José Alberto San Román
A5078850591- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Antimicrobial Resistance in Staphylococcus
- Aortic Disease and Treatment Approaches
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Streptococcal Infections and Treatments
- Acute Myocardial Infarction Research
- Mechanical Circulatory Support Devices
- Infectious Aortic and Vascular Conditions
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Aortic aneurysm repair treatments
- Heart Failure Treatment and Management
- Pulmonary Hypertension Research and Treatments
- Advanced MRI Techniques and Applications
- Congenital Heart Disease Studies
- Mesenchymal stem cell research
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
Hospital Clínico Universitario de Valladolid
2016-2025
Centro de Investigación Biomédica en Red
2017-2025
Centro de Investigación en Red en Enfermedades Cardiovasculares
2017-2025
Universidad de Valladolid
2001-2025
Instituto de Salud Carlos III
2017-2024
Universidad de Santiago de Chile
2024
Comunidad de Madrid
2023
Centre for Biomedical Network Research on Rare Diseases
2022
Clinique Pasteur
2017-2021
Institute of Cardiology
2021
The ESC Guidelines represent the views of and were arrived at after careful consideration available evidence time they written.Health professionals are encouraged to take them fully into account when exercising their clinical judgement.The guidelines do not, however, override individual responsibility health make appropriate decisions in circumstances patients, consultation with that patient, where necessary patient's guardian or carer.It is also professional's verify rules regulations...
Bone marrow mononuclear cells (BMCs) from 20 patients with extensive reperfused myocardial infarction (MI) were used to assess their regenerative capability “in vitro” and effect on postinfarction left ventricular (LV) remodeling. Human BMCs labeled, seeded top of cryoinjured mice heart slices, cultured. showed tropism for ability graft into the damaged mouse cardiac tissue and, after 1 week, acquired a cardiomyocyte phenotype expressed proteins, including connexin43. In clinical trial,...
Background— The objective of this study was to evaluate the timing, predictive factors, and prognostic value cerebrovascular events (CVEs) after transcatheter aortic valve implantation. Methods Results— included 1061 consecutive patients who underwent implantation with a balloon-expandable (64%) or self-expandable (36%) valve. CVEs were classified as acute (≤24 hours), subacute (1–30 days), late (>30 days). occurred in 54 (5.1%; stroke, 4.2%) within 30 days (acute 54% cases). predictors...
<h3>Importance</h3> Limited data exist on clinical characteristics and outcomes of patients who had infective endocarditis after undergoing transcatheter aortic valve replacement (TAVR). <h3>Objective</h3> To determine the associated factors, characteristics, TAVR. <h3>Design, Setting, Participants</h3> The Infectious Endocarditis TAVR International Registry included with definite from 47 centers Europe, North America, South America between June 2005 October 2015. <h3>Exposure</h3>...
Background— We aimed to determine the incidence, predictors, clinical characteristics, management, and outcomes of infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI). Methods Results— This multicenter registry included 53 patients (mean age, 79±8 years; men, 57%) who suffered IE TAVI 7944 a mean follow-up 1.1±1.2 years (incidence, 0.67%, 0.50% within first year TAVI). Mean time from was 6 months (interquartile range, 1–14 months). Orotracheal intubation (hazard...
We aimed to determine whether treatment with sildenafil improves outcomes of patients persistent pulmonary hypertension (PH) after correction valvular heart disease (VHD).
Abstract Aims The respective roles of oral anticoagulation or antiplatelet therapy following transcatheter aortic valve implantation (TAVI) remain debated. ATLANTIS is an international, randomized, open-label, superiority trial comparing apixaban to the standard care. Methods and results After successful TAVI, 1500 patients were randomized (1:1) receive 5 mg (2.5 if impaired renal function concomitant therapy) (n = 749) twice daily, care 751). Randomization was stratified by need for chronic...
Aims To investigate the clinical features, echocardiographic characteristics, management, and prognostic factors of mortality aorto-cavitary fistulization (ACF) in infective endocarditis (IE). Extension infection aortic valve IE beyond valvular structures may result peri-annular complications with resulting necrosis rupture, subsequent development ACF. Aorto-cavitary communications create intra-cardiac shunts, which further deterioration haemodynamic instability. Methods results In a...
To compare primary percutaneous coronary intervention (pPCI) and fibrinolysis in very old patients with ST-segment elevation myocardial infarction (STEMI), whom head-to-head comparisons between both strategies are scarce.
There is no agreement in the best cutoff time to distinguish between early- and late- onset prosthetic valve endocarditis (PVE). Our objectives are define early-onset PVE according microbiological spectrum analyse profile short-term prognosis of this entity.The 172 non-drug users, who were patients with PVE, compared elapsed from surgery among 640 diagnosed 1996 2004. differences occurred within 2 months replacement those accounting 12 months. The proportion coagulase-negative Staphylococci...
The prognosis of patients with infective endocarditis (IE) remains poor despite the great advances in last decades. One factors closely related to mortality is development septic shock (SS). aim our study was describe profile IE complicated SS, and identify prognostic new-onset SS during hospitalization. We conducted a prospective including 894 episodes diagnosed at three tertiary centres. A backward logistic regression analysis undertaken determine associated development. Multivariable...
Traumatic spinal cord injury (SCI) induces tissue damage and results in the formation of a cavity that inhibits axonal regrowth. Filling this with growth-permissive substrate would likely promote regeneration repair. Single-walled carbon nanotubes functionalized polyethylene glycol (SWNT-PEG) have been shown to increase length selected neurites vitro. We hypothesized administration SWNT-PEG after experimental SCI will axons into lesion functional recovery hindlimbs. To evaluate hypothesis,...
<h3>Objective</h3> To develop and validate a calculator to predict the risk of in-hospital mortality in patients with active infective endocarditis (IE) undergoing cardiac surgery. <h3>Methods</h3> Thousand two hundred ninety-nine consecutive IE were prospectively recruited (1996–2014) retrospectively analysed. Left-sided who underwent surgery (n=671) form our study population randomised into development (n=424) validation (n=247) samples. Variables statistically significant in-mortality...
Introduction: Coronavirus disease 2019 (COVID-19) is a systemic characterized by disproportionate inflammatory response in the acute phase. This study sought to identify clinical sequelae and their potential mechanism. Methods: We conducted prospective single-center (NCT04689490) of previously hospitalized COVID-19 patients with without dyspnea during mid-term follow-up. An outpatient group was also evaluated. They underwent serial testing cardiopulmonary exercise test (CPET), transthoracic...