A5005852503- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- Cardiac Arrhythmias and Treatments
- Vascular Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Lipoproteins and Cardiovascular Health
- Cardiac Fibrosis and Remodeling
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Atherosclerosis and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Central Venous Catheters and Hemodialysis
- Cardiac Valve Diseases and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular Disease and Adiposity
- Immune Response and Inflammation
- Cerebrovascular and Carotid Artery Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Cardiac Structural Anomalies and Repair
Wellington Hospital
2016-2025
Victoria University of Wellington
2012-2024
Capital and Coast District Health Board
2011-2022
University of Otago
2014-2022
Harding University Main Campus
2021
University of Lisbon
2021
University of Edinburgh
2006-2016
Royal Perth Hospital
2014
British Heart Foundation
2013
Edinburgh Royal Infirmary
2001-2010
Noncardiac surgery performed after coronary stent implantation is associated with an increased risk of thrombosis, myocardial infarction, and death. The influence type period still have to be defined.We linked the Scottish Coronary Revascularisation Register hospital admission data undertake a Scotland-wide retrospective cohort study examining cardiac outcomes in all patients who received drug-eluting or bare-metal stents between April 2003 March 2007 subsequently underwent noncardiac...
Intravenous ribavirin was provided non-selectively for investigational open-label use among persons with suspected hantavirus pulmonary syndrome (HPS) in the United States between 4 June 1993 and 1 September 1994. Therapy initiated prior to laboratory confirmation of infection because most deaths from HPS occur within 48 h hospitalization. Thirty patients confirmed HPS, 105 without 5 adequate diagnostic testing were enrolled. This observational study arguably provides complete information...
The inflammatory cytokine, tumour necrosis factor α (TNF-α), exerts deleterious cardiovascular effects. We wished to determine the effects of TNF-α antagonism on endothelial function and platelet activation in patients with acute myocardial infarction.A double-blind, parallel group, randomised controlled trial performed a tertiary referral cardiac centre. 26 presenting infarction receive an intravenous infusion etanercept (10 mg) or saline placebo.Leucocyte count, plasma cytokine...
Multiple sclerosis (MS) is an immune‐driven, demyelinating disease of the central nervous system (CNS). Although many types immune cells are involved in progression, activated monocytes believed to be one first arrive brain and initiate inflammation. However, little known about how two main monocyte subsets, CD14 ++ CD16 − + , MS. To understand phenotype responses these subsets altered during MS, total purified from healthy subjects ( n =29) MS patients =20) were characterized ex vivo...
Background— Smoking is a potent cardiovascular risk factor and associated with proinflammatory prothrombotic responses. The CD40/CD40 ligand (CD40L) dyad platelet-monocyte aggregation mediate range of processes thought to be important in atherothrombosis. We investigated whether expression the CD40/CD40L are altered cigarette smokers. Methods Results— C-reactive protein (CRP), soluble (s) CD40L, surface CD40L on platelets T cells CD40 monocytes aggregates were compared 25 smokers age-...
Activation of both platelets and neutrophils can contribute to the risk major adverse cardiovascular events (MACE) following acute myocardial infarction (AMI). Neutrophil extracellular traps (NETs) are an important product platelet-neutrophil axis exaggerate vascular damage in disease. Additionally, activated drive NETosis directly linked thromboembolic risk. Investigating combined effect biomarkers for platelet activation represents a novel approach prediction post-AMI. Here, we examined...
Abstract Contrast‐induced nephropathy (CIN) is a common complication of cardiac catheterization, reported to result in 15% incidence acute renal failure. Convincing evidence supports the prophylactic use prehydration and low volumes contrast medium. Recently, antioxidant acetylcysteine has been shown have potential preventive role. The aim this study was examine hypothesis that prevents CIN. Patients undergoing catheterization with serum creatinine ≥ 1.5 mg/dl were prospectively randomized...
Platelet-monocyte aggregates are increasingly being used to quantify platelet activation. The variables that influence platelet-monocyte have not been well defined. We sought determine the effect of blood collection, handling and processing techniques on detected levels using a flow cytometric assay. Whole was labelled with anti-CD14-PE anti-CD42a-FITC. Thereafter, samples were fixed red cells lysed. Analysis performed cytometer initially triggering light scatter then FL-2 identify CD14-PE...
The use of a retrograde approach and algorithm-driven CTO (chronic total occlusion) percutaneous coronary intervention (PCI) has become widespread, many registries have reported good results. This study established new algorithm applied it to current practice collected registry document the It compared outcomes versus antegrade in contemporary multicentre registry.Between 1 January 2016 31 December 2016, consecutive patients who underwent PCI performed by eight high-volume operators were...
<h3>Objective</h3> The effects of ω-3 fatty acids on endothelial function, fibrinolysis and platelet function are uncertain. We investigated the acid supplementation vasomotor endogenous fibrinolysis, monocyte activation in healthy cigarette smokers; a group at increased risk myocardial infarction. <h3>Design, setting, participants</h3> Twenty smokers were recruited into randomised, double-blind, placebo-controlled, crossover trial supplementation. <h3>Intervention</h3> supplements (2 g/day)...
Factors affecting the Multiplate® assay's analytical precision have not been well defined. We investigated effect of methodological factors on measurement ADP-induced platelet aggregation using assay. was analysed in whole blood tested reproducibility measurement, different anticoagulants (hirudin, citrate and heparin) time delay (15, 30, 45, 60, 120 180 minutes) between sampling analysis patients. The use a manual calibrated pipette with analyser also tested. mean coefficient variation (CV)...