A5023436129- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Health Systems, Economic Evaluations, Quality of Life
- Heart Failure Treatment and Management
- Coronary Interventions and Diagnostics
- Statistical Methods in Clinical Trials
- Diabetes Treatment and Management
- Meta-analysis and systematic reviews
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Lipoproteins and Cardiovascular Health
- Pancreatic function and diabetes
- Advanced Causal Inference Techniques
- Venous Thromboembolism Diagnosis and Management
- Metabolism, Diabetes, and Cancer
- Hormonal Regulation and Hypertension
- Acute Ischemic Stroke Management
- Cardiac Valve Diseases and Treatments
- Statistical Methods and Bayesian Inference
- Cardiac, Anesthesia and Surgical Outcomes
- Diabetes Management and Research
- Statistical Methods and Inference
- Cardiac Health and Mental Health
London School of Hygiene & Tropical Medicine
2016-2025
University of London
2015-2025
Spanish National Centre for Cardiovascular Research
2014-2025
NewYork–Presbyterian Hospital
2012-2024
Columbia University Irving Medical Center
2005-2024
Freeman Hospital
2024
Newcastle University
2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2024
United Lincolnshire Hospitals NHS Trust
2024
Northumbria Healthcare NHS Foundation Trust
2024
Much biomedical research is observational. The reporting of such often inadequate, which hampers the assessment its strengths and weaknesses a study's generalisability. Strengthening Reporting Observational Studies in Epidemiology (STROBE) Initiative developed recommendations on what should be included an accurate complete report observational study. We defined scope to cover three main study designs: cohort, case-control, cross-sectional studies. convened 2-day workshop September 2004, with...
Much biomedical research is observational. The reporting of such often inadequate, which hampers the assessment its strengths and weaknesses a study's generalizability. Strengthening Reporting Observational Studies in Epidemiology (STROBE) Initiative developed recommendations on what should be included an accurate complete report observational study. We defined scope to cover 3 main study designs: cohort, case–control, cross-sectional studies. convened 2-day workshop September 2004, with...
Much biomedical research is observational. The reporting of such often inadequate, which hampers the assessment its strengths and weaknesses a study's generalisability. Strengthening Reporting Observational Studies in Epidemiology (STROBE) Initiative developed recommendations on what should be included an accurate complete report observational study. We defined scope to cover three main study designs: cohort, case–control, cross-sectional studies. convened 2-day workshop September 2004, with...
Poor reporting of research hampers assessment and makes it less useful. An international group methodologists, researchers, journal editors sets out guidelines to improve reports observational studies
Many patients with severe aortic stenosis and coexisting conditions are not candidates for surgical replacement of the valve. Recently, transcatheter aortic-valve implantation (TAVI) has been suggested as a less invasive treatment high-risk stenosis.
The cardiovascular effect of liraglutide, a glucagon-like peptide 1 analogue, when added to standard care in patients with type 2 diabetes, remains unknown.In this double-blind trial, we randomly assigned diabetes and high risk receive liraglutide or placebo. primary composite outcome the time-to-event analysis was first occurrence death from causes, nonfatal myocardial infarction, stroke. hypothesis that would be noninferior placebo regard outcome, margin 1.30 for upper boundary 95%...
The use of transcatheter aortic-valve replacement has been shown to reduce mortality among high-risk patients with aortic stenosis who are not candidates for surgical replacement. However, the two procedures have compared in a randomized trial involving still
Much medical research is observational. The reporting of observational studies often insufficient quality. Poor hampers the assessment strengths and weaknesses a study generalisability its results. Taking into account empirical evidence theoretical considerations, group methodologists, researchers, editors developed Strengthening Reporting Observational Studies in Epidemiology (STROBE) recommendations to improve quality studies. STROBE Statement consists checklist 22 items, which relate...
Much medical research is observational. The reporting of observational studies often insufficient quality. Poor hampers the assessment strengths and weaknesses a study generalisability its results. Taking into account empirical evidence theoretical considerations, group methodologists, researchers, editors developed Strengthening Reporting Observational Studies in Epidemiology (STROBE) recommendations to improve quality studies. STROBE Statement consists checklist 22 items, which relate...
