A5102940177- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Magnetic properties of thin films
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Pluripotent Stem Cells Research
- Ultrasonics and Acoustic Wave Propagation
- Advanced Memory and Neural Computing
- Angiogenesis and VEGF in Cancer
- Diet and metabolism studies
- Robot Manipulation and Learning
- Sensor Technology and Measurement Systems
- Muscle activation and electromyography studies
- Glioma Diagnosis and Treatment
- Meat and Animal Product Quality
- Pregnancy and preeclampsia studies
- Coronary Interventions and Diagnostics
- Demographic Trends and Gender Preferences
- Aortic aneurysm repair treatments
- Organ Transplantation Techniques and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetes and associated disorders
- Voice and Speech Disorders
- Muscle metabolism and nutrition
- Ferroelectric and Negative Capacitance Devices
University College London
2014-2024
General Dynamics (United States)
2024
Bury College
2017-2024
The Graduate Center, CUNY
2020-2021
Center for Discovery
2021
Imperial College London
2019
Utrecht University
2019
University of Amsterdam
2019
Amsterdam UMC Location University of Amsterdam
2019
St. Luke's International Hospital
2019
Human physical performance is strongly influenced by genetic factors. A variation in the structure of human angiotensin I-converting enzyme (ACE) gene has been reported which insertion (I) variant associated with lower ACE levels than deletion (D) gene. We have previously that I was improved endurance high-altitude mountaineers and British Army recruits. now examine this genotype distribution 91 Olympic-standard runners (79 Caucasians). DNA extracted from buccal cells contained 10 ml saline...
Clinical trials suggest that intracoronary delivery of autologous bone marrow-derived cells (BMCs) 1–7 days post-acute myocardial infarction (AMI) may improve left ventricular (LV) function. Earlier time points have not been evaluated. We sought to determine the effect BMC on LV function when delivered within 24 h successful reperfusion therapy. A multi-centre phase II randomized, double-blind, and placebo-controlled trial. One hundred patients with anterior AMI significant regional wall...
Sulfide-releasing compounds reduce reperfusion injury by decreasing mitochondria-derived reactive oxygen species production. We previously characterised ammonium tetrathiomolybdate (ATTM), a clinically used copper chelator, as sulfide donor in rodents. Here we assessed translation to large mammals prior clinical testing. In healthy pigs an intravenous ATTM dose escalation revealed reproducible pharmacokinetic/pharmacodynamic (PK/PD) relationship with minimal adverse or biochemical events....
Early revascularization of ischemic organs is key to improving outcomes, yet consequent reperfusion injury may be harmful. Reperfusion largely attributed excess mitochondrial production reactive oxygen species (ROS). Sulfide inhibits mitochondria and reduces ROS production. Ammonium tetrathiomolybdate (ATTM), a copper chelator, releases sulfide in controlled novel manner, offer potential therapeutic utility.
Over the past 13 years bone marrow‐derived mononuclear cells ( BM‐MNCs ) have been widely investigated for clinical efficacy in patients following acute myocardial infarction AMI ). These early phase II trials used various surrogate markers to judge and, although promising, results inconsistent. The III BAMI trial has therefore designed demonstrate that intracoronary infusion of is safe and will significantly reduce time first occurrence all‐cause death with reduced left ventricular ejection...
SummaryInbreeding coefficients are reported for all members of the isolated Havasupai tribe northern Arizona (USA), based upon pedigrees which as deep eight generations. Because inbreeding has been repeatedly shown to reduce developmental homeostasis in a large number species, we ask if degree is associated with reduced stability. Fluctuating asymmetry two dermatoglyphic traits suggests that significantly compromises this population.ZusammenfassungFür alle Mitglieder des im nördlichen (USA)...
Neoadjuvant chemo-radiation therapy including temozolomide is commonly used for the treatment of gliomas. However, increased lesion size and contrast enhancement are frequently observed following this appearance termed as 'pseudo-progression'. Since conventional imaging unable to differentiate pseudo-progression from tumour recurrence, we evaluated utility MR spectroscopy (MRS) these two pathological entities. Longitudinal MRI MRS studies prior within four months post diffusion-weighted...
The authors studied 211 patients with glioblastoma multiforme, verified micro¬ scopically. In a series of 860 intracranial tumors there were 455 gliomas. diagnosed as multiforme constituted 29.5 per cent the total number and 46.4 All but 8 these followed to time death. Of group 211, 24 moribund when admitted hospital died before any surgi¬ cal procedures carried out. diagnosis was by autopsy. On remaining 187 225 operations performed, and, patients. 77 in within one month after operation....
Bone marrow stem cell (BMSC) therapy for cardiovascular disease has shown considerable preclinical and clinical promise, but there remains a need mechanistic studies to help bridge the transition from bench bedside. We have designed substudy our REGENERATE-IHD trial (ClinicalTrial.gov Identifier: NCT00747708) assess feasibility of novel imaging technique detect angiogenesis following BMSC therapy.Nine patients who had been randomized receive intracoronary injection G-CSF-mobilized BMSCs or...
Aim: This study presents an interim safety and feasibility analysis of the REGENERATE-IHD randomized controlled trial, which is examining efficacy three different delivery routes bone marrow-derived stem cells (BMSCs) in patients with ischemic heart failure. Methods & results: The first 58 recruited to are included this (pilot). Symptomatic failure were receive subcutaneous granulocyte colony-stimulating factor or saline injections only; followed by intracoronary intramyocardial BMSCs serum...
The insertion of a stent in diseased arteries is common endovascular procedure that can be compromised by the development short- and long-term inflammatory responses leading to restenosis thrombosis, respectively. While treatment with drugs, either systemic or localized, has decreased incidence thrombosis these complications persist are associated high mortality those present thrombosis. We reasoned if stents could made undergo accelerated endothelialization deployed region, then such an...
Abstract Aims The long‐term outcomes of the intracoronary delivery autologous bone marrow‐derived cells (BMCs) after acute myocardial infarction are not well established. Following promising 1 year results REGENERATE‐AMI trial (despite it achieving its primary endpoint), this paper presents analysis 5 clinical these patients who were treated with an early BMC infusion or placebo. Methods and A follow‐up major adverse cardiac events (defined as composite all‐cause death, recurrent infarction,...
The offspring and grandoffspring of female rats fed low protein diets during pregnancy lactation, but nutritionally adequate thereafter, have been shown to exhibit altered insulin sensitivity in adulthood. current study investigates the pregnancy, then maintained on energy-restricted post weaning over three generations.Female Sprague Dawley (F0) were mated with control males malnourished pregnancy/lactation. F1 weaned into dams throughout F2 also weaning. pregnant as described above. Their...
In 1923, one of us<sup>1</sup>called attention to the clinical syndrome produced by lesions paratrigeminal area. this small anatomic space are located sensory and motor roots fifth cranial nerve, gasserian ganglion its three branches, carotid artery plexus sympathetic nerve fibers which surround it, oculomotor, trochlear abducens nerves innervate extra-ocular muscles (fig. 1). Obviously, with all these important structures crowded into a area potentialities many symptoms from even very...