A5067244524- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Aortic Disease and Treatment Approaches
- Cardiac Fibrosis and Remodeling
- Atrial Fibrillation Management and Outcomes
- Vascular Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Cardiovascular Function and Risk Factors
- Venous Thromboembolism Diagnosis and Management
- Mechanical Circulatory Support Devices
- COVID-19 and Mental Health
- Healthcare professionals’ stress and burnout
- Cardiac tumors and thrombi
- COVID-19 and healthcare impacts
- Cardiac Ischemia and Reperfusion
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Issues in Pregnancy
- Mesenchymal stem cell research
University of Liverpool
2020-2021
Blackpool Victoria Hospital
2020-2021
Le Moyne College
2021
Wildlife Information Liaison Development
2021
Blackpool Teaching Hospitals NHS Foundation Trust
2017-2020
London Health Sciences Centre
2017-2020
Western University
2017-2019
Barts Health NHS Trust
2011-2018
St Bartholomew's Hospital
2015-2018
Manchester Royal Infirmary
2013-2017
The REGENERATE-DCM trial is the first phase II randomized, placebo-controlled aiming to assess if granulocyte colony-stimulating factor (G-CSF) administration with or without adjunctive intracoronary (IC) delivery of autologous bone marrow-derived cells (BMCs) improves global left ventricular (LV) function in patients dilated cardiomyopathy (DCM) and significant cardiac dysfunction.Sixty DCM ejection fraction (LVEF) at referral ≤45%, New York Heart Association (NYHA) classification ≥2 no...
Readers are invited to submit letters for publication in this department. Submit online at ht∗∗tp://joem.edmgr.com. Choose "Submit New Manuscript." A signed copyright assignment and financial disclosure form must be submitted with the letter. Form available www.joem.org under Author Reviewer information. To Editor: The United Kingdom's National Health Service (NHS), along other health services around world, faces unprecedented pressures dealing COVID-19 pandemic.1 stress on NHS is not...
<h3>Abstract</h3> ST segment elevation myocardial infarction remains a significant contributor to morbidity and mortality worldwide, despite declining incidence better survival rates. It usually results from thrombotic occlusion of coronary artery at the site ruptured or eroded plaque. Diagnosis is based on characteristic symptoms electrocardiogram changes, confirmed subsequently by raised cardiac enzymes. Prognosis dependent size infarct, presence collaterals speed with which occluded...
Abstract Aims The effect of combined cytokine and cell therapy in ischaemic cardiomyopathy is unknown. Meta‐analyses suggest improved cardiac function with therapy. optimal delivery route remains unclear. We investigated whether granulocyte colony‐stimulating factor (G‐ CSF ) alone or combination intracoronary (i.c.) intramyocardial (i.m.) injection autologous bone marrow‐derived cells ( BMCs improves function. Methods results Ninety patients symptomatic no further treatment options were...
This study analyses the attitudes of patients towards presence medical students during consultations. It was conducted in a very culturally and ethnically diverse part London. The aimed to investigate factors, particularly ethnicity, which influence patients' students. A total 422 participated study, general practice hospital outpatient waiting areas London Boroughs Tower Hamlets Hackney. In general, results demonstrate that are positive student participation particular, older patients, born...
Bone marrow stem cell (BMSC) therapy for cardiovascular disease has shown considerable preclinical and clinical promise, but there remains a need mechanistic studies to help bridge the transition from bench bedside. We have designed substudy our REGENERATE-IHD trial (ClinicalTrial.gov Identifier: NCT00747708) assess feasibility of novel imaging technique detect angiogenesis following BMSC therapy.Nine patients who had been randomized receive intracoronary injection G-CSF-mobilized BMSCs or...
To ascertain the level of psychological distress, using validated psychology tools, among British National healthcare workers (HCW) during first wave Covid-19 crisis.A multi-centre, anonymized, all-comer staff survey across 3 hospitals in Lancashire, England (April to June 2020), consisting Patient Health Questionnaire (PHQ-9), Perceived Stress Scale-10 (PSS-10), Generalized Anxiety Disorder-7 (GAD-7), and Impact Events Scale (IES-6).Among 1113 HCW, median (IQR) PHQ-9, GAD-7, PSS-10, IES-6...
Background Transcatheter aortic valve implantation (TAVI) is associated with periprocedural and postprocedural morbidity mortality. Currently, there a paucity of risk stratification models for potential TAVI candidates. We employed the CHA 2 DS -Vasc score to quantify 30-day mortality in patients undergoing TAVI. Methods results A retrospective analysis registry data consecutive at 3 tertiary centres Northwest England between 2008 2013. The its modification—the R score, which includes...
A 45-year-old previously healthy man with minimal coronary artery disease on imaging presented an acute MI after sustaining a wasp sting following previous non-eventful exposures throughout his life. This is the first case of Kounis syndrome optical coherence tomography and proven IgE venom hypersensitivity. The Hymenoptera composed allergenic proteins vasoactive amines which are responsible for toxicity. patient also has history atopy giving predisposition developing IgE-mediated allergic...
Abdelaziz, Hesham K. MD, PhD; Patel, Billal Chalil, Shajil FRCP; Choudhury, Tawfiq MRCP Author Information
Aims: Despite the widespread use of radial approach in coronary interventions, left ventricular endomyocardial biopsy (LV-EMB) is most frequently performed via femoral artery. We sought to assess feasibility and safety compared access a large cohort patients undergoing LV-EMB. Methods results: Data from 264 who underwent LV-EMB Germany, Portugal, Japan Canada were collected. Clinical, procedural, data evaluated between two groups. was successfully by 129 (99%) 130 134 (100%) access. Patients...
Patients undergoing structural heart interventions often require large-sized sheath insertion into femoral arteries and veins. Clinical outcome data on the use of suture-mediated devices for large arterial access in is limited. We assessed efficacy Perclose™ (Abbott Vascular Devices, Santa Clara, CA, USA) device using pre-closure technique achieving hemostasis sites following (≥8 Fr).One hundred consecutive patients underwent 101 artery closures with Perclose technique. Sixty-two percent...
Introduction Acute myocardial infarction (AMI) remains a major cause of mortality and morbidity worldwide despite the latest therapeutic advances designed to decrease injury. Preclinical emerging clinical evidence show that intracoronary injection autologous bone marrow mononuclear cells (BMCs) following AMI leads improvement in left ventricular ejection function (LVEF). In this trial we will for first time assess effect early (<24 h) infusion BMCs on cardiac function. Methods analysis...
Patients with prior coronary artery bypass graft (CABG) surgery often require percutaneous intervention (PCI). Data are still limited in regards to the outcomes of native saphenous vein (SVG) PCI after CABG.We performed a retrospective study tertiary reference cardiac center consecutive patients who underwent CABG. The data were collected for either or from January 2008 December 2018. Arterial PCIs excluded. Multivariable Cox regression analysis propensity matching was performed, and major...