A5013456593- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cardiovascular Function and Risk Factors
- Statistical Methods in Clinical Trials
- Health Systems, Economic Evaluations, Quality of Life
- Musculoskeletal pain and rehabilitation
- Cardiac Imaging and Diagnostics
- Advanced Causal Inference Techniques
- Spine and Intervertebral Disc Pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Patient Satisfaction in Healthcare
- Traumatic Brain Injury and Neurovascular Disturbances
- Matrix Theory and Algorithms
- Total Knee Arthroplasty Outcomes
- Optimal Experimental Design Methods
- Healthcare Systems and Technology
- Cerebrospinal fluid and hydrocephalus
- Natural Products and Biological Research
- Effects of Radiation Exposure
- Mathematical Inequalities and Applications
- Acute Lymphoblastic Leukemia research
- Spinal Dysraphism and Malformations
- Atrial Fibrillation Management and Outcomes
- Peroxisome Proliferator-Activated Receptors
California Adaptive Rowing Program
2019-2023
NewYork–Presbyterian Hospital
2012-2014
Columbia University Irving Medical Center
2012-2014
St. Paul's Hospital
2014
Lenox Hill Hospital
2014
Scripps Clinic
2013
Edwards Lifesciences (United States)
2010-2013
Emory University
2013
New York Hospital Queens
2013
Edwards Lifesciences (Switzerland)
2012-2013
Many patients with severe aortic stenosis and coexisting conditions are not candidates for surgical replacement of the valve. Recently, transcatheter aortic-valve implantation (TAVI) has been suggested as a less invasive treatment high-risk stenosis.
The use of transcatheter aortic-valve replacement has been shown to reduce mortality among high-risk patients with aortic stenosis who are not candidates for surgical replacement. However, the two procedures have compared in a randomized trial involving still
Previous trials have shown that among high-risk patients with aortic stenosis, survival rates are similar transcatheter aortic-valve replacement (TAVR) and surgical replacement. We evaluated the two procedures in a randomized trial involving intermediate-risk patients.
The Placement of Aortic Transcatheter Valves (PARTNER) trial showed that among high-risk patients with aortic stenosis, the 1-year survival rates are similar transcatheter aortic-valve replacement (TAVR) and surgical replacement. However, longer-term follow-up is necessary to determine whether TAVR has prolonged benefits.At 25 centers, we randomly assigned 699 severe stenosis undergo either or TAVR. All were followed for at least 2 years, assessment clinical outcomes echocardiographic...
Transcatheter aortic-valve replacement (TAVR) is the recommended therapy for patients with severe aortic stenosis who are not suitable candidates surgery. The outcomes beyond 1 year in such known.We randomly assigned to transfemoral TAVR or standard (which often included balloon valvuloplasty). Data on 2-year were analyzed.A total of 358 underwent randomization at 21 centers. rates death 2 years 43.3% group and 68.0% standard-therapy (P<0.001), corresponding cardiac 31.0% 62.4% (P<0.001)....
Transcatheter aortic valve implantation was developed to mitigate the mortality and morbidity associated with high-risk traditional replacement. The Edwards SAPIEN approved for transcatheter transfemoral delivery in European Union November 2007 transapical January 2008.The Aortic Bioprosthesis Outcome (SOURCE) Registry designed assess initial clinical results of consecutive patients Europe after commercialization. Cohort 1 consists 1038 enrolled at 32 centers. Patients who were treated...
Smith, Craig R.*; Leon, Martin B.*; Mack, Michael J.†; Miller, D. Craig§; Moses, Jeffrey W.*; Svensson, Lars G.¶; Tuzcu, E. Murat¶; Webb, John G.#; Fontana, Gregory P.**; Makkar, Raj R.**; William, Mathew*; Dewey, Todd‡; Kapadia, Samir¶; Babaliaros, Vasilis††; Thourani, Vinod H.††; Corso, Paul‡‡; Pichard, Augusto D.‡‡; Bavaria, Joseph E.§§; Herrmann, Howard C.§§; Akin, Jodi J.∥; Anderson, William N.∥; Wang, Duolao∥∥; Pocock, Stuart J.∥∥ for the PARTNER (Placement of Aortic Transcatheter...
Outcome studies for spine surgery rely on patient-reported outcomes (PROs) to assess treatment effects. Commonly used health-related quality-of-life questionnaires include the following scales: back pain and leg visual analog scale (BP-VAS LP-VAS); Oswestry Disability Index (ODI); EuroQol-5D health survey (EQ-5D). A shortcoming of these is that their numerical scores lack a direct meaning or clinical significance. Because this, concept minimum clinically important difference (MCID) has been...
Kodali, Susheel K.; Williams, Mathew R.; Smith, Craig Svensson, Lars G.; Webb, John Makkar, Raj Fontana, Gregory P.; Dewey, Todd M.; Thourani, Vinod H.; Pichard, Augusto D.; Fischbein, Michael; Szeto, Wilson Y.; Lim, Scott; Greason, Kevin L.; Teirstein, Paul S.; Malaisrie, S. Chris; Douglas, Pamela Hahn, Rebecca T.; Whisenant, Brian; Zajarias, Alan; Wang, Duolao; Akin, Jodi J.; Anderson, William N.; Leon, Martin B. for the Partner Trial Investigators Author Information
Spine surgery outcome studies rely on patient-reported (PRO) measurements to assess treatment effect, but the extent of improvement in numerical scores these questionnaires lacks a direct clinical meaning. Because this, concept minimum clinically important difference (MCID) has been used measure critical threshold needed achieve relevant effectiveness. As utilization spinal fusion increased over past decade, so incidence same-level recurrent stenosis following index lumbar fusion, which...
Background— The long-term outcomes of transcatheter aortic valve replacement (TAVR) in inoperable patients with severe stenosis remain unknown. Methods and Results— In the Placement Aortic Transcatheter Valves (PARTNER) study, 358 were randomly assigned to TAVR or standard therapy. We report 3-year on these patients, pooled for all (n=449) PARTNER, as well, including randomized portion continued access study (n=91). mortality rate therapy groups was 54.1% 80.9%, respectively ( P <0.001;...
Spinal surgical outcome studies rely on patient-reported (PRO) measurements to assess treatment effect. A shortcoming of these questionnaires is that the extent improvement in their numerical scores lack a direct clinical meaning. As result, concept minimum important difference (MCID) has been used measure critical threshold needed achieve clinically relevant effectiveness. utilization spinal fusion increased over past decade, so incidence adjacent-segment degeneration following index lumbar...
BackgroundThe impact of a new class automated digital patient engagement (DPE) platforms on potentially avoidable costs, hospital admissions, and complications after discharge following hip knee arthroplasties has not been established.MethodsWe conducted multicenter observational cohort study comparing claims data for 90 days at 10 practice sites in CA NV. One hundred eighty-six patients, enrolled between 2014 2016 an DPE platform receiving guidance remote monitoring perioperatively, were...