A5043868001- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- HIV Research and Treatment
- Viral Infections and Vectors
- Myasthenia Gravis and Thymoma
- Viral Infections and Outbreaks Research
- Peripheral Neuropathies and Disorders
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Reproductive tract infections research
- Cytomegalovirus and herpesvirus research
- Cancer Treatment and Pharmacology
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- interferon and immune responses
- Female Genital Mutilation/Cutting Issues
- Cultural Insights and Digital Impacts
- Pharmaceutical industry and healthcare
- Respiratory viral infections research
- Healthcare cost, quality, practices
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Influenza Virus Research Studies
NHS Greater Glasgow and Clyde
2018-2024
Glasgow Royal Infirmary
2015-2021
Queen Elizabeth University Hospital
2019
Gartnavel General Hospital
2011-2018
Wisconsin Department of Agriculture Trade and Consumer Protection
2009
Pocatello High School
1999
United States Food and Drug Administration
1999
The University of Texas Health Science Center at San Antonio
1996
Credit Suisse (Switzerland)
1985
An outbreak of acute hepatitis unknown aetiology in children was reported Scotland1 April 2022 and has now been identified 35 countries2. Several recent studies have suggested an association with human adenovirus this outbreak, a virus not commonly associated hepatitis. Here we report detailed case–control investigation find between adeno-associated 2 (AAV2) infection host genetics disease susceptibility. Using next-generation sequencing, PCR reverse transcription, serology situ...
Intravenous ribavirin was provided non-selectively for investigational open-label use among persons with suspected hantavirus pulmonary syndrome (HPS) in the United States between 4 June 1993 and 1 September 1994. Therapy initiated prior to laboratory confirmation of infection because most deaths from HPS occur within 48 h hospitalization. Thirty patients confirmed HPS, 105 without 5 adequate diagnostic testing were enrolled. This observational study arguably provides complete information...
ObjectivesTravel-associated infections are challenging to diagnose because of the broad spectrum potential aetiologies. As a proof-of-principle study, we used MNGS identify viral pathogens in clinical samples from returning travellers single center explore its suitability as diagnostic tool.MethodsPlasma 40 presenting with fever ≥38°C were sequenced using on Illumina MiSeq platform and compared standard-of-care assays.ResultsIn total, 11/40 patients diagnosed infection. Standard care...
Summary paragraph An outbreak of acute hepatitis unknown aetiology in children was first reported Scotland April 2022. 1 Cases aged <16 years have since been identified 35 countries. 2 Here we report a detailed investigation 9 early cases and 58 control subjects. Using next-generation sequencing real-time PCR, adeno-associated virus (AAV2), detected the plasma 9/9 liver 4/4 patients but 0/13 sera/plasma age-matched healthy controls, 0/12 with adenovirus (HAdV) infection normal function...
Harm reduction has dramatically reduced HIV incidence among people who inject drugs (PWID). In Glasgow, Scotland, <10 infections/year have been diagnosed PWID since the mid-1990s. However, in 2015 a sharp rise diagnoses was noted PWID; many were subtype C with 2 identical drug-resistant mutations and some displayed low avidity, suggesting infections linked recent.We collected Scottish pol sequences identified closely related from public databases. Genetic linkage ascertained 228 Scottish,...
Abstract Background In October 2015, 65 people came into direct contact with a healthcare worker presenting late reactivation of Ebola virus disease (EVD) in the United Kingdom. Vaccination was offered to 45 individuals an initial assessment high exposure risk. Methods Approval for rapid expanded access recombinant vesicular stomatitis virus–Zaire (rVSV-ZEBOV) vaccine as unlicensed emergency medicine obtained from relevant authorities. An observational follow-up study carried out 1 year...
Myasthenia gravis (MG) is an antigen-specific autoimmune disease caused by antibodies against acetylcholine receptors (AChR) at the post-synaptic membrane of neuromuscular junction. Clinical and immunological data imply involvement AChR-specific T lymphocytes as helper cells for autoantibody production. Direct to support this hypothesis, however, remain sparse. In present study, a large population MG patients was studied evidence peripheral blood cell activation several assays. Assays based...
Abstract Background Lookback investigations are conducted by blood services when a risk of transmission infection from donor to recipient has been identified. They involve tracing transfusion recipients and offering them testing for the relevant infectious agent. Results relayed provide reassurance that there no or ensure appropriate treatment care if required, able learn lessons planning, delivery, outcomes investigation. A national lookback exercise was in Scotland following introduction...
HIV-1 infects an estimated 37 million people worldwide, while the rarer HIV-2 1-2 worldwide. is mainly restricted to West African countries. The majority of patients in Scotland are diagnosed with HIV-1, but 2013 Specialist Virology Centre (WoSSVC) Scotland's first positive case a patient from Côte d'Ivoire. differs terms structural viral proteins, transmissibility, prolonged period latency, intrinsic resistance certain antivirals and how monitor effectiveness treatment. Over course 5 years...
Journal Article Corrected proof Scientific Business Abstracts Get access Keith Siew, Siew University College London, United Kingdom Search for other works by this author on: Oxford Academic PubMed Google Scholar Vaksha Patel, Patel Jasminka Zimmermann, Zimmermann Michael Vaughan, Vaughan of Cork, Eire Christopher Cheshire, Cheshire Crick Institute, Angela Kubik, Kubik NASA Ames Research Centre, USA Rebecca Finch, Finch Staffordshire, Zhongwang Li, Li Selin Altinok, Altinok North Carolina,...
A man in his sixth decade presented to General Practitioner with a several week history of myalgia and generalized malaise. His blood count was notable for leukocytosis lymphocyte 24 × 109/L but otherwise normal. peripheral film demonstrated smear cells numerous atypical lymphocytes including medium large bilobed or convoluted nuclei, granular lymphocytes, some which were unusually also had irregular nuclei; the showed varying degree cytoplasmic basophilia, sometimes (images ×100 objective)....
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Myasthenia gravis (MG) is an antigen-specific autoimmune disease caused by antibodies against acetylcholine receptors (AChR) at the post-synaptic membrane of neuromuscular junction. Clinical and immunological data imply involvement AChR-specific T lymphocytes as helper cells for autoantibody production. Direct to support this hypothesis, however, remain sparse. In present study, a large population MG patients was studied evidence peripheral blood cell activation several assays. Assays based...