A5064739825- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Issues in Pregnancy
- Cardiac Arrhythmias and Treatments
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Coronary Artery Anomalies
- Cardiovascular Function and Risk Factors
- Renal and Vascular Pathologies
- Transplantation: Methods and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- COVID-19 and healthcare impacts
- Heart Failure Treatment and Management
- Cardiovascular Health and Disease Prevention
- Aortic Disease and Treatment Approaches
- Cardiac Imaging and Diagnostics
- Liver Disease and Transplantation
- Neuroscience of respiration and sleep
- Acute Ischemic Stroke Management
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular Disease and Adiposity
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
Rigshospitalet
2016-2025
Copenhagen University Hospital
2015-2025
University of Copenhagen
2010-2024
ERN GUARD-Heart
2023
Slagelse Hospital
2018
Lung Institute
2015-2017
Imperial College London
2015-2017
Royal Brompton Hospital
2016-2017
Capital Medical University
2016
Beijing Anzhen Hospital
2016
The Fontan procedure has improved survival in children with functionally univentricular hearts. With time, however, complications such as reduced exercise capacity are seen more frequently. Exercise intolerance is multifactorial, but pulmonary vascular resistance probably plays a crucial role. Elevated been associated raised levels of endothelin-1, which common both before and after operations. Treatment endothelin-1 receptor antagonists could theoretically improve cardiopulmonary...
AimsTo evaluate the efficacy of combining dual endothelin receptor antagonist, bosentan, and phosfodiesterase-5-inhibitor, sildenafil, in patients with Eisenmenger syndrome.
Eisenmenger syndrome is associated with substantial morbidity and mortality. There no consensus, however, on mortality risk stratification. We aimed to investigate survival predictors of death in a large, contemporary cohort patients.In multicenter approach, we identified adults under follow-up between 2000 2015. examined its association clinical, electrocardiographic, echocardiographic, laboratory parameters.We studied 1098 patients (median age, 34.4 years; range, 16.1-84.4 65.1% female;...
Background— End-stage heart failure is associated with impaired cardiac output (CO) and organ blood flow. We determined whether CO peripheral perfusion are maintained during exercise in patients an axial-flow left ventricular assist device (LVAD) increase LVAD pump speed work rate would Methods Results— Invasively leg flow Doppler-determined cerebral were measured 2 incremental cycle tests on the same day 8 provided a HeartMate II LVAD. In random order, exercised both constant (≈9775 rpm)...
Eisenmenger syndrome (ES) is associated with considerable morbidity and mortality. Therapeutic strategies have changed during the 2000s in conjunction an emphasis on specialist follow-up. The aim of this study was to determine cause-specific mortality ES evaluate any relevant changes between 1977 2015.This a retrospective, descriptive multicentre study. A total 1546 patients (mean age 38.7 ± 15.4 years; 36% male) from 13 countries were included. Cause-specific examined before after July...
Patients with cyanotic congenital heart disease (CCHD) have a high prevalence of thrombosis, the most frequently described locations being cerebral and pulmonary vessels. The reported both infarction thrombosis has been highly variable. aim this study was to examine in CCHD according medical history imaging. In addition, role known erythrocytosis haemostatic abnormalities as risk factors evaluated.A cross-sectional descriptive examining 98 stable adult patients questionnaire, blood samples,...
Patients with adult congenital heart disease (ACHD) are a potentially vulnerable patient cohort in case of COVID-19. Some cardiac defects may be associated poor COVID-19 outcome. Risk estimation ACHD is currently based on expert opinion. The aim this study was to collect clinical outcome data and identify risk factors for complicated course patients ACHD.Twenty-five centres nine European countries participated the study. Consecutive diagnosed presenting one participating between 27 March 6...
To assess spectrophotometric oximetry across a broad range of arterial saturation levels and to study the effect chronic systemic hypoxemia on retinal oxygen extraction.The included 16 patients with Eisenmenger syndrome, cyanotic cardiac defect, 17 healthy volunteers. Oxygen in selected major arteries veins was assessed using noninvasive oximetry. Arterial blood gases were determined within 1 day ophthalmic examination samples from femoral artery.The 81% ± 9% (mean SD) syndrome subnormal...
Abstract Aims The decisions about placing an ICD in a child are more difficult than adult due to longer expected lifespan and the complication risk. Young patients gain most years from ICDs, despite higher risk of device-related complications. secondary prevention indication is clear, device implanted regardless potential For primary prevention, sudden cardiac death complications need be evaluated. We aimed compare outcomes for ICDs. Methods results Retrospective nationwide cohort study...
Background— Patients with Eisenmenger syndrome (ES) have better survival, despite similar pulmonary vascular pathology, compared other patients arterial hypertension. Cardiovascular magnetic resonance (CMR) is useful for risk stratification in idiopathic hypertension, whereas it has not been evaluated ES. We studied CMR together noninvasive measurements ES to evaluate its potential role as a test. Methods and Results— Between 2003 2005, 48 ES, all post-tricuspid shunt, were enrolled...
Abstract Background and Aims Pacemaker therapy is a lifesaving treatment in children with advanced atrioventricular blocks. However, there concern regarding pacemaker-induced cardiomyopathy (PICM). Currently, lack of data comparing the incidence PICM congenital complete block (cc-AVB) to postoperative (po-AVB). We aimed delineate these groups. Methods This retrospective study included all ≤15 years who received pacemakers for either cc-AVB or po-AVB between 1982 2021 Denmark. Patients were...
<h3>Objective</h3> Improved diagnostic tools, timely closure of the shunt and a better understanding complexity Eisenmenger syndrome (ES) have led to improved care treatment in tertiary centres. These may decreased incidence ES survival patients with ES, although evidence is still lacking. The aim this study was investigate temporal changes incidence, prevalence mortality for 35 years Nordic region. <h3>Methods</h3> This retrospective population-based including 714 ES. Survival analysis...
The optimal timing for transplantation is unclear in patients with Eisenmenger syndrome (ES). We investigated post-transplantation survival and transplantation-specific morbidity after heart-lung (HLTx) or lung (LTx) a cohort of Nordic ES to aid decision-making scheduling transplantation.We performed retrospective, descriptive, population-based study who underwent from 1985 2012.Among 714 the region, 63 (9%) transplantation. median age at was 31.9 (IQR 21.1-42.3) years. Within 30 days...