Among patients with aortic stenosis who are at intermediate or high risk for death surgery, major outcomes similar transcatheter aortic-valve replacement (TAVR) and surgical replacement. There is insufficient evidence regarding the comparison of two procedures in low risk.
Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of hospitalization for heart failure in patients regardless presence or absence diabetes. More evidence is needed regarding effects these drugs across broad spectrum failure, including those with a markedly reduced ejection fraction.
Sodium–glucose cotransporter 2 inhibitors reduce the risk of hospitalization for heart failure in patients with and a reduced ejection fraction, but their effects preserved fraction are uncertain.
Introduction: The Rationale of Clinical Trials. Historical Development Organization and Planning. Justificaton for Randomized Controlled Methods Randomization. Blinding Placebos. Ethical Issues. Crossover Size a Trial. Monitoring Trial Progress. Forms Data Management. Protocol Deviations. Basic Principles Statistical Analysis. Further Aspects Publication Interpretation Findings. References. Index.
Mineralocorticoid antagonists improve survival among patients with chronic, severe systolic heart failure and after myocardial infarction. We evaluated the effects of eplerenone in chronic mild symptoms.
Much biomedical research is observational. The reporting of such often inadequate, which hampers the assessment its strengths and weaknesses a study's generalisability. Strengthening Reporting Observational Studies in Epidemiology (STROBE) Initiative developed recommendations on what should be included an accurate complete report observational study. We defined scope to cover three main study designs: cohort, case-control, cross-sectional studies. convened 2-day workshop September 2004, with...
In controlled clinical trials there are usually several prognostic factors known or thought to influence the patient's ability respond treatment. Therefore, method of sequential treatment assignment needs be designed so that balance is simultaneously achieved across all such patients factor. Traditional methods restricted randomization as "permuted blocks within strata" prove inadequate once number strata, combinations factor levels, approaches sample size. A new general procedure for...
The CONSORT (Consolidated Standards of Reporting Trials) Statement, which includes a checklist and flow diagram, is guideline developed to help authors improve the reporting findings from randomized controlled trials. It was updated most recently in 2010. Its primary focus on individually trials with 2 parallel groups that assess possible superiority one treatment compared another. Statement has been extended other trial designs such as cluster randomization, recommendations for...
Much medical research is observational. The reporting of observational studies often insufficient quality. Poor hampers the assessment strengths and weaknesses a study generalizability its results. Taking into account empirical evidence theoretical considerations, group methodologists, researchers, editors developed Strengthening Reporting Observational Studies in Epidemiology (STROBE) recommendations to improve quality studies. STROBE Statement consists checklist 22 items, which relate...
Iron deficiency may impair aerobic performance. This study aimed to determine whether treatment with intravenous iron (ferric carboxymaltose) would improve symptoms in patients who had heart failure, reduced left ventricular ejection fraction, and deficiency, either or without anemia.
Treatment with the direct thrombin inhibitor bivalirudin, as compared heparin plus glycoprotein IIb/IIIa inhibitors, results in similar suppression of ischemia while reducing hemorrhagic complications patients stable angina and non-ST-segment elevation acute coronary syndromes who are undergoing percutaneous intervention (PCI). The safety efficacy bivalirudin high-risk unknown.We randomly assigned 3602 ST-segment myocardial infarction presented within 12 hours after onset symptoms were...
Antithrombotic drugs are used after coronary-artery stenting to prevent stent thrombosis. We compared the efficacy and safety of three antithrombotic-drug regimens — aspirin alone, warfarin, ticlopidine coronary stenting.
In clinical trials with sequential patient entry, fixed sample size designs are unjustified on ethical grounds and often impracticable. One solution is a group design dividing entry into number of equal-sized groups so that the decision to stop trial or continue based repeated significance tests accumulated data after each evaluated. Exact results obtained for two treatments normal response known variance. The problem determining required also considered. Simulation shows these may be...