Nasim Forooghi
A5014540655- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Vascular Procedures and Complications
- vaccines and immunoinformatics approaches
- Cardiac Imaging and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Infection Control and Ventilation
- COVID-19 epidemiological studies
- Advanced X-ray and CT Imaging
- COVID-19 and Mental Health
- Single-cell and spatial transcriptomics
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- SARS-CoV-2 detection and testing
- T-cell and B-cell Immunology
- Gastric Cancer Management and Outcomes
- Long-Term Effects of COVID-19
Barts Health NHS Trust
2020-2024
William Harvey Research Institute
2023-2024
Queen Mary University of London
2023-2024
National Health Service
2024
St Bartholomew's Hospital
2020-2022
Abstract Individuals with potential exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) do not necessarily develop PCR or antibody positivity, suggesting that some individuals may clear subclinical infection before seroconversion. T cells can contribute the rapid clearance of SARS-CoV-2 and other infections 1–3 . Here we hypothesize pre-existing memory cell responses, cross-protective against (refs. 4–11 ), would expand in vivo support viral control, aborting infection....
A boost from infection During clinical trials of severe acute respiratory syndrome coronavirus 2 vaccines, no one who had survived with the virus was tested. year after pandemic declared, vaccination previously infected persons is a reality. Reynolds et al. address knowledge gap in cohort UK health care workers given Pfizer/BioNTech vaccine which half participants experienced natural infections early (see Perspective by Crotty). Genotyping indicated that genetic component underlies...
The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against disease, often attributed to primed cellular immunity. We investigated T B cell immunity B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) different SARS-CoV-2 infection histories....
BackgroundWe hypothesised that host-response biomarkers of viral infections might contribute to early identification individuals infected with SARS-CoV-2, which is critical breaking the chains transmission. We aimed evaluate diagnostic accuracy existing candidate whole-blood transcriptomic signatures for infection predict positivity nasopharyngeal SARS-CoV-2 PCR testing.MethodsWe did a nested case-control study among prospective cohort health-care workers (aged ≥18 years) at St Bartholomew's...
BACKGROUND: Patients with previous coronary artery bypass grafting often require invasive angiography (ICA). However, for these patients, the procedure is technically more challenging and has a higher risk of complications. Observational studies suggest that computed tomography cardiac (CTCA) may facilitate ICA in this group, but not been tested randomized controlled trial. METHODS: This study was single-center, open-label trial assessing benefit adjunctive CTCA patients referred ICA. were...
<ns3:p><ns3:bold>Background</ns3:bold>: Most biomedical research has focused on sampling COVID-19 patients presenting to hospital with advanced disease, less focus the asymptomatic or paucisymptomatic. We established a bioresource serial of health care workers (HCWs) designed obtain samples before and during mainly mild follow-up evaluate quality duration immune memory.</ns3:p><ns3:p> <ns3:bold>Methods</ns3:bold>: conducted prospective study HCWs from three sites in London, initially at...
<ns4:p><ns4:bold>Background</ns4:bold>: Most biomedical research has focused on sampling COVID-19 patients presenting to hospital with advanced disease, less focus the asymptomatic or paucisymptomatic. We established a bioresource serial of health care workers (HCWs) designed obtain samples before and during mainly mild follow-up evaluate quality duration immune memory.</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold>: conducted prospective observational study HCWs from three sites in London,...
Determining the protection an individual has to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VoCs) is crucial for future immune surveillance, vaccine development, and understanding changing response. We devised informative assay current ELISA-based serology using multiplexed, baited, targeted proteomics direct detection multiple proteins in SARS-CoV-2 anti-spike antibody immunocomplex. Serum from individuals collected after infection or first- second-dose...
BACKGROUND: In patients with previous coronary artery bypass grafting, computed tomography cardiac angiography (CTCA) before invasive (ICA) was demonstrated in the BYPASS-CTCA trial (Randomized Controlled Trial to Assess Whether Computed Tomography Cardiac Angiography Can Improve Invasive Coronary Bypass Surgery Patients) reduce procedure time and incidence of contrast-associated acute kidney injury, greater levels patient satisfaction. Patient-related outcomes, utilization further...