A5081550777- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Cardiovascular Issues in Pregnancy
- Coronary Artery Anomalies
- Metabolism and Genetic Disorders
- Aortic Disease and Treatment Approaches
- Cardiovascular and Diving-Related Complications
- Cardiac pacing and defibrillation studies
- Infective Endocarditis Diagnosis and Management
- Porphyrin Metabolism and Disorders
- Cardiac Imaging and Diagnostics
- Tracheal and airway disorders
- Advanced MRI Techniques and Applications
- Biochemical and Molecular Research
- Genomic variations and chromosomal abnormalities
- Autoimmune Bullous Skin Diseases
- Dermatological and Skeletal Disorders
- Skin and Cellular Biology Research
- Renal and Vascular Pathologies
- Cutaneous lymphoproliferative disorders research
- Vascular anomalies and interventions
University Hospital Schleswig-Holstein
2012-2025
University of Lübeck
2012-2025
German Centre for Cardiovascular Research
2018-2025
Kiel University
1998-2024
Royal Brompton Hospital
2012-2023
University Hospital Münster
2015-2023
Deutsches Herzzentrum München
2003-2023
Universitäts Hautklinik Kiel
2022
Harefield Hospital
2013-2021
Guy's and St Thomas' NHS Foundation Trust
2021
Adult congenital heart disease (ACHD) patients have ongoing morbidity and reduced long-term survival. Recently, the importance of specialized follow-up at tertiary ACHD centers has been highlighted. We aimed to assess survival prospects clarify causes death in a large cohort single, center.We included 6969 adult (age 29.9 ± 15.4 years) under our institution between 1991 2013. Causes were ascertained from official certificates. Survival was compared with expected general age- sex-matched...
Background— Sudden cardiac death and life-threatening ventricular arrhythmia remain a concern in adult patients with repaired tetralogy of Fallot. Longitudinal left (LV) function is sensitive detecting early myocardial damage may have prognostic implications this setting. Methods Results— We included 413 Fallot (age, 36±13 years; QRS duration, 148±27 milliseconds; LV ejection fraction, 55±10%). A composite end point sudden death/life-threatening (sustained tachycardia, resuscitated death, or...
The population of adults with congenital heart disease (ACHD) is growing and ageing. Limited information about the diagnostic spectrum this emerging population, its resource utilization at tertiary ACHD centres, especially prognostic parameters available. Retrospective cohort study on all patients ≥60 years age under active follow-up. All-cause mortality was primary outcome measure. Out a total 7315 patients, 375 [190 females (50.7%), mean 64.8 ± 5.9 years] fulfilled inclusion criteria....
To assess the utility of machine learning algorithms on estimating prognosis and guiding therapy in a large cohort patients with adult congenital heart disease (ACHD) or pulmonary hypertension at single, tertiary centre. We included 10 019 (age 36.3 ± 17.3 years) under follow-up our institution between 2000 2018. Clinical demographic data, ECG parameters, cardiopulmonary exercise testing, selected laboratory markers where collected deep (DL) algorithms. Specific DL-models were built based...
Background— Limited data exist with which to stratify risk in adult congenital heart disease (ACHD). An increased ventilatory response exercise, expressed as ventilation per unit of carbon dioxide production (V̇ e /V̇ co 2 slope), is an established predictor impaired survival acquired disease. We sought establish the distribution, relation cyanosis, and prognostic value V̇ slope across a wide spectrum ACHD patients. Methods Results— Five hundred sixty patients varying diagnoses 50 healthy...
The New York Heart Association functional classification (NYHA class) is often used to describe the capacity of adults with congenital heart disease (ACHD), albeit limited evidence on its validity in this heterogeneous population. We aimed validate NYHA ACHD by examining relation objective measures limitation using cardiopulmonary exercise testing (CPET) and mortality.This study included all patients who underwent a CPET between 2005 2015 at Royal Brompton, whom was graded according...
