A5070708677- Peripheral Artery Disease Management
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Arrhythmias and Treatments
- Heart Failure Treatment and Management
- Renal and Vascular Pathologies
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Vascular Procedures and Complications
- Chronic Kidney Disease and Diabetes
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Kidney Injury Research
- Transplantation: Methods and Outcomes
- Infective Endocarditis Diagnosis and Management
- Aortic aneurysm repair treatments
- Health and Medical Studies
- Diabetic Foot Ulcer Assessment and Management
- Blood Pressure and Hypertension Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Structural Anomalies and Repair
University Hospital Münster
2016-2025
University of Münster
2007-2023
Universitätsmedizin Greifswald
2019-2022
Weatherford College
2022
University of Oxford
2022
Harvard University
2022
Massachusetts General Hospital
2022
John Radcliffe Hospital
2022
Klinik für Schlafmedizin
2010-2021
Ärztliche Gesellschaft zur Gesundheitsförderung e.V
2018
The current manuscript is the second update of original Practical Guide, published in 2013 [Heidbuchel et al. European Heart Rhythm Association Guide on use new oral anticoagulants patients with non-valvular atrial fibrillation. Europace 2013;15:625-651; Heidbuchel Updated non-vitamin K antagonist 2015;17:1467-1507]. Non-vitamin (NOACs) are an alternative for vitamin antagonists (VKAs) to prevent stroke fibrillation (AF) and have emerged as preferred choice, particularly newly started...
CV Cardiovascular CYP Cytochrome P (CYP) Unfractionated heparin ULN Upper limit of normal VENTURE-AF Active-controlled multi-center study with blind-adjudication designed to evaluate the safety uninterrupted Rivaroxaban and vitamin K antagonists in subjects undergoing catheter ablation for non-valvular Atrial Fibrillation VHD Valvular heart disease VKA Vitamin antagonist VTE Venous thromboembolic event WOEST What is Optimal antiplatelet anticoagulant therapy patients oral anticoagulation...
Only few and historic studies reported a bad prognosis of peripheral arterial disease (PAD) critical limb ischaemia (CLI). The contemporary state treatment outcomes should be assessed. From the largest public health insurance in Germany, all in- outpatient diagnosis procedural data were retrospectively obtained from cohort 41 882 patients hospitalized due to PAD during 2009–2011, including follow-up until 2013. Patients classified Rutherford categories 1–3 (n = 21 197), 4 5353), 5 6916), 6...
eCrCl (mL/min) a Warfarin Apixaban b Dabigatran Edoxaban c Rivaroxaban >95 Adjusted dose (INR 2-3) 5 mg b.i.d.150 b.i.d.60 QD d 20 51-95 31-50 b.i.d.(eCrCl cut-off 25 mL/min) 150 b.i.d. or 110 e 30 15 INR, international normalized ratio.a Cockcroft-Gault estimated creatinine clearance (eCrCl).b modification from to 2.5 b.i.d.if patient has any two of the following: serum > _1.5 mg/dL, age _80 years, body weight < _60 kg.c In ENGAGE-AF TIMI 48 study, was halved if 30-50 mL/min, kg,...
Since the adoption of transcatheter aortic-valve replacement (TAVR), questions have been raised about its effect on clinical practice in comparison with surgical replacement, which is considered current standard care. Complete nationwide data are useful examining how introduction a new technique influences previous standards.We analyzed characteristics patients and in-hospital outcomes for all isolated TAVR procedures performed Germany from 2007 to 2013.In total, 32,581 55,992 were...
Abstract Aims Drug-eluting devices (DED) represent a well-established therapy being widely used for endovascular revascularization (EVR) of peripheral vessels. Recent data indicate two-fold increased long-term mortality in patients treated with paclitaxel-based DED. The subsequent safety concerns affected international regulatory authorities to enunciate several alerts further application Methods and results In 9.2 million insurants the German BARMER Health Insurance, on drug-eluting stents...
