A5013431327- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiovascular Issues in Pregnancy
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Coronary Artery Anomalies
- Venous Thromboembolism Diagnosis and Management
- Heart Failure Treatment and Management
- Cardiovascular and Diving-Related Complications
- Infective Endocarditis Diagnosis and Management
- Cardiac pacing and defibrillation studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Imaging and Diagnostics
- Aortic Disease and Treatment Approaches
- Transplantation: Methods and Outcomes
- Cardiac tumors and thrombi
- Vascular Anomalies and Treatments
- Vascular anomalies and interventions
- Mechanical Circulatory Support Devices
- Tracheal and airway disorders
- Cardiovascular Effects of Exercise
- Healthcare Policy and Management
- Renal and Vascular Pathologies
Royal Brompton Hospital
2016-2025
Harefield Hospital
2013-2025
Imperial College London
2015-2024
Guy's and St Thomas' NHS Foundation Trust
2021-2024
St Thomas' Hospital
2020-2024
Royal Brompton & Harefield NHS Foundation Trust
2013-2024
Lung Institute
2010-2023
United Nations Industrial Development Organization
2022
Government of the United Kingdom
2022
Rigshospitalet
2016-2021
Adult congenital heart disease (ACHD) patients have ongoing morbidity and reduced long-term survival. Recently, the importance of specialized follow-up at tertiary ACHD centers has been highlighted. We aimed to assess survival prospects clarify causes death in a large cohort single, center.We included 6969 adult (age 29.9 ± 15.4 years) under our institution between 1991 2013. Causes were ascertained from official certificates. Survival was compared with expected general age- sex-matched...
Patients with severe aortic stenosis and reduced left ventricular ejection fraction (LVEF) have a poor prognosis conservative therapy but high operative mortality when treated surgically. Recently, transcatheter valve implantation (TAVI) has emerged as an alternative to surgical replacement (SAVR) for patients considered at or prohibitive risk. The objective of this study was compare TAVI SAVR respect postoperative recovery LVEF in LV systolic function.Echocardiographic data were...
Background— Sudden cardiac death and life-threatening ventricular arrhythmia remain a concern in adult patients with repaired tetralogy of Fallot. Longitudinal left (LV) function is sensitive detecting early myocardial damage may have prognostic implications this setting. Methods Results— We included 413 Fallot (age, 36±13 years; QRS duration, 148±27 milliseconds; LV ejection fraction, 55±10%). A composite end point sudden death/life-threatening (sustained tachycardia, resuscitated death, or...
The population of adults with congenital heart disease (ACHD) is growing and ageing. Limited information about the diagnostic spectrum this emerging population, its resource utilization at tertiary ACHD centres, especially prognostic parameters available. Retrospective cohort study on all patients ≥60 years age under active follow-up. All-cause mortality was primary outcome measure. Out a total 7315 patients, 375 [190 females (50.7%), mean 64.8 ± 5.9 years] fulfilled inclusion criteria....
To assess the utility of machine learning algorithms on estimating prognosis and guiding therapy in a large cohort patients with adult congenital heart disease (ACHD) or pulmonary hypertension at single, tertiary centre. We included 10 019 (age 36.3 ± 17.3 years) under follow-up our institution between 2000 2018. Clinical demographic data, ECG parameters, cardiopulmonary exercise testing, selected laboratory markers where collected deep (DL) algorithms. Specific DL-models were built based...
Background— Restrictive lung defects are associated with higher mortality in patients acquired chronic heart failure. We investigated the prevalence of abnormal function, its relation to severity underlying cardiac defect, surgical history, and impact on outcome across spectrum adult congenital disease. Methods Results— A total 1188 disease (age, 33.1±13.1 years) undergoing function testing between 2000 2009 were included. Patients classified according dysfunction based predicted values...
Parameters of myocardial deformation have been suggested to be superior conventional measures ventricular function in patients with tetralogy Fallot (ToF), but required non-routine, tagged cardiovascular magnetic resonance (CMR) techniques. We assessed biventricular using CMR cine-based feature tracking (FT) and compared it speckle echocardiography (STE) simple endocardial border delineation (EBD). In addition, the relation between parameters clinical was assessed. Overall, 28 consecutive...
