A5086240813- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Infective Endocarditis Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Aortic aneurysm repair treatments
- Peripheral Artery Disease Management
- Vascular Procedures and Complications
- Coronary Artery Anomalies
- Aortic Disease and Treatment Approaches
- Atrial Fibrillation Management and Outcomes
- Kawasaki Disease and Coronary Complications
- Cardiac pacing and defibrillation studies
- Venous Thromboembolism Diagnosis and Management
- Atherosclerosis and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebral Venous Sinus Thrombosis
- Intracranial Aneurysms: Treatment and Complications
- Elasticity and Material Modeling
- Telomeres, Telomerase, and Senescence
- Cardiac tumors and thrombi
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
Papworth Hospital
2015-2025
Papworth Hospital NHS Foundation Trust
2011-2025
University of Cambridge
2007-2023
Brigham and Women's Hospital
2023
Addenbrooke's Hospital
2007-2019
Imperial College Healthcare NHS Trust
2014-2017
EMO GVM Centro Cuore Columbus
2013-2016
Vita-Salute San Raffaele University
2013-2016
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2016
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2013-2016
Transcatheter aortic-valve implantation (TAVI) is associated with procedure-related stroke. Cerebral embolic protection (CEP) devices may reduce embolization to the cerebral circulation and hence incidence of We conducted a randomized, controlled trial across 33 centers in United Kingdom. randomly assigned 7635 participants aortic stenosis 1:1 ratio undergo TAVI CEP device (CEP group) or without (control group). The primary outcome was stroke within 72 hours after before discharge from...
Background— Although rupture of thin-cap fibroatheroma (TCFA) underlies most myocardial infarctions, reliable TCFA identification remains challenging. Virtual-histology intravascular ultrasound (VH-IVUS) and optical coherence tomography (OCT) can assess tissue composition classify plaques. However, direct comparisons between VH-IVUS OCT are lacking it unknown whether combining these modalities improves identification. Methods Results— Two hundred fifty-eight regions-of-interest were obtained...
Abstract Aims The focal distribution of atherosclerotic plaques suggests that local biomechanical factors may influence plaque development. Methods and results We studied 40 patients at baseline over 12 months by virtual-histology intravascular ultrasound bi-plane coronary angiography. calculated structural stress (PSS), defined as the mean maximum principal peri-luminal region, wall shear (WSS), parallel frictional force exerted blood flow on endothelial surface, in areas undergoing...
The aim of this study was to identify the determinants plaque structural stress (PSS) and relationship between PSS plaques with rupture.Plaque rupture is most common cause myocardial infarction, occurring particularly in higher risk lesions such as fibroatheromas. However, prospective intravascular ultrasound-virtual histology studies indicate that <10% clinical events over 3 years, indicating other factors also determine rupture. Plaque occurs when exceeds its mechanical strength; however,...
Although plaque rupture is responsible for most myocardial infarctions, few high-risk plaques identified by intracoronary imaging actually result in future major adverse cardiovascular events (MACE). Nonimaging markers of individual behavior are therefore required. Rupture occurs when structural stress (PSS) exceeds material strength. We assessed whether PSS could predict MACE nonculprit lesions on virtual-histology intravascular ultrasound.Baseline lesion features associated with during...
Leukocyte telomere length (LTL), a marker of cellular senescence, is inversely associated with cardiovascular events. However, whether LTL reflects plaque extent or unstable plaques, and the mechanisms underlying any association are unknown.One hundred seventy patients stable angina acute coronary syndrome referred for percutaneous intervention underwent 3-vessel virtual histology intravascular ultrasound; 30 372 mm ultrasound pullback 1096 plaques were analyzed. was not volume but calcified...
To compare the early clinical outcomes between ABSORB bioresorbable vascular scaffold (BVS) (Abbott Vascular, Santa Clara, CA) and cobalt chromium everolimus-eluting stents in real-world patients with mostly complex disease.BVS represents most interesting development drug-eluting stent field over recent years promising results emerging from trials. Available data however on use of is limited.All (n = 92) treated BVS 1296 EES were included this study. Propensity score matching was performed...
This study sought to determine if plaque structural stress (PSS) and other parameters are increased in plaques that cause future major adverse cardiovascular event(s) (MACE) incorporating these improves predictive capability of intravascular ultrasonography (IVUS).Less than 10% coronary identified as high-risk by imaging result subsequent MACE. Thus, more specific measurements vulnerability required for effective risk stratification.Propensity score matching the PROSPECT (Providing Regional...
Anatomical imaging alone of coronary atherosclerotic plaques is insufficient to identify risk future adverse events and guide management non-culprit lesions. Low endothelial shear stress (ESS) high plaque structural (PSS) are associated with events, but individually their predictive value for prediction. We determined whether combining multiple complementary, biomechanical anatomical characteristics improves outcome prediction sufficiently inform clinical decision-making.
Abstract Background ProGlide is a percutaneous suture‐mediated closure device used in arterial and venous following intervention. Risk of vascular complications from use, particularly related to failure hemostasis, or acute vessel closure, remains significant often improper suture deployment. We describe technique ultrasound‐guided deployment transfemoral transcatheter aortic valve implantation (TF‐TAVI). Aims The aim this study assess outcomes for devices patients undergoing TF‐TAVI....
To report clinical outcomes in patients treated with drug-eluting balloon (DEB) versus second-generation stent (DES) for in-stent restenosis (ISR) involving a bifurcation lesion.Between February 2007 and November 2012, 167 restenoses 158 were either DEB (n=73) or DES (n=85). The EuroSCORE was significantly higher the group (4.2±3.8 vs. 2.8±2.1, p=0.004). Regarding restenosed type, more frequently seen (26.9% 6.7%, p<0.001). In this group, there also trend towards frequent stenting previous...
Objectives To compare the long‐term clinical outcomes of paclitaxel drug‐coated‐balloons (DCB) and everolimus‐eluting‐stents (EES) following treatment de novo small vessel coronary artery disease. Background It is currently unclear whether disease with DCB comparable to second generation drug‐eluting stents, which are current standard care. Methods The present study enrolled 90 patients from arm BELLO (Balloon Elution Late Loss Optimization) trial 2,000 treated EES at San Raffaele Scientific...