospital
2015-2024
University College London
2015-2024
University Hospital Galway
2023
Engineering and Physical Sciences Research Council
2020
Wellcome / EPSRC Centre for Interventional and Surgical Sciences
2019
The Wellington Hospital
2017
Centro Cardiologico Monzino
2017
Imperial College Healthcare NHS Trust
2014-2015
Hammersmith Hospital
1993-2015
BackgroundRemote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown reduce myocardial infarct size in patients ST-elevation infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote could incidence of cardiac death hospitalisation for heart failure at 12 months.MethodsWe did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) 33...
BackgroundThe International Liaison Committee on Resuscitation has called for a randomised trial of delivery to cardiac arrest centre. We aimed assess whether expedited centre compared with current standard care following resuscitated reduces deaths.MethodsARREST is prospective, parallel, multicentre, open-label, superiority trial. Patients (aged ≥18 years) return spontaneous circulation out-of-hospital without ST elevation were randomly assigned (1:1) at the scene their by London Ambulance...
Background: Cardiogenic shock remains a major cause of morbidity and mortality in patients with ST-segment elevation myocardial infarction. We aimed to assess the current trends cardiogenic management, looking specifically at incidence, use intra-aortic balloon pump therapy outcomes infarction treated primary percutaneous coronary intervention. Methods results: undertook an observational cohort study 21,210 between 2005–2015 eight Heart Attack Centres London, UK. Patients’ details were...
Clinical trials suggest that intracoronary delivery of autologous bone marrow-derived cells (BMCs) 1–7 days post-acute myocardial infarction (AMI) may improve left ventricular (LV) function. Earlier time points have not been evaluated. We sought to determine the effect BMC on LV function when delivered within 24 h successful reperfusion therapy. A multi-centre phase II randomized, double-blind, and placebo-controlled trial. One hundred patients with anterior AMI significant regional wall...
Objectives To understand the impact of COVID-19 on delivery and outcomes primary percutaneous coronary intervention (PPCI). Furthermore, to compare clinical presentation patients with ST-segment elevation myocardial infarction (STEMI) active against those without COVID-19. Methods We systematically analysed 348 STEMI cases presenting PPCI programme in London during peak pandemic (1 March 30 April 2020) compared 440 from same period 2019. Outcomes interest included ambulance response times,...
Importance In the Revascularization for Ischemic Ventricular Dysfunction (REVIVED-BCIS2) trial, percutaneous coronary intervention (PCI) did not improve outcomes patients with ischemic left ventricular dysfunction. Whether myocardial viability testing had prognostic utility these or identified a subpopulation who may benefit from PCI remained unclear. Objective To determine effect of extent viable and nonviable myocardium on effectiveness PCI, prognosis, improvement in function. Design,...
Cardiac involvement is the main driver of clinical outcomes in systemic amyloidosis and preliminary studies support hypothesis that myocardial ischaemia contributes to cellular damage. The aims this study were assess presence mechanisms using cardiovascular magnetic resonance (CMR) with multiparametric mapping histopathological assessment.
Complete revascularization of coronary disease has been linked to improved outcomes in patients with preserved left ventricular (LV) function. To identify the impact complete severe LV dysfunction. Patients enrolled REVIVED-BCIS2 trial were eligible if baseline/procedural angiograms and viability studies available for analysis by independent core laboratories. Anatomical viability-guided completeness measured myocardial indices (RIcoro RImyo) respectively, where RIcoro=[change BCIS Jeopardy...
Background —As shown previously, exposure to NO donors initiates protective mechanisms in cardiomyocytes that persist after removal of the donor, a form pharmacological preconditioning. Because also affects mitochondrial respiration, we studied effect on Ca 2+ uptake. Methods and Results —Neonatal rat ventricular myocytes primary culture were exposed 1 hour simulated ischemia reoxygenation (sI/R). Pretreatment with donor S -nitroso- N -acetyl-penicillamine (SNAP) (1 mmol/L for 90 minutes),...
To test associations between heart rate variability (HRV), depressed mood, and positive affect in patients with suspected coronary artery disease (CAD). Depression is associated impaired HRV post acute cardiac events, but evidence stable (CAD) inconsistent.Seventy-six (52 men, 24 women; mean age = 61.1 years) being investigated for CAD on the basis of symptomatology noninvasive tests, completed 24-hour electrocardiograms. The Beck Inventory (BDI) was administered, measured over study period...
Microvascular angina is caused by cardiac small vessel disease, and dysregulation of the endothelin system implicated. The minor G allele non-coding single nucleotide polymorphism (SNP) rs9349379 enhances expression 1 gene in human vascular cells, increasing circulating concentrations ET-1. prevalence this higher patients with ischemic heart disease. Zibotentan a potent, selective inhibitor ET
Abstract Miniaturised high-resolution imaging devices are valuable for guiding minimally invasive procedures such as vascular stent placements. Here, we present all-optical rotational B-mode pulse-echo ultrasound imaging. With this device, transmission and reception performed with light. The transducer in the probe comprised an optical fibre that delivered pulsed excitation light to head at distal end a multi-walled carbon nanotube polydimethylsiloxane composite coating. This coating was...
To investigate percutaneous coronary intervention (PCI) practice in an international cohort of patients with spontaneous artery dissection (SCAD). explore factors associated complications and study angiographic longer term outcomes.SCAD (n=215, 94% female) who underwent PCI from three national studies were investigated compared a matched conservatively managed SCAD (n=221).SCAD-PCI high risk at presentation only 8.8% undergoing outside the context ST-elevation myocardial infarction/cardiac...
Background: Microvascular angina is associated with dysregulation of the endothelin system and impairments in myocardial blood flow, exercise capacity, health-related quality life. The G allele noncoding single nucleotide polymorphism RS9349379 enhances expression endothelin-1 gene ( EDN1 ) human vascular cells, potentially increasing circulating concentrations Endothelin-1 (ET-1). Whether zibotentan, an oral ET-A receptor selective antagonist, efficacious safe for treatment microvascular...
To report the extent and distribution of myocardial injury its impact on left ventricular systolic function with cardiac magnetic resonance imaging (CMR) following spontaneous coronary artery dissection (SCAD) to investigate predictors injury.One hundred fifty-eight angiographically confirmed SCAD-survivors (98% female) were phenotyped by CMR compared in a case-control study 59 (97% healthy controls (44.5 ± 8.4 vs. 45.0 9.1 years). Spontaneous presentation was non-ST-elevation infarction 95...
The aim of this study was to investigate the role nitric oxide (NO) in a cellular model early preconditioning (PC) cultured neonatal rat ventricular myocytes. Cardiomyocytes "preconditioned" with 90 min stimulated ischemia (SI) followed by 30 reoxygenation normal culture conditions were protected against subsequent 6 h SI. PC blocked N(G)-monomethyl-L-arginine monoacetate but not dexamethasone pretreatment. Inducible synthase (NOS) protein expression detected during ischemia. Pretreatment...