<h3>Background</h3> Parameters of myocardial deformation have been suggested to be superior conventional measures ventricular function and predict outcome in repaired tetralogy Fallot (ToF). We aimed test the hypothesis that parameters on cardiac MRI (CMR) relate symptoms provide prognostic information patients with ToF. <h3>Methods results</h3> included 372 ToF (median age 16 years; 55% male), recruited within a nationwide, prospective study. Longitudinal (LS), circumferential (CS) radial...
Eisenmenger syndrome is associated with substantial morbidity and mortality. There no consensus, however, on mortality risk stratification. We aimed to investigate survival predictors of death in a large, contemporary cohort patients.In multicenter approach, we identified adults under follow-up between 2000 2015. examined its association clinical, electrocardiographic, echocardiographic, laboratory parameters.We studied 1098 patients (median age, 34.4 years; range, 16.1-84.4 65.1% female;...
Background— Eisenmenger syndrome differs significantly from other types of pulmonary arterial hypertension in its physiology and prognosis. We sought to assess the relationship between echocardiographic characteristics patients with mortality. Methods Results— Clinical variables were assessed 181 consecutive syndrome, excluding those complex congenital heart disease. Patients' mean age was 39.1±12.8 years, 59 (32.6%) male, 122 (67.4%) functional class III or higher, 74 (40.9%) on advanced...
This study sought to identify patients with repaired tetralogy of Fallot (rTOF) at high risk death and malignant ventricular arrhythmia (VA).To date there is no robust stratification scheme predict outcomes in adults rTOF.Consecutive were prospectively recruited for late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) define right left (RV, LV) fibrosis addition proven markers.The primary endpoint was all-cause mortality. Of the 550 (median age 32 years, 56% male), 27...
To evaluate the late outcomes of adults (above 35 years) with a Fontan-type circulation, for whom current data on morbidity and mortality are lacking.
<h3>Objective</h3> To assess the relationship between elevated levels of B-type natriuretic peptide (BNP) and outcome in patients with Eisenmenger syndrome. <h3>Design</h3> Retrospective study. <h3>Setting</h3> Tertiary centre for adult congenital heart disease. <h3>Patients</h3> All syndrome (n=181, age 36.9±12.1 years, 31% Down syndrome) whom BNP concentrations were measured as part routine clinical care included. <h3>Main measures</h3> The study end point was all cause mortality....
Eisenmenger syndrome (ES) is associated with considerable morbidity and mortality. Therapeutic strategies have changed during the 2000s in conjunction an emphasis on specialist follow-up. The aim of this study was to determine cause-specific mortality ES evaluate any relevant changes between 1977 2015.This a retrospective, descriptive multicentre study. A total 1546 patients (mean age 38.7 ± 15.4 years; 36% male) from 13 countries were included. Cause-specific examined before after July...
Repaired tetralogy of Fallot (rtoF) patients are at risk atrial or ventricular tachyarrhythmia and sudden cardiac death. Risk stratification for arrhythmia remains difficult. We investigated whether anatomy function predict arrhythmia.One-hundred-and-fifty-four adults with rtoF, median age 30.8 (21.9-40.2) years, were studied a standardised protocol including cardiovascular magnetic resonance (CMR) prospectively followed up over 5.6 (4.6-7.0) years the pre-specified endpoints new-onset...
Infective endocarditis (IE) is associated with significant morbidity and mortality. Patients adult congenital heart disease (ACHD) have an increased risk of developing IE. The aim this study to describe the incidence, predictors outcome mortality IE in ACHD a contemporary cohort.All episodes adults referred our tertiary centre between 1999 2013 were included study. identified from hospital database. diagnosis was established according modified Duke criteria. primary endpoint...
Abstract Aims To investigate the utility of novel deep learning (DL) algorithms in recognizing transposition great arteries (TGA) after atrial switch procedure or congenitally corrected TGA (ccTGA) based on routine transthoracic echocardiograms. In addition, ability DL for delineation and segmentation systemic ventricle was evaluated. Methods results total, 132 patients (92 40 with ccTGA; 60% male, age 38.3 ± 12.1 years) 67 normal controls (57% 48.5 17.9 examinations were included....