A5062465541- Breast Implant and Reconstruction
- Reconstructive Surgery and Microvascular Techniques
- Radiopharmaceutical Chemistry and Applications
- Breast Cancer Treatment Studies
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Acute Myocardial Infarction Research
- Advanced Proteomics Techniques and Applications
- Diversity and Career in Medicine
- Cardiac Imaging and Diagnostics
- Mass Spectrometry Techniques and Applications
- Coronary Interventions and Diagnostics
- Heart Rate Variability and Autonomic Control
- Body Contouring and Surgery
- Cancer Immunotherapy and Biomarkers
- COVID-19 and healthcare impacts
- HER2/EGFR in Cancer Research
- Ubiquitin and proteasome pathways
- Advances in Oncology and Radiotherapy
- Acute Lymphoblastic Leukemia research
- Monoclonal and Polyclonal Antibodies Research
- Digital Imaging in Medicine
- Cardiac Health and Mental Health
- Reconstructive Facial Surgery Techniques
University of California, Los Angeles
2022-2025
Precision Nanosystems (Canada)
2022-2024
The University of Texas Medical Branch at Galveston
2019-2023
Creative Commons
2016-2022
University of British Columbia
2014-2019
British Columbia Centre of Excellence for Women's Health
2019
University of Chicago
2011-2018
Centre for Advancing Health Outcomes
2014-2018
University of Alberta
2018
Singer (United States)
2017
Background: Fat transfer is an increasingly popular method for refining postmastectomy breast reconstructions. However, concern persists that fat may promote disease recurrence. Adipocytes are derived from adipose-derived stem cells and express adipocytokines can facilitate active cancer in laboratory models. The authors sought to evaluate the association between reconstructed recurrence patients diagnosed with local or regional invasive cancers. Methods: A multicenter, case-cohort study was...
Systolic and diastolic blood pressure thresholds, below which cardiovascular events increase, are widely debated. Using data from the SPRINT (Systolic Blood Pressure Intervention Trial), we evaluated relation between systolic among 1519 participants with or 7574 without prior disease. Cox regression, examined composite risk of myocardial infarction, other acute coronary syndrome, stroke, heart failure, death, follow-up were analyzed as time-dependent covariates for a median 3.1 years. Models...
The best secondary option for autologous breast reconstruction remains controversial. Limitations of the gracilis myocutaneous flap, including volume, skin paddle reliability, and donor morbidity, have been addressed by several modifications, hereby expanding its role in decision tree reconstruction. This report documents authors' experience with flap reconstruction.This is a retrospective case series prospectively maintained database patients undergoing free transverse upper gracilis,...
Summary Mantle cell lymphoma (MCL) after relapse is associated with poor prognosis. No standard of care exists and available evidence for treatments limited, particularly in patients who fail Bruton tyrosine kinase inhibitor (BTKi) therapy. This multicentre retrospective chart review study, SCHOLAR‐2, addresses this knowledge gap reports on data collected from 240 relapsed/refractory MCL Europe were treated BTKi‐based therapy between July 2012 2018, had experienced disease progression while...
Background: Refinements in microsurgical breast reconstruction have refined superficial inferior epigastric artery (SIEA) and circumflex iliac (SCIA) flaps, yet technical difficulties varied success rates limit widespread acceptance. The authors present the outcomes of their experience with 145 consecutive SIEA/SCIA flaps suggest tips to improve this important flap. Methods: An institutional review board–approved retrospective chart all free performed by senior between January 1, 2006,...
Background: Trauma patients with high-energy injuries often present severe tissue damage that extends beyond the immediate zone of injury and requires recruitment vascularized tissues from distant sites. The objective this study was to evaluate utility anterolateral thigh (ALT) flap for reconstruction traumatically injured lower extremity. Methods: Prospective data were collected on all who underwent extremity an ALT during a 3.5-year period at primary adult resource center (PARC)....
e15133 Background: Leucine-Rich Repeat-Containing Protein 15 (LRRC15), a TGFβ-regulated antigen, is prominently expressed in mesenchymal-derived cancer cells and cancer-associated fibroblasts (CAFs) within aggressive, immune-excluded, treatment-resistant tumors. In response to these challenges, we developed an LRRC15-targeted radioimmunotheranostic compound designed for molecularly specific, non-invasive imaging therapy. To fully leverage this technology, our goal was identify the genomic...
For patients with small breasts relative to tumor size and for those tumors in the central or inferior poles, lumpectomy can be aesthetically devastating. The field of oncoplastic surgery has developed offset aesthetic pitfalls breast conservation. Questions remain regarding oncologic safety, potential complications, patient selection. In this study, we report our institutional, multidisciplinary experience surgery.A retrospective review was performed including all at institution undergoing...
Sir: Social media have become a dominant force in today’s world. Nearly 3 billion monthly active users use social to connect with family, friends, those shared interests, and society at large. In addition, are integral the dissemination of information, education, advertisements. Within field plastic surgery, impact is significant.1 Plastic surgeons them as marketing tools, promote research, colleagues, create brand.2 The within surgery has several benefits. Educational materials disseminated...
Using 3‐D searching techniques based on algorithms derived from graph theory we have established a striking structural similarity between the structure or bovine carboxypeptidase A and that of C‐terminal domain leucine aminopeptidase. There is no significant sequence homology aminopeptidases carboxypeptidases but strong relationship detected in this complex fold suggests there may be very remote divergent evolutionary these two enzyme classes.
Impostor phenomenon occurs when high-achieving individuals have persistent self-doubt despite objective measures of competence and success, has been associated with professional burnout attenuated career advancement in medical specialties. This study aimed to define the incidence severity impostor academic plastic surgery.
ABSTRACT Leucine-rich repeat containing 15 (LRRC15) has emerged as an attractive biomarker and target for cancer therapy. We have developed a humanized monoclonal antibody (mAb), DUNP19, that specifically binds to phylogenetically conserved LRRC15 epitope is internalized by target-expressing stromal cells. In xenograft mouse models, Lutetium-177 labeled DUNP19 ([ 177 Lu]-DUNP19) enables non-invasive imaging precise radiotherapy LRRC15-expressing cells murine cancer-associated fibroblasts...
The SCHOLAR-2 retrospective study highlighted poor overall survival (OS) with standard of care (SOC) regimens among patients relapsed/refractory (R/R) mantle cell lymphoma (MCL) who failed a covalent Bruton tyrosine kinase inhibitor (BTKi). In the ZUMA-2 single-arm trial, brexucabtagene autoleucel (brexu-cel; autologous anti-CD19 CAR T-cell therapy) demonstrated high rates durable responses in R/R MCL had previous BTKi exposure. Here, we compared OS and using three different methods which...
Ranolazine is approved in the United States and Europe for chronic stable angina. Microvascular angina (MVA) defined as with no obstructive coronary artery disease.Our objective was to assess effectiveness of ranolazine at improving scores quality life a Canadian cohort severe refractory due MVA.We administered questionnaires 31 patients baseline after least 6 weeks treatment.Validated, clinically significant changes each Seattle Angina Questionnaire domain Quality Life Enjoyment...