A5069975500- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Vascular Procedures and Complications
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Venous Thromboembolism Diagnosis and Management
- Central Venous Catheters and Hemodialysis
- Cardiac Arrhythmias and Treatments
- Cardiac Health and Mental Health
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Peripheral Artery Disease Management
- Lipoproteins and Cardiovascular Health
- Radiation Dose and Imaging
- Cardiac pacing and defibrillation studies
- Cardiovascular Issues in Pregnancy
- Cardiac Structural Anomalies and Repair
- Healthcare cost, quality, practices
- Advanced X-ray and CT Imaging
- Ultrasound in Clinical Applications
- Acute Kidney Injury Research
Hamilton Health Sciences
2016-2025
McMaster University
2015-2024
Niagara Health System
2022-2023
Hamilton General Hospital
2006-2022
Population Health Research Institute
2005-2022
Université Laval
2018
Toronto Public Health
2014-2015
Institute for Clinical Evaluative Sciences
2009-2015
University of Toronto
2009-2015
Sunnybrook Health Science Centre
2009-2015
Guidelines recommend that noncardiac surgery be delayed until 30 to 45 days after bare-metal stent implantation and 1 year drug-eluting implantation.We used linked registry data population-based administrative health care databases conduct a cohort study of 8116 patients (≥40 years age) who underwent major elective in Ontario, Canada between 2003 2009, received coronary stents within 10 before surgery. Approximately 34% (n=2725) insertion 2 surgery, whom 905 (33%) stents. For comparison, we...
The aim of this study was to determine the effects advanced chronic kidney disease (CKD) on early and late outcomes after transcatheter aortic valve implantation (TAVI), evaluate predictive factors poorer in such patients.This a multicentre including total 2075 consecutive patients who had undergone TAVI. Patients were grouped according estimated glomerular filtration rate as follows: CKD stage 1-2 (≥60 mL/min/1.73 m(2); n = 950), 3 (30-59 924), 4 (15-29 134) 5 (<15 m² or dialysis; 67)....
Importance A significant limitation of femoral artery access for cardiac interventions is the increased risk vascular complications and bleeding compared with radial access. Strategies to make safer are needed. Objective To determine whether routinely using ultrasonography guidance arterial coronary angiography/intervention reduces or complications. Design, Setting, Participants The Routine Ultrasound Guidance Vascular Access Cardiac Procedures (UNIVERSAL) randomized clinical trial a...
In patients with ST-segment elevation myocardial infarction (STEMI), early initiation of high-intensity statin therapy, regardless low-density lipoprotein (LDL) cholesterol levels, is the standard practice worldwide. Aims: We sought to determine effect a similar strategy, using proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor added statin, on LDL in acute STEMI.In randomised, double-blind trial we assigned 68 STEMI undergoing primary percutaneous coronary intervention (PCI)...
Background— Factor Xa plays a central role in the generation of thrombin, making it novel target for treatment arterial thrombosis. Fondaparinux is synthetic factor inhibitor that has been shown to be superior standard therapies prevention venous We performed randomized trial determine safety and feasibility fondaparinux percutaneous coronary intervention (PCI) setting. Methods Results— A total 350 patients undergoing elective or urgent PCI were blinded manner receive unfractionated heparin...
Background Despite evidence of high heritability, monogenic disorders are identified in a minor fraction individuals with early-onset coronary artery disease (EOCAD). We hypothesized that some EOCAD carry number common genetic risk variants, combined effect similar to Mendelian forms disease, such as familial hypercholesterolemia. Methods and Results To confirm the polygenic contribution (age ≤40 years for men ≤45 women), we calculated 111 418 British participants from UK Biobank cohort...
Interventional cardiologists receive one of the highest levels annual occupational radiation exposure. Further measures to protect healthcare workers are needed.We evaluated efficacy a pelvic lead shield and novel surgical cap in reducing operators' Patients undergoing coronary angiography or percutaneous intervention (n=230) were randomized have their procedure with without (Ultraray Medical, Oakville, Canada) placed over patient. During all procedures, operators wore No Brainer (Worldwide...
Whether ultrasound (US)-guided femoral access compared to without US guidance decreases site complications in patients receiving a vascular closure device (VCD) is unclear.
Background: Manifestations of cardiac amyloidosis may include congestive heart failure and sudden death. Although vascular involvement in patients with is common, systemic presenting angina rare. Objectives: To report on pectoris. Design: Case series. Setting: Academic medical center. Patients: Five who presented pectoris normal coronary angiogram as the initial manifestation amyloidosis. Measurements: Endothelial-dependent endothelialindependent flow reserve. Results: All had reserve...