Patrice Guérin
A5014601209- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Mechanical Circulatory Support Devices
- Coronary Artery Anomalies
- Cardiovascular and Diving-Related Complications
- Aortic Disease and Treatment Approaches
- Acute Myocardial Infarction Research
- Cardiac pacing and defibrillation studies
- Pulmonary Hypertension Research and Treatments
- Cardiac Arrhythmias and Treatments
- Vascular anomalies and interventions
- Cardiovascular Conditions and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Peripheral Artery Disease Management
- Radiation Dose and Imaging
- Tracheal and airway disorders
- Aortic aneurysm repair treatments
- Cerebrovascular and Carotid Artery Diseases
Centre Hospitalier Universitaire de Nantes
2016-2025
Institut du Thorax
2015-2024
Inserm
2012-2024
Nantes Université
2007-2024
Centre National de la Recherche Scientifique
2019-2024
Hôpital Laennec
2002-2022
RMeS - Regenerative Medicine and Skeleton
2020-2022
Emergent BioSolutions (United Kingdom)
2022
Scientific Centre of Monaco
2019-2021
Centre d'Investigation Clinique de Nantes
2013-2021
In patients who have chronic heart failure with reduced left ventricular ejection fraction, severe secondary mitral-valve regurgitation is associated a poor prognosis. Whether percutaneous repair improves clinical outcomes in this patient population unknown.We randomly assigned had mitral (defined as an effective regurgitant orifice area of >20 mm2 or volume >30 ml per beat), fraction between 15 and 40%, symptomatic failure, 1:1 ratio, to undergo addition receiving medical therapy...
Trials of patent foramen ovale (PFO) closure to prevent recurrent stroke have been inconclusive. We investigated whether patients with cryptogenic and echocardiographic features representing risk would benefit from PFO or anticoagulation, as compared antiplatelet therapy.In a multicenter, randomized, open-label trial, we assigned, in 1:1:1 ratio, 16 60 years age who had recent attributed PFO, an associated atrial septal aneurysm large interatrial shunt, transcatheter plus long-term therapy...
Experimental and clinical evidence suggests that cyclosporine may attenuate reperfusion injury reduce myocardial infarct size. We aimed to test whether would improve outcomes prevent adverse left ventricular remodeling.In a multicenter, double-blind, randomized trial, we assigned 970 patients with an acute anterior ST-segment elevation infarction (STEMI) who were undergoing percutaneous coronary intervention (PCI) within 12 hours after symptom onset had complete occlusion of the culprit...
<h3>Importance</h3> Although an emergency coronary angiogram (CAG) is recommended for patients who experience out-of-hospital cardiac arrest (OHCA) with ST-segment elevation on the postresuscitation electrocardiogram (ECG), this strategy still debated in without elevation. <h3>Objective</h3> To assess 180-day survival rate Cerebral Performance Category (CPC) 1 or 2 of OHCA ECG and undergo CAG vs delayed CAG. <h3>Design, Setting, Participants</h3> The Emergency Delayed Coronary Angiogram...
Importance Correction of tricuspid regurgitation using transcatheter edge-to-edge repair (T-TEER) in addition to guideline-directed optimized medical therapy (OMT) may improve clinical outcomes. Objective To evaluate the efficacy T-TEER + OMT vs alone patients with severe, symptomatic regurgitation. Design, Setting, and Participants Investigator-initiated, prospective, randomized (1:1) trial evaluating adult The was conducted at 24 centers France Belgium (March 2021 March 2023; latest...
Tricuspid regurgitation (TR) is a common and progressive valve disease with significant mortality hospitalization burden. transcatheter edge-to-edge repair provides treatment option for high-risk patients primary secondary TR. The TRILUMINATE trial ([Trial to Evaluate Treatment With Abbott Transcatheter Clip Repair System in Patients Moderate or Greater Regurgitation]; n=85) an international, prospective, single-arm, multicenter study investigate the safety performance of tricuspid TriClip...
Abstract Background and Aims Mitral valve surgery and, more recently, mitral transcatheter edge-to-edge repair (TEER) are the two treatments of severe regurgitation in eligible patients. Clinical comparison both therapies remains limited by number patients analysed. The objective this study was to analyse outcomes TEER vs. isolated at a nationwide level France. Methods Based on French administrative hospital discharge database, collected information for all consecutive treated with or...
Inhibition of the type 5 phosphodiesterase and inhibition Rho kinase are both effective in reducing pulmonary hypertension (PH). Here we investigate whether is involved beneficial effect inhibitor sildenafil on PH. Chronic hypoxia-induced PH rats associated with an increase RhoA activity artery that was maximal after 2 days (10.7+/-0.9-fold increase, n=6, P<0.001). The assessed by measuring level myosin phosphatase target subunit 1 (MYPT1) phosphorylation also increased (5.7+/-0.8-fold over...
Hyaluronan (HA) is an important constituent of the extracellular matrix and known to regulate cellular events through binding CD44 receptor for HA-mediated motility (RHAMM). Here we investigated role these receptors signaling pathways involved in effects arterial smooth muscle cells (ASMC).Effects high-molecular weight HA (1 5 mg/ml) were analyzed cultured ASMC from rat aorta.HA promoted actin stress fiber lamellipodia formation dose-dependently induced migration without effect on...
Background— The use of a drug-eluting stent (DES) has strongly limited the incidence in-stent restenosis in bifurcation lesions; nevertheless, still remains problem at origin side branch. aim this study is to analyze consequences kissing postdilatation technique on 5 DESs, using microfocus x-ray computerized tomography and scanning electron microscopy. Methods Results— Five different DESs (Cypher, Cypher Select, Endeavor, Taxus Express, Liberté) were deployed protocols bench-top model. For...
Aims:We aimed to evaluate the role of drug-eluting balloon SB inflation, using novel DANUBIO balloon, after placement a stent in main branch patients with bifurcation lesions.Methods and results: Fifty-two lesions suitable for stenting were enrolled DEBSIDE trial at eight French centres between May 2012 July 2013.Two excluded from because significant protocol deviations.Systematic Nile PAX was followed by final according size side branch.Clinical follow-up scheduled one, six, twelve months...
Morphine is commonly used to treat chest pain during myocardial infarction, but its effect on cardiovascular outcome has never been directly evaluated. The aim of this study was examine the and safety morphine in patients with acute anterior ST-segment elevation infarction followed up for 1 year.We database CIRCUS (Does Cyclosporine Improve Outcome ST Elevation Myocardial Infarction Patients) trial, which included 969 admitted primary percutaneous coronary intervention. Two groups were...
Abstract Background and Aims Transcatheter pulmonary valve implantation (TPVI) is indicated to treat right-ventricular outflow tract (RVOT) dysfunction related congenital heart disease (CHD). Outcomes of TPVI with the SAPIEN 3 that are insufficiently documented were investigated in EUROPULMS3 registry 3-TPVI. Methods Patient-related, procedural, follow-up outcome data retrospectively assessed this observational cohort from 35 centres 15 countries. Results Data for 840 consecutive patients...
Background The aim of this study was to assess health-related quality life in patients with pulmonary arterial hypertension associated CHD and correlations clinical status. Methods This prospective cross-sectional observational included 14 tertiary-care centres France. We used two questionnaires – SF-36 Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) one anxiety/depression Hospital Anxiety Depression Scale (HADS) questionnaire. Results Clinical data were collected for the 208 (mean...