Background: Pulmonary valve replacement (PVR) in patients with repaired tetralogy of Fallot provides symptomatic benefit and right ventricular (RV) volume reduction. However, data on the rate structural functional adaptation are scarce. We aimed to assess immediate midterm post-PVR changes predictors reverse remoeling. Methods: Fifty-seven (age ≥16 y; mean age, 35.8±10.1 38 male) undergoing PVR were prospectively recruited for cardiovascular magnetic resonance performed before (pPVR),...
The post-approval MELODY Registry aimed to obtain multicentre registry data after transcatheter pulmonary valve implantation (TPVI) with the Melody™ (Medtronic plc.) in a large-scale cohort of patients congenital heart disease (CHD).Retrospective analysis TPVI valve. Eight hundred and forty-five (mean age: 21.0 ± 11.1 years) underwent 42 centres between December 2006 September 2013 were followed-up for median 5.9 years (range: 0-11.0 years). composite endpoint TPVI-related events during...
This study sought to identify patients with repaired tetralogy of Fallot (rTOF) at high risk death and malignant ventricular arrhythmia (VA).To date there is no robust stratification scheme predict outcomes in adults rTOF.Consecutive were prospectively recruited for late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) define right left (RV, LV) fibrosis addition proven markers.The primary endpoint was all-cause mortality. Of the 550 (median age 32 years, 56% male), 27...
Abstract T1 relaxation time quantification on parametric maps is routinely used in cardiac imaging and may serve as a non-invasive biomarker for diffuse liver disease. In this study, we aimed to investigate the relationship between values function patients with congenital heart disease (CHD) compared biventricular circulation (BVC) those Fontan (FC). Magnetic resonance images from CHD, obtained June December 2023 1.5 T machine, were retrospectively reviewed. The examinations included cine...
Background— Patients after repair of tetralogy Fallot (ToF) frequently have right ventricular (RV) dysfunction and prolonged QRS duration (QRSd) thus could be candidates for cardiac resynchronization therapy. We aimed to assess the relationship between QRSd timing RV wall motion, including outflow tract (RVOT), in these patients. Methods Results— Sixty-seven repaired ToF patients (median age, 34 years; interquartile range, 24 43 years) 35 age-matched control subjects were studied by...
<h3>Objective</h3> To assess the relationship between elevated levels of B-type natriuretic peptide (BNP) and outcome in patients with Eisenmenger syndrome. <h3>Design</h3> Retrospective study. <h3>Setting</h3> Tertiary centre for adult congenital heart disease. <h3>Patients</h3> All syndrome (n=181, age 36.9±12.1 years, 31% Down syndrome) whom BNP concentrations were measured as part routine clinical care included. <h3>Main measures</h3> The study end point was all cause mortality....
Repaired tetralogy of Fallot (rtoF) patients are at risk atrial or ventricular tachyarrhythmia and sudden cardiac death. Risk stratification for arrhythmia remains difficult. We investigated whether anatomy function predict arrhythmia.One-hundred-and-fifty-four adults with rtoF, median age 30.8 (21.9-40.2) years, were studied a standardised protocol including cardiovascular magnetic resonance (CMR) prospectively followed up over 5.6 (4.6-7.0) years the pre-specified endpoints new-onset...
Infective endocarditis (IE) is associated with significant morbidity and mortality. Patients adult congenital heart disease (ACHD) have an increased risk of developing IE. The aim this study to describe the incidence, predictors outcome mortality IE in ACHD a contemporary cohort.All episodes adults referred our tertiary centre between 1999 2013 were included study. identified from hospital database. diagnosis was established according modified Duke criteria. primary endpoint...
Abstract Aims To investigate the utility of novel deep learning (DL) algorithms in recognizing transposition great arteries (TGA) after atrial switch procedure or congenitally corrected TGA (ccTGA) based on routine transthoracic echocardiograms. In addition, ability DL for delineation and segmentation systemic ventricle was evaluated. Methods results total, 132 patients (92 40 with ccTGA; 60% male, age 38.3 ± 12.1 years) 67 normal controls (57% 48.5 17.9 examinations were included....