A5074207923- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Peripheral Artery Disease Management
- Atherosclerosis and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Hemodynamic Monitoring and Therapy
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Hormonal Regulation and Hypertension
- Adipokines, Inflammation, and Metabolic Diseases
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Cardiomyopathy and Myosin Studies
- Healthcare Systems and Practices
- ECG Monitoring and Analysis
- Mechanical Circulatory Support Devices
- Cardiac, Anesthesia and Surgical Outcomes
- Cell Adhesion Molecules Research
- Heart Failure Treatment and Management
- Cardiovascular and Diving-Related Complications
- Aortic aneurysm repair treatments
Norfolk and Norwich University Hospital
2016-2025
Norfolk and Norwich University Hospitals NHS Foundation Trust
2019-2024
Clinical Trial Investigators
2022
University of East Anglia
2017-2022
Queen Mary University of London
2022
Norwich Research Park
2021
James Paget University Hospital
2014
Westmead Hospital
2008-2009
John Radcliffe Hospital
2007-2008
University of Manchester
2005
BackgroundRemote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown reduce myocardial infarct size in patients ST-elevation infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote could incidence of cardiac death hospitalisation for heart failure at 12 months.MethodsWe did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) 33...
Older people increasingly constitute a large proportion of the acute coronary syndrome (ACS) population. We examined relationship age with receipt more intensive management and secondary prevention medicine. Then, comparative association (reperfusion/angiography) over conservative strategy on time to death was investigated by age. Using data from 155 818 patients in national registry for ACS England Wales [the Myocardial Ischaemia National Audit Project (MINAP)], we found that older were...
The objective of this study is to compare the outcomes patients treated with drug-coated balloons (DCBs) or second-generation drug-eluting stents (DESs) for de novo unprotected left main stem (LMS) disease. Previous studies comparing treatment LMS disease suggest that mortality DES PCI not worse than CABG. There are limited data from investigating DCB angioplasty. We compared all-cause and cardiac paclitaxel those July 2014 November 2019. Data were analysed using Kaplan–Meier analyses...
Plaque erosion causes 30% of ST-segment elevation myocardial infarctions, but the underlying cause is unknown. Inflammatory infiltrates are less abundant in compared with rupture autopsy studies. We hypothesized that and associated significant differences intracoronary cytokines vivo.Forty infarction patients <6 hours chest pain were classified as ruptured fibrous cap (RFC) or intact (IFC) using optical coherence tomography. Plasma samples from infarct-related artery a peripheral analyzed...
Abstract Objectives We aimed to investigate long-term survival of paclitaxel DCB for percutaneous coronary intervention (PCI). Background Safety concerns have been raised over the use devices peripheral artery disease recently, following a meta-analysis suggesting increased late mortality. With regard drug-coated balloon (DCB) angioplasty however, there is limited data date regarding possible mortality relating paclitaxel. Methods compared all-cause patients treated with those non-paclitaxel...
This study examined the effects of sacubitril/valsartan on N-terminal pro–B-type natriuretic peptide (NT-proBNP) levels and determined patient characteristics associated with favorable NT-proBNP reduction response. reflect cardiac wall stress predict event risk in patients acute decompensated heart failure (ADHF). Post-hoc analysis TRANSITION (Comparison Pre- Post-discharge Initiation Sacubitril/Valsartan Therapy HFrEF Patients After an Acute Decompensation Event) study, including stabilized...
We aimed to investigate the safety of drug-coated balloon (DCB)-only angioplasty compared drug-eluting stent (DES), as part routine clinical practice.
Human essential hypertension is characterized by eutrophic remodeling of small arteries, with little evidence hypertrophy. Likewise, vessels young hypertensive TGR(mRen2)27 animals have undergone similar structural alterations. The role integrins in resistance arteries during the eutrophic-remodeling process was examined as blood pressure rose. Initially, 8 alpha and 3 beta were identified levels expression investigated using RT-PCR. As increased advanced, integrin profiles revealed that...
Background: There are no data regarding the outcomes of patients with stent thrombosis (ST) being treated drug-coated balloon (DCB) angioplasty. Our aim was to compare ST DCB vs. a drug eluting (DES). Methods: In this registry analysis, we identified all for in our institution from June 2011 until November 2019. We excluded who died cath lab, uncrossable lesions, and thrombectomy only. Patient were obtained Hospital Episodes Statistics NHS England. The primary endpoint study composite...
ABSTRACT Background and Aims A randomized trial has previously demonstrated that neointimal modification with a scoring balloon improves the anti‐restenotic effect of drug‐coated (DCB) in patients drug‐eluting stent restenosis. There are very limited data about safety efficacy using balloons as part lesion preparation STEMI, especially de novo disease treated DCB‐only angioplasty. Methods We undertook an analysis SPARTAN Norwich Registry to address this question. compared composite endpoint...
Abstract Background Measurement of peak velocities is important in the evaluation heart failure. This study compared performance automated 4D flow cardiac MRI (CMR) with traditional transthoracic Doppler echocardiography (TTE) for measurement mitral inflow diastolic velocities. Methods Patients and magnetic resonance data were included retrospectively. An established technique was used to segment left ventricular transvalvular using short-axis cine stack images. Peak E-wave A-wave...
Platypnea orthodeoxia is a rare syndrome that describes breathlessness on standing resolves lying flat. We present previously healthy patient who developed platypnea in her eighth decade of life. Cardiovascular imaging demonstrated an atrial septal defect, extensive Chiari network and hypertrophy. propose the development lipomatous hypertophy led to altered compliance baffle direct flow preferentially left heart standing.
Aortic conduit and reservoir functions can be directly measured by four-dimensional flow (4D flow) cardiovascular magnetic resonance (CMR).
A 67-year-old cachectic patient presented with a 6-week history of increasing breathlessness, loss weight and appetite. Examination showed peripheral oedema signs cardiac tamponade. Transthoracic echocardiography demonstrated thick walled cystic mass in the anterior pericardium (see online supplementary video 1), compressing right ventricle (RV) atrium (RA). Further evaluation, including bubble contrast echocardiography, suggested haematogenous connection between RA tumour cavity 2). This...