A5062168421- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Cardiac Ischemia and Reperfusion
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Cardiac and Coronary Surgery Techniques
- Cardiac Structural Anomalies and Repair
- Tissue Engineering and Regenerative Medicine
- Health Systems, Economic Evaluations, Quality of Life
- Pluripotent Stem Cells Research
- Vascular Procedures and Complications
- COVID-19 and healthcare impacts
- Peripheral Artery Disease Management
- Heart Failure Treatment and Management
- Cerebrovascular and Carotid Artery Diseases
- Atrial Fibrillation Management and Outcomes
- Mesenchymal stem cell research
- Aortic aneurysm repair treatments
- Cardiovascular Function and Risk Factors
- Acute Kidney Injury Research
William Harvey Research Institute
2016-2025
Barts Health NHS Trust
2016-2025
Queen Mary University of London
2016-2025
St Bartholomew's Hospital
2015-2024
British Heart Foundation
2017-2024
National Health Service
2013-2024
University of Leeds
2024
Behavioral Health of the Palm Beaches
2023
National Institute for Health Research
2013-2021
Sonoma State University
2020
BACKGROUND: In patients with acute myocardial infarction (MI), therapies that could further reduce the risk of adverse cardiovascular and metabolic outcomes are needed. METHODS: this international registry-based, randomized, double-blind trial, without prior diabetes or chronic heart failure, presenting MI impaired left ventricular systolic function, were randomly assigned 10 mg dapagliflozin placebo, given once daily. The primary outcome was hierarchical composite death, hospitalization for...
Contrast-induced nephropathy (CIN), also known as contrast-associated acute kidney injury (CA-AKI) underlies a significant proportion of the morbidity and mortality following coronary angiographic procedures in high-risk patients remains unmet need. In pre-clinical studies inorganic nitrate, which is chemically reduced vivo to nitric oxide, renoprotective but this observation yet be translated clinically. study, efficacy nitrate prevention CIN presenting with syndromes (ACS) reported.
To evaluate rehabilitation after myocardial infarction.Randomised controlled trial of in unselected infarction patients six centres, baseline data being collected on admission and by structured interview (of spouses) shortly discharge outcome assessed at months clinical examination 12 months.Six district general hospitals.All 2328 eligible admitted over two years with confirmed discharged home within 28 days.Rehabilitation programmes comprising psychological therapy, counselling, relaxation...
Health visitors were employed specifically to care for two years a random sample of patients in general practice who aged over 70. Independent assessments made at the beginning and end study showed that health visitor an urban had some impact on her caseload patients; she provided more services them, their mortality was reduced, quality life improved, though last measure just failed be statistically significant. The working rural no such effect.
Abstract A series of 178 patients in whom carcinoma the breast was associated with pregnancy has been analysed. In 121 diagnosed during (CP group) and 57 occurred subsequent to definitive treatment for primary (SP group). Patients presented more advanced disease CP group, 72 per cent being axillary node positive. Only 37 survived 5 years, although 79 negative years. Survival not affected by age, nor phase which or treated. The majority pregnancies (79 cent) ended delivery a normal child....
BackgroundFor late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) assessment of atrial scar to guide management and targeting ablation in fibrillation (AF), an objective, reproducible method identifying is required.ObjectiveTo describe automated for operator-independent quantification LGE that correlates with colocated endocardial voltage clinical outcomes.MethodsLGE CMR imaging was performed at 2 centers, before 3 months after pulmonary vein isolation paroxysmal AF (n...
Background: Cardiogenic shock remains a major cause of morbidity and mortality in patients with ST-segment elevation myocardial infarction. We aimed to assess the current trends cardiogenic management, looking specifically at incidence, use intra-aortic balloon pump therapy outcomes infarction treated primary percutaneous coronary intervention. Methods results: undertook an observational cohort study 21,210 between 2005–2015 eight Heart Attack Centres London, UK. Patients’ details were...
Current guidelines recommend the use of vitamin K antagonist (VKA) for up to 3-6 months treatment left ventricular (LV) thrombus post-acute myocardial infarction (AMI). However, based on evidence supporting non-inferiority novel oral anticoagulants (NOAC) compared VKA other indications such as deep vein thrombosis, pulmonary embolism (PE), and thromboembolic prevention in atrial fibrillation, NOACs are being increasingly used off licence LV post-AMI. In this study, we investigated safety...
Rationale: Preclinical evidence demonstrates that inorganic nitrite, after its in situ conversion to nitric oxide, attenuates consequent myocardial reperfusion injury. Objective: We investigated whether intracoronary injection of nitrite during primary percutaneous coronary intervention might improve infarct size ST-elevated infarction. Methods and Results: Patients undergoing (n=80) were randomized receive (10 mL) sodium (1.8 μmol) or NaCl (placebo) before balloon inflation. The end point...
Clinical trials suggest that intracoronary delivery of autologous bone marrow-derived cells (BMCs) 1–7 days post-acute myocardial infarction (AMI) may improve left ventricular (LV) function. Earlier time points have not been evaluated. We sought to determine the effect BMC on LV function when delivered within 24 h successful reperfusion therapy. A multi-centre phase II randomized, double-blind, and placebo-controlled trial. One hundred patients with anterior AMI significant regional wall...
BACKGROUND: Patients with previous coronary artery bypass grafting often require invasive angiography (ICA). However, for these patients, the procedure is technically more challenging and has a higher risk of complications. Observational studies suggest that computed tomography cardiac (CTCA) may facilitate ICA in this group, but not been tested randomized controlled trial. METHODS: This study was single-center, open-label trial assessing benefit adjunctive CTCA patients referred ICA. were...
The REGENERATE-DCM trial is the first phase II randomized, placebo-controlled aiming to assess if granulocyte colony-stimulating factor (G-CSF) administration with or without adjunctive intracoronary (IC) delivery of autologous bone marrow-derived cells (BMCs) improves global left ventricular (LV) function in patients dilated cardiomyopathy (DCM) and significant cardiac dysfunction.Sixty DCM ejection fraction (LVEF) at referral ≤45%, New York Heart Association (NYHA) classification ≥2 no...
Aims: to determine the ownership and use of various assistive devices by older people living at home.
A random sample of patients aged 70 and over from a general practice were interviewed in their own homes. Information was sought on hearing difficulty mental state: standardised measures anxiety, depression, memory loss used. Of the 657 subjects interviewed, 33% reported having normal conversations 6% experiencing "much difficulty." Hearing associated with both depression but associations weakened when adjustment made for physical disability. The association disappeared adjusted There close...
Solutions are derived for mode I and II stress intensity factors a crack at the edge of sheet subjected to localized fretting forces. Both normal tangential forces considered. These solutions approximated by polynomial function length, which is then used as Green's derive arbitrary distributions tensile shear stresses sheet.
<h3>Aim</h3> Primary percutaneous coronary intervention (PPCI) produces more effective reperfusion and allows immediate risk stratification compared with fibrinolysis. We investigated the safety feasibility of very early discharge at 2 days following PPCI in selected low-risk cases. <h3>Methods</h3> This was a prospective observational cohort study 2779 patients who underwent between 2004 2011. Patients meeting criteria were deemed suitable for discharge; TIMI III flow, left ventricle (LF)...