Background: Non–vitamin K oral anticoagulants have become the standard therapy for preventing stroke and ischemic thromboembolism in most patients with atrial fibrillation (AF). The effectiveness safety of non–vitamin on hemodialysis is not well known. Methods: From June 2017 through May 2022, AXADIA–AFNET 8 (Compare Apixaban Vitamin Antagonists Patients With Atrial Fibrillation End-Stage Kidney Disease), an investigator-initiated PROBE (prospective randomized open blinded end point) outcome...
Abstract —Plasma concentration of markers inflammation are increased in patients with atherosclerosis. However, it is unclear whether the pattern and magnitude this increase vary site extent disease. In 147 undergoing semiquantitative coronary angiography, we measured acute-phase reactants C-reactive protein (CRP) or serum amyloid A (SAA); proinflammatory cytokine interleukin 6 (IL-6); active total fractions anti-inflammatory transforming growth factor-β (TGF-β); macrophage activation marker...
Symmetrical dimethylarginine (SDMA) is the structural isomer of endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine. Whereas major route elimination hydrolytic degradation by dimethylaminohydrolase, SDMA eliminated renal excretion. does not directly inhibit NOS but a competitor arginine transport. This study showed for first time that measurement can be marker estimated GFR and extent coronary artery disease (CAD). In 97 patients with CAD, was GFR. On multiple...
AimsThe prevalence of peripheral arterial disease (PAD) and especially critical limb ischaemia (CLI) is announced to rise dramatically worldwide, with a considerable impact on the health care socio-economic systems. We aimed characterize recent trends in morbidity in-hospital outcome PAD among all hospitalized patients entire German population between 2005 2009.
The aim of this study was to analyze the pacemaker implantation rate (PMIR) with new balloon-expandable Edwards SAPIEN 3 valve (S3) and factors associated it.The introduction S3 for transcatheter aortic replacement (TAVR) has led a reduction in paravalvular regurgitation. There are, however, concerns that design may increase PMIR.The first 206 patients treated were compared 371 preceding XT valves. Patients who previously underwent or implantable cardioverter defibrillator transapical...
Risks of catheter ablation for atrial fibrillation and flutter assessed in retrospective studies, registries, controlled trials may underestimate 'real world' conditions.
Recent guidelines on acute myocardial infarction (AMI) are based randomized clinical trials (RCTs) and registries with selected patients, may therefore not represent 'real-life'. This analysis shows for the first time nationwide trends in AMI from Germany.We were provided data all in-patient hospitalizations by Federal Statistical Office. All hospitalized cases (onset of symptoms <28 days) years 2005, 2007, 2009 analysed regarding morbidity, in-hospital mortality, treatments, costs. Analysis...
Background: Declining amputation rates have been reported in multiple countries recent years.It is not yet known whether declined Germany as well.Methods: On the basis of DRG (diagnosis-related group) data, we received a list from German Federal Statistical Office all major and minor amputations documented hospitals 2005 to 2014.Changes over this period were studied with linear regression.Results: The absolute number per year rose slightly 55 689 57 637 (+3.5%) 2014.After exclusion cases...
Heterozygous truncating variants in TTN (TTNtv), the gene coding for titin, cause dilated cardiomyopathy (DCM), but underlying pathomechanisms are unclear and disease management remains uncertain. Truncated titin proteins have not yet been considered as a contributor to development. Here, we studied myocardial tissues from nonfailing donor hearts 113 patients with end-stage DCM expression identified TTNtv 22 (19.5%). We directly demonstrate haploinsufficiency TTNtv-DCM absence of...
Background: The global rise of obesity and its association with cardiovascular risk factors (CVRF) have highlighted connection to chronic heart failure (CHF). Paradoxically, obese CHF patients often experience better outcomes, a phenomenon known as the ‘obesity paradox’. This study evaluated paradox’ within large cohort in Germany explored how varying degrees affect HF outcome. Methods: Anonymized health claims data from largest German insurer (AOK) for years 2014–2015 were utilized analyze...