Hervé Breton
A5074372500- Cardiac Valve Diseases and Treatments
- Education, sociology, and vocational training
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Health, Medicine and Society
- Healthcare Systems and Practices
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- French Urban and Social Studies
- Cardiac Structural Anomalies and Repair
- Linguistics and Discourse Analysis
- Aortic Disease and Treatment Approaches
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Multiculturalism, Politics, Migration, Gender
- Venous Thromboembolism Diagnosis and Management
- Psychoanalysis and Psychopathology Research
- Heart Failure Treatment and Management
- Social Policies and Family
- Social Sciences and Governance
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
Centre Hospitalier Universitaire de Rennes
2016-2025
Université de Tours
2016-2025
Inserm
2016-2025
Institut Universitaire de France
2023-2025
Université de Rennes
2016-2025
CIC Rennes
2009-2025
Laboratoire Traitement du Signal et de l'Image
2015-2024
Hôpital Pontchaillou
2013-2023
Sorbonne Université
1996-2020
Assistance Publique – Hôpitaux de Paris
2001-2020
Transcatheter aortic-valve implantation (TAVI) is an emerging intervention for the treatment of high-risk patients with severe aortic stenosis and coexisting illnesses. We report results a prospective multicenter study French national transcatheter registry, FRANCE 2.
Experimental and clinical evidence suggests that cyclosporine may attenuate reperfusion injury reduce myocardial infarct size. We aimed to test whether would improve outcomes prevent adverse left ventricular remodeling.In a multicenter, double-blind, randomized trial, we assigned 970 patients with an acute anterior ST-segment elevation infarction (STEMI) who were undergoing percutaneous coronary intervention (PCI) within 12 hours after symptom onset had complete occlusion of the culprit...
Gilard, Martine; Eltchaninoff, Hélène; Iung,, Bernard; Donzeau-Gouge, Patrick; Chevreul, Karine; Fajadet, Jean; Leprince, Pascal; Leguerrier, Alain; Lievre, Michel; Prat, Teiger, Emmanuel; Lefevre, Thierry; Himbert, Dominique; Tchetche, Didier; Carrié, Albat, Cribier, Rioufol, Gilles; Sudre, Arnaud; Blanchard, Collet, Frederic; Dos Santos, Pierre; Meneveau, Nicolas; Tirouvanziam, Ashok; Caussin, Christophe; Guyon, Philippe; Boschat, Jacques; Le Breton, Herve; Collart, Houel, Remi; Delpine,...
To improve the definition of various clinical patterns patients with drug-induced cutaneous side-effects systemic symptoms, and their possible relationships triggering medication, ultimate goal helping in identification causal drug difficult situations when patient is taking several drugs.Cases associated syndromes related to anticonvulsants (carbamazepine, phenytoin phenobarbitone), minocycline, allopurinol, abacavir nevirapine were collected retrospectively from French Pharmacovigilance...
<h3>Importance</h3> Limited data exist on clinical characteristics and outcomes of patients who had infective endocarditis after undergoing transcatheter aortic valve replacement (TAVR). <h3>Objective</h3> To determine the associated factors, characteristics, TAVR. <h3>Design, Setting, Participants</h3> The Infectious Endocarditis TAVR International Registry included with definite from 47 centers Europe, North America, South America between June 2005 October 2015. <h3>Exposure</h3>...
International guidelines recommend an early invasive strategy for patients with high-risk acute coronary syndromes without ST-segment elevation, but the optimal timing of intervention is uncertain.To determine whether immediate on admission can result in a reduction myocardial infarction compared delayed intervention.The Angioplasty to Blunt Rise Troponin Acute Coronary Syndromes Randomized Immediate or Delayed Intervention (ABOARD) study, randomized clinical trial that assigned, from August...
Abstract Aims The respective roles of oral anticoagulation or antiplatelet therapy following transcatheter aortic valve implantation (TAVI) remain debated. ATLANTIS is an international, randomized, open-label, superiority trial comparing apixaban to the standard care. Methods and results After successful TAVI, 1500 patients were randomized (1:1) receive 5 mg (2.5 if impaired renal function concomitant therapy) (n = 749) twice daily, care 751). Randomization was stratified by need for chronic...
