A5082025334- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- High Altitude and Hypoxia
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- COVID-19 and healthcare impacts
- Cardiovascular Issues in Pregnancy
- Cardiovascular Function and Risk Factors
- Aortic Disease and Treatment Approaches
- Acute Myocardial Infarction Research
- Kawasaki Disease and Coronary Complications
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Migration, Racism, and Human Rights
- Lung Cancer Treatments and Mutations
- Polysaccharides Composition and Applications
- Lipoproteins and Cardiovascular Health
Vall d'Hebron Hospital Universitari
2015-2025
Universitat Autònoma de Barcelona
2015-2025
Centro de Investigación en Red en Enfermedades Cardiovasculares
2018-2025
Centro de Investigación Biomédica en Red
2019-2025
Instituto de Salud Carlos III
2024-2025
ERN GUARD-Heart
2024-2025
Vall d'Hebron Institut de Recerca
2019-2025
Universidade de Brasília
2024
Adult Congenital Heart Association
2023
Patients with adult congenital heart disease (ACHD) are a potentially vulnerable patient cohort in case of COVID-19. Some cardiac defects may be associated poor COVID-19 outcome. Risk estimation ACHD is currently based on expert opinion. The aim this study was to collect clinical outcome data and identify risk factors for complicated course patients ACHD.Twenty-five centres nine European countries participated the study. Consecutive diagnosed presenting one participating between 27 March 6...
Abstract This study explores parallels between systemic hypoxia adaptation in high-altitude populations and tumorigenesis. We identified EPAS1, a gene critical for such as Tibetans Sherpas, playing similar adaptive role tumors arising under hypoxic conditions. Tumors from patients with chronic displayed impaired DNA repair frequent emergence of EPAS1 variants, frequencies reaching up to 90%, echoing the positive selection seen dwellers. Mechanistically, gain-of-function mutations promote...
Information on mid-term outcomes of percutaneous pulmonary valve replacement (PPVR) with the Edwards Sapien (ES) in native right ventricular outflow tract (RVOT) are limited. This study assesses 76 patients who underwent PPVR between 2016 and 2022, comparing (40.8%) non-native (59.2%) RVOTs. The primary endpoint was a composite endocarditis, reinterventions, cardiovascular death secondary included prosthetic dysfunction (PVD), tricuspid regurgitation (TR), ejection fraction (RVEF), indexed...
<div>Abstract<p>This study explores parallels between systemic hypoxia adaptation in high-altitude populations and tumorigenesis. We identified <i>EPAS1</i>, a gene critical for such as Tibetans Sherpas, playing similar adaptive role tumors arising under hypoxic conditions. Tumors from patients with chronic displayed impaired DNA repair frequent emergence of <i>EPAS1</i> variants, frequencies reaching up to 90%, echoing the positive selection seen...
<p>Supplementary Figure S1. Description of the CCHD-PPGL cohort 27 individuals with CCHD who developed 38 PPGL tumors. Supplementary S2. Summary clinical features patients CCHD-PPGL. S3. EPAS1 mutations are enriched in hypoxic (88.8%) compared to normoxic without (4.5%). S4. clonality tumor samples from TCGA(1–4) (patients conditions). S5. No were detected carotid body PGL S6. Hierarchical cluster analysis RNA sequencing data EPAS1-mutated S7. Convergent Evolution Natural Populations...
<p>Supplementary Figure S1. Description of the CCHD-PPGL cohort 27 individuals with CCHD who developed 38 PPGL tumors. Supplementary S2. Summary clinical features patients CCHD-PPGL. S3. EPAS1 mutations are enriched in hypoxic (88.8%) compared to normoxic without (4.5%). S4. clonality tumor samples from TCGA(1–4) (patients conditions). S5. No were detected carotid body PGL S6. Hierarchical cluster analysis RNA sequencing data EPAS1-mutated S7. Convergent Evolution Natural Populations...
Intra-atrial re-entrant tachycardia (IART) is a frequent and severe complication in patients with congenital heart disease (CHD). Cavotricuspid isthmus (CTI)-related IART the most mechanism. However, due to fibrosis surgical scars, non-CTI-related also frequent. The main objective of this study was describe types circuit locations define cut-off value for unhealthy tissue atria. This observational included all consecutive CHD who underwent first ablation procedure from January 2009 December...
Introduction: Bilirubin may elicit cardiovascular protection and heme oxygenase-1 overexpression attenuated post-infarction ventricular remodeling in experimental animals, but the association between bilirubin levels is unknown.Materials methods: In 145 patients with a first anterior ST-segment elevation acute myocardial infarction (STEMI), we assessed whether plasma on admission predicted adverse (left end-diastolic volume [LVEDV] increase ≥20% discharge 6 months, estimated by magnetic...
Intra-atrial re-entrant tachycardia (IART) is a common complication in patients with congenital heart disease (CHD) and related to increased morbidity mortality. Few reports have been published about factors associated IART severity. The aim of this study analyse severe clinical presentation IART. Observational all consecutive CHD who underwent first ablation from January 2009 December 2015 (94 patients, 39.4% female, age: 36.55 ± 14.9 years). Severe was defined as failure, syncope, shock,...
Background There is little information of progestogen-only contraceptives in patients with congenital heart disease (CHD) on the long-term.
Abstract EPAS1 HIF2α is the primary gene implicated in systemic hypoxia adaptation. Conversely, aberrantly activated acts as a tumor driver against which anti-tumor therapeutics are proven effective. We elucidated connections between adaptation to high-altitude populations, such Tibetans and Sherpas, human tumors. Similar accelerated adaptability observed populations via genetic introgression, tumors from patients with since birth exhibited impaired DNA repair increased mutation burden. As...
Abstract Background Aortic coarctation is a major risk factor for high blood pressure and atherosclerotic disease development. Evidence lacking regarding the treatment of acute coronary syndrome in patients with untreated aortic coarctation. Case summary A 50-year-old male history hypertension, diabetes, haemodynamically significant presented to emergency department non-ST-elevation myocardial infarction. Coronary catheterization showed severe three-vessel disease. The was addressed...
To describe the aortic-related risks associated with pregnancy in women bicuspid aortic valve (BAV) and to evaluate changes diameter pregnancy.