A5032217545- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Cardiovascular Function and Risk Factors
- Connective tissue disorders research
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Advanced MRI Techniques and Applications
- Infective Endocarditis Diagnosis and Management
- Cardiomyopathy and Myosin Studies
- Aortic Thrombus and Embolism
- Cardiovascular Issues in Pregnancy
- Cerebrovascular and Carotid Artery Diseases
- Renal and Vascular Pathologies
- Atrial Fibrillation Management and Outcomes
- Coronary Artery Anomalies
- Trauma Management and Diagnosis
- Pulmonary Hypertension Research and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Effects of Exercise
- Williams Syndrome Research
- Coronary Interventions and Diagnostics
Vall d'Hebron Institut de Recerca
2014-2025
Universitat Autònoma de Barcelona
2016-2025
Vall d'Hebron Hospital Universitari
2016-2025
Centro de Investigación en Red en Enfermedades Cardiovasculares
2017-2025
Hebron University
2024-2025
Instituto de Salud Carlos III
2021-2025
Centro de Investigación Biomédica en Red
2019-2025
Hospital Universitario Fundación Jiménez Díaz
2024
Centre for Biomedical Network Research on Rare Diseases
2022
VASCERN
2019
In patients with bicuspid valve (BAV), ascending aorta (AAo) dilatation may be caused by altered flow patterns and wall shear stress (WSS). These differences explain different aortic morphotypes. Using 4D-flow cardiovascular magnetic resonance (CMR), we aimed to analyze in regional axial circumferential WSS maps between BAV phenotypes their correlation morphotype. One hundred one (aortic diameter ≤ 45 mm, no severe valvular disease) 20 healthy subjects were studied CMR. Peak velocity, jet...
To determine the efficacy of losartan vs. atenolol in aortic dilation progression Marfan syndrome (MFS) patients.A phase IIIb, randomized, parallel, double-blind study was conducted 140 MFS patients, age range: 5-60 years, with maximum diameter <45 mm who received (n = 70) or 70). Doses were raised to a 1.4 mg/kg/day 100 mg/day. The primary end-point change root and ascending aorta indexed by body surface area on magnetic resonance imaging after 36 months treatment. No serious drug-related...
Purpose To determine the normal size and wall thickness of ascending thoracic aorta (AA) its relationship with cardiovascular risk factors in a large population‐based study. Materials Methods The mean AA luminal diameter was measured 3573 Multi‐Ethnic Study Atherosclerosis (MESA) participants (age: 45–84 years), using gradient echo phase contrast cine MRI. Multiple linear regression models were used to evaluate associations between diameter. median upper limit (95th percentile) defined...
This study sought to assess cross-sectional associations of aortic stiffness assessed by magnetic resonance imaging with left ventricular (LV) remodeling and myocardial deformation in the Multi-Ethnic Study Atherosclerosis (MESA).Aortic arch pulse wave velocity (PWV) was measured phase contrast cine imaging. LV circumferential strain (Ecc), torsion, early diastolic rate were determined tagged Multivariable linear regression models used adjust for demographics cardiovascular risk factors. Of...
Abstract Aims Life expectancy in Marfan syndrome patients has improved thanks to the early detection of aortic dilation and prophylactic root surgery. Current international clinical guidelines support use diameter as a predictor complications. However, other imaging markers are needed improve risk stratification. This study aim ascertain whether proximal aorta longitudinal circumferential strain distensibility assessed by cardiac magnetic resonance (CMR) predict rate events syndrome. Methods...
<h3>Background</h3> The effect of <i>FBN1</i> mutation type on the severity cardiovascular manifestations in patients with Marfan syndrome (MFS) has been reported disparity results. <h3>Objectives</h3> This study aims to determine impact aortic diameters, dilation rates and events (ie, dissection mortality). <h3>Methods</h3> MFS a pathogenic followed at two specialised units were included. mutations classified as being dominant negative (DN; incorporation non-mutated mutated fibrillin-1...
Objective Bicuspid aortic valve (BAV) is associated with early valvular dysfunction and proximal aorta dilation high heterogeneity. This study aimed to assess the determinants of these complications. Methods Eight hundred fifty-two consecutive adults diagnosed BAV referred from cardiac outpatient clinics eight echocardiographic laboratories tertiary hospitals were prospectively recruited. Exclusion criteria coarctation, other congenital disorders or intervention. morphotype, significant (≥2...
The predictive value of aortic arch pulse wave velocity (PWV) assessed by magnetic resonance imaging for cardiovascular disease (CVD) events has not been fully established. aim the present study was to evaluate association PWV with incident CVD in MESA (Multi-Ethnic Study Atherosclerosis). Aortic measured using at baseline 3527 participants (mean age, 62±10 years baseline; 47% men) free overt CVD. Cox regression used risk (coronary heart disease, stroke, transient ischemic attack, or...
Objective Bicuspid aortic valve (BAV) is the most common congenital heart disease. This study aimed to determine prevalence rate of BAV in first-degree relatives (FDR) and inheritance pattern according different morphotypes dilation. Methods probands were consecutively studied at eight tertiary referral centres. After sequential screening, FDR included study. The morphotype, dilation phenotype assessed by transthoracic echocardiography. Results Seven hundred twenty-four 256 agreed undergo...
The study was performed to determine age, sex, and time-dependent changes in aortic wall thickness (AWT) evaluate cross-sectional associations between AWT arterial stiffness older adults. Three hundred seventy-one longitudinal 426 measurements of from cardiovascular magnetic resonance imaging studies conducted within the Multi-Ethnic Study Atherosclerosis were analyzed at 2 points time, 2000 2002 then again follow-up examinations 2010 2012. Aortic determined a double inversion recovery...
Abstract Aims Aortic dilation in bicuspid aortic valve (BAV) might extend to the proximal arch. Arch flow dynamics and their relationship with this segment are still unexplored. Using 4D-flow cardiovascular magnetic resonance, we analysed arch for each BAV morphotype association dilation. Methods results One hundred eleven patients (aortic diameters ≤55 mm, non-severe valvular disease), 21 age-matched tricuspid (TAV) dilated 24 healthy volunteers (HV) underwent 4D-flow. were classified per...
Aortic stenosis (AS) is characterized by calcification and fibrosis. The ability to quantify these processes simultaneously has been limited with previous imaging methods. purpose of this study was evaluate the aortic valve fibrocalcific volume computed tomography (CT) angiography in patients AS, particular, assess its reproducibility, association histology disease severity, predict/track progression. In 136 calculated on CT angiograms at baseline after 1 year. attenuation distributions were...
Longitudinal determinants of aortic stiffness (AS) measured by magnetic resonance imaging (MRI) have not been assessed in a large community-based population. Our aim was to examine the change thoracic AS over 10 years follow-up multi-ethnic population individuals 45 age and older MRI. We studied 1160 participants (mean = 60 ± 9 at baseline, 45% male) with MRI both MESA Year 0 examinations. Ascending descending aorta distensibility (AAD/DAD) arch pulse-wave velocity (PWV) were using...
Diseases of the descending aorta have emerged as a clinical issue in Marfan syndrome following improvements proximal surgical treatment and consequent increase life expectancy. Although role for hemodynamic alterations etiology disease patients has been suggested, whether flow characteristics may be useful early markers remains to determined. Seventy-five 48 healthy subjects were prospectively enrolled. In- through-plane vortexes computed by 4D cardiovascular magnetic resonance (CMR)...