A5100318345- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiovascular Issues in Pregnancy
- Cardiovascular Function and Risk Factors
- Coronary Artery Anomalies
- Cardiac pacing and defibrillation studies
- Pregnancy and preeclampsia studies
- Cardiovascular Health and Risk Factors
- Blood Pressure and Hypertension Studies
- Cardiovascular and Diving-Related Complications
- Cardiovascular Effects of Exercise
- Gestational Diabetes Research and Management
- Renal and Vascular Pathologies
- Heart Failure Treatment and Management
- Cardiovascular Conditions and Treatments
- Hemodynamic Monitoring and Therapy
- Aortic Disease and Treatment Approaches
- Vascular anomalies and interventions
- Cardiac Arrest and Resuscitation
- Congenital Diaphragmatic Hernia Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Infective Endocarditis Diagnosis and Management
Fu Wai Hospital
2020-2025
State Key Laboratory of Cardiovascular Disease
2025
Royal Brompton Hospital
2015-2024
Imperial College London
2013-2024
Guy's and St Thomas' NHS Foundation Trust
2021-2024
Weifang People's Hospital
2024
Guiyang Medical University
2024
Affiliated Hospital of Guizhou Medical University
2024
Harefield Hospital
2022-2023
Royal Brompton & Harefield NHS Foundation Trust
2007-2022
Background— Although some patients with adult congenital heart disease (ACHD) report limitations in exercise capacity, we hypothesized that depressed capacity may be more widespread than superficially evident during clinical consultation and could a means of assessing risk. Methods Results— Cardiopulmonary testing was performed 335 consecutive ACHD (age, 33±13 years), 40 non–congenital failure 58±15 11 young 29±5 years) 12 older 59±9 healthy subjects. Peak oxygen consumption (peak V̇ o 2 )...
Background— Late morbidity and mortality remain problematic after repair of tetralogy Fallot (TOF). We hypothesized that fibrosis detected by late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) would be present in adults with repaired TOF related to adverse markers outcome. Method Results— LGE was scored the right left ventricles (RV LV) 92 adult patients who had undergone repair. RV seen all at surgical sites located outflow tract (99%) or site ventricular septal...
Adult congenital heart disease (ACHD) patients have ongoing morbidity and reduced long-term survival. Recently, the importance of specialized follow-up at tertiary ACHD centers has been highlighted. We aimed to assess survival prospects clarify causes death in a large cohort single, center.We included 6969 adult (age 29.9 ± 15.4 years) under our institution between 1991 2013. Causes were ascertained from official certificates. Survival was compared with expected general age- sex-matched...
Background — Neurohormonal activation characterizes chronic heart failure, relates to outcome, and is a therapeutic target. It not known whether similar pattern of neurohormonal exists in adults with congenital disease and, if so, it common measures severity or cardiac anatomy better discriminant. Methods Results Concentrations atrial natriuretic peptide (ANP), brain (BNP), endothelin-1 (ET-1), renin, aldosterone, norepinephrine, epinephrine were determined 53 disease, comprising 4 distinct...
Background— Sudden cardiac death and life-threatening ventricular arrhythmia remain a concern in adult patients with repaired tetralogy of Fallot. Longitudinal left (LV) function is sensitive detecting early myocardial damage may have prognostic implications this setting. Methods Results— We included 413 Fallot (age, 36±13 years; QRS duration, 148±27 milliseconds; LV ejection fraction, 55±10%). A composite end point sudden death/life-threatening (sustained tachycardia, resuscitated death, or...
Background— Limited data exist with which to stratify risk in adult congenital heart disease (ACHD). An increased ventilatory response exercise, expressed as ventilation per unit of carbon dioxide production (V̇ e /V̇ co 2 slope), is an established predictor impaired survival acquired disease. We sought establish the distribution, relation cyanosis, and prognostic value V̇ slope across a wide spectrum ACHD patients. Methods Results— Five hundred sixty patients varying diagnoses 50 healthy...
Indications for surgical pulmonary valve replacement (PVR) after repair of tetralogy Fallot have recently been broadened to include asymptomatic patients.The outcomes PVR in adults at a single tertiary center were retrospectively studied. Preoperative cardiopulmonary exercise testing was included. Mortality the primary outcome measure. In total, 221 PVRs performed 220 patients (130 male patients; median age, 32 years; range, 16-64 years). Homografts used 117 patients, xenografts 103 and...
Background— Eisenmenger syndrome differs significantly from other types of pulmonary arterial hypertension in its physiology and prognosis. We sought to assess the relationship between echocardiographic characteristics patients with mortality. Methods Results— Clinical variables were assessed 181 consecutive syndrome, excluding those complex congenital heart disease. Patients' mean age was 39.1±12.8 years, 59 (32.6%) male, 122 (67.4%) functional class III or higher, 74 (40.9%) on advanced...
Background: Pulmonary valve replacement (PVR) in patients with repaired tetralogy of Fallot provides symptomatic benefit and right ventricular (RV) volume reduction. However, data on the rate structural functional adaptation are scarce. We aimed to assess immediate midterm post-PVR changes predictors reverse remoeling. Methods: Fifty-seven (age ≥16 y; mean age, 35.8±10.1 38 male) undergoing PVR were prospectively recruited for cardiovascular magnetic resonance performed before (pPVR),...
Background— Patients after repair of tetralogy Fallot (ToF) frequently have right ventricular (RV) dysfunction and prolonged QRS duration (QRSd) thus could be candidates for cardiac resynchronization therapy. We aimed to assess the relationship between QRSd timing RV wall motion, including outflow tract (RVOT), in these patients. Methods Results— Sixty-seven repaired ToF patients (median age, 34 years; interquartile range, 24 43 years) 35 age-matched control subjects were studied by...
Abstract Aims To investigate the utility of novel deep learning (DL) algorithms in recognizing transposition great arteries (TGA) after atrial switch procedure or congenitally corrected TGA (ccTGA) based on routine transthoracic echocardiograms. In addition, ability DL for delineation and segmentation systemic ventricle was evaluated. Methods results total, 132 patients (92 40 with ccTGA; 60% male, age 38.3 ± 12.1 years) 67 normal controls (57% 48.5 17.9 examinations were included....
Abstract Background and Objective Pulmonary hypertension is a life‐limiting complication of interstitial lung disease (ILD‐PH). We investigated whether treatment with phosphodiesterase 5 inhibitors (PDE5i) in patients ILD‐PH was associated improved survival. Methods Consecutive incident right heart catheterisation, echocardiography spirometry data were followed from diagnosis to death, transplantation or censoring all follow‐up survival modelled by Bayesian methods. Results The diagnoses 128...
Mustard repair for transposition of the great arteries (TGA) is frequently associated with impaired systemic (right) ventricular function and sometimes exercise intolerance. We hypothesized that a simple quantitative measurement function, during rest pharmacological stress, could identify abnormalities predict objective capacity.We quantified performance pulmonary (left) ventricles by using echocardiography, at dobutamine in 27 adults who had undergone TGA. Systolic diastolic ventricle were...
In patients with acquired heart failure, hypoalbuminaemia is associated increased risk of death. The prevalence hypoproteinaemia and their relation to outcome in adult congenital disease (ACHD) remains, however, unknown.Data on ACHD who underwent blood testing our centre within the last 14 years were collected. between laboratory, clinical or demographic parameters at baseline mortality was assessed using Cox proportional hazards regression analysis.A total 2886 included. Mean age 33.3...