This paper describes a preliminary experiment ‐ conducted jointly by 2 centers of permanent left ventricular pacing using leads inserted the transvenous route and through coronary sinus into cardiac veins ventricle free wall. The aim was to obtain biventricular in totally endocavitary configuration pattents with severe LV dysfunction drug‐refractory heart failure. Two types were used: nonspecific unipolar at beginning experiment, followed specifically designed be used second step. electrode...
Background Moderate anticoagulation may be proposed to reduce the risk of hemorrhage for certain patients with a mechanical prosthesis, but consequences thromboembolism are debated. Methods and Results The purpose AREVA trial was compare moderate oral (international normalized ratio [INR] 2.0 3.0) usual regimen (INR 3.0 4.5) after single-valve replacement either Omnicarbon or St Jude. Patients included were between 18 75 years old, in sinus rhythm, left atrial diameter ≤50 mm on time-motion...
<h3>Objective</h3> To compare transthoracic and transoesophageal echocardiography (TTE, TOE) in patients with permanent pacemaker lead infection to evaluate the safety of medical extraction cases large vegetations. <h3>Methods</h3> TTE TOE were performed 23 definite infection. Seventeen without previous served as a reference for non-infected leads. <h3>Results</h3> was positive seven (30%) whereas three different types vegetations attached leads visualised 21 (91%). Of 20 culture, 17 (85%)...
Background: No randomized study powered to compare balloon expandable (BE) with self expanding (SE) transcatheter heart valves (THVs) on individual end points after aortic valve replacement has been conducted date. Methods: From January 2013 December 2015, the FRANCE-TAVI nationwide registry (Registry of Aortic Valve Bioprostheses Established by Catheter) included 12 141 patients undergoing BE-THV (Edwards, n=8038) or SE-THV (Medtronic, n=4103) for treatment native stenosis. Long term...
The FRANCE-2 registry (French Aortic National Corevalve and Edwards) previously reported good early- medium-term clinical echocardiographic efficacy for transcatheter aortic valve replacement. We here report 5-year follow-up results from the registry.The includes all consecutive patients undergoing replacement severe stenosis in France. Follow-up is scheduled at 30 days, 6 months, then annually 1 to 5 years. Clinical events were defined according Valve Academic Research Consortium criteria,...
Background— Pulmonary hypertension (PH) is associated with poor prognosis in patients severe aortic stenosis. The aim of this multicenter study was to describe clinical outcome after transcatheter valve implantation. Methods and Results— FRANCE 2 Registry included all undergoing implantation France 2010 2011. Patients were divided into 3 groups depending on systolic pulmonary artery pressure (sPAP) estimated transthoracic echocardiography: group I, sPAP <40 mm Hg (no PH); II, 40 59...
Femoral access is the gold standard for transcatheter aortic valve replacement (TAVR). Guidelines recommend reconsidering surgery when this not feasible. However, alternative peripheral accesses exist, although they have been accurately compared with femoral access. This study nonfemoral (n-FP) TAVR TAVR. Using data from national prospective French registry (FRANCE TAVI [French Transcatheter Aortic Valve Implantation]), characteristics and outcomes of procedures according to whether were...
To derive and validate a readily useable risk score to identify patients at high-risk of in-hospital ST-segment elevation myocardial infarction (STEMI)-related cardiogenic shock (CS).In all, 6838 without CS on admission treated by primary percutaneous coronary intervention (pPCI), included in the Observatoire Régional Breton sur l'Infarctus (ORBI), served as derivation cohort, 2208 obseRvatoire des Infarctus de Côte-d'Or (RICO) constituted external validation cohort. Stepwise multivariable...
Two cases of transient acute cardiomyopathy occurring in the immediate aftermath intense emotional stress and without any identified aetiology are described. These two case reports, mimicking described patients with pheochromocytoma, suggest possibility man catecholamine induced related to major alone, a phenomenon so far reported only animal experimental models.