A5058048925- Substance Abuse Treatment and Outcomes
- Alcohol Consumption and Health Effects
- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Poverty, Education, and Child Welfare
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Transcranial Magnetic Stimulation Studies
- Hydrogen Storage and Materials
- Decision-Making and Behavioral Economics
- Ammonia Synthesis and Nitrogen Reduction
- Schizophrenia research and treatment
- Child Nutrition and Water Access
- Asymmetric Hydrogenation and Catalysis
- Neuroscience and Neuropharmacology Research
- Alcoholism and Thiamine Deficiency
- Neurological disorders and treatments
- Neural and Behavioral Psychology Studies
- Neuroscience of respiration and sleep
- Prenatal Substance Exposure Effects
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Nicotinic Acetylcholine Receptors Study
- Organoboron and organosilicon chemistry
- Homelessness and Social Issues
University of Toronto
2006-2025
Centre for Addiction and Mental Health
2020-2025
The Scarborough Hospital
2022-2025
Mathematica Policy Research
2012-2025
Yale University
2019-2024
Canada Research Chairs
2020-2024
Mental Health Research Canada
2023-2024
VA Connecticut Healthcare System
2019-2024
Connecticut Mental Health Center
2024
Mental Health Research Institute
2023
The catalytic dehydrocoupling/dehydrogenation of N-methylamine-borane, MeNH(2)·BH(3) (7), to yield the soluble, high molecular weight poly(N-methylaminoborane) (8a), [MeNH-BH(2)](n) (M(W) > 20 000), has been achieved at °C using Brookhart's Ir(III) pincer complex IrH(2)POCOP (5) (POCOP = [μ(3)-1,3-(OPtBu(2))(2)C(6)H(3)]) as a catalyst. analogous reaction with ammonia-borane, NH(3)·BH(3) (4), gave an insoluble product, [NH(2)-BH(2)](n) (8d), but copolymerization soluble random copolymers,...
Importance Cannabis use has increased globally, but its effects on brain function are not fully known, highlighting the need to better determine recent and long-term activation outcomes of cannabis use. Objective To examine association lifetime history heavy with across a range functions in large sample young adults US. Design, Setting, Participants This cross-sectional study used data (2017 release) from Human Connectome Project (collected between August 2012 2015). Young (aged 22-36 years)...
We analyzed data from a survey of occupational factors and pregnancy outcome to examine the effects cigarette, alcohol, coffee consumption on outcome. Clear statistically significant associations were found between cigarette alcohol spontaneous abortion. There was weaker but association with consumption: If casual, 11% abortions could be attributed smoking, 5% 2% coffee.
The efficient catalytic dehydrocoupling of a range amine-borane adducts, R'RNH x BH(3) (R' = R Me 1a; R' (i)Pr 1b; Me, CH(2)Ph 1c) by series group 4 metallocene type precatalysts has been demonstrated. A reduction in activity was detected upon descending the and also on substitution cyclopentadienyl (Cp) ligands with sterically bulky or electron-donating substituents. Precatalysts Cp(2)TiCl(2)/2(n)BuLi Cp(2)Ti(PMe(3))(2), which are believed to act as precursors [Cp(2)Ti], were found promote...
We analyzed data from a survey of occupational and other factors in pregnancy to assess the effects cigarette, alcohol, coffee consumption on outcome. The risk low birth weight for gestational age was found increase substantially with smoking. Occasional consumers alcohol had slightly reduced relative total abstainers. In more frequent drinkers, there small risk. Risk increased consumption.
Although several risk factors have been identified for alcohol use disorder, many individuals with these do not go on to develop the disorder. Identifying early phenotypic differences between vulnerable and healthy control subjects could help identify those at higher risk. Binge drinking, defined as reaching a blood level of 80 mg%, carries negative legal health outcomes may be an marker vulnerability. Using carefully controlled experimental paradigm, authors tested hypothesis that including...
We evaluate the long-term effects of a “girl-friendly” primary school program in Burkina Faso, using regression discontinuity design. Ten years later, school-age children villages selected for attend more often and score significantly higher on standardized tests. also find academic social outcomes exposed earlier program. Secondary-school–age youths young adults (those old enough to have finished secondary school) complete at rates perform better Women completed delay both marriage childbearing.
Intravenous ribavirin was provided non-selectively for investigational open-label use among persons with suspected hantavirus pulmonary syndrome (HPS) in the United States between 4 June 1993 and 1 September 1994. Therapy initiated prior to laboratory confirmation of infection because most deaths from HPS occur within 48 h hospitalization. Thirty patients confirmed HPS, 105 without 5 adequate diagnostic testing were enrolled. This observational study arguably provides complete information...
The Rh(I) complex RhCl(PHCy(2))(3) (1) (Cy = cyclohexyl, C(6)H(11)) has been investigated as a catalyst for the dehydrogenation/dehydrocoupling of dimethylamine-borane adduct Me(2)NH.BH(3) (3) at 20 degrees C to afford cyclic dimer [Me(2)N-BH(2)](2) (4). Unlike previously studied neutral and cationic precatalysts such [{Rh(mu-Cl)(1,5-cod)}(2)] [Rh(1,5-cod)(2)]OTf (1,5-cod 1,5-cyclooctadiene, C(8)H(12), OTf OSO(2)CF(3)) with weakly electron-donating ligands metal center, which are reduced...
Complexes of Group 4 metallocenes in the +3 oxidation state and amidoborane or phosphidoborane function as efficient precatalysts for dehydrocoupling/dehydrogenation amine-boranes, such Me(2) NH⋅BH(3). Such Ti(III) -amidoborane complexes are generated [Cp(2)Ti]-catalyzed amine-borane dehydrocoupling reactions, which diamagnetic M(II) M(IV) species have been previously postulated intermediates.
We analyzed data from a survey of occupational and other factors pregnancy outcome to assess the effects cigarette, alcohol, coffee consumption. There was no evidence an association between any congenital defect smoking. Results for alcohol consumption were largely negative, but there weak with musculoskeletal defects in babies born women who drank one or more alcoholic drinks day.
Abstract The endocannabinoid system plays an important role in reward and addiction. One of the two main neurotransmitters, anandamide, is metabolized by fatty acid amide hydrolase, enzyme with a functional genetic polymorphism ( FAAH Pro129Thr, rs324420). Thr129 allele has been linked to problem drug alcohol use, but association not widely replicated may be stronger for clinical measures severity rather than categorical diagnosis. In present study, we sought determine whether was associated...
Few studies have assessed the relation between dietary patterns and gastric adenocarcinoma risk, yet this approach has advantages over single-nutrient analysis, including ability to reflect eating in populations ease of implementing recommendations. The authors evaluated associations patterns, a food index score, incident cancer risk Canadian study 1,169 cases 2,332 controls (1995–1997). Dietary were via factor analysis applied frequency questionnaire. A score was derived based on factors...
We evaluate the causal effects of a program that constructed high quality "girl-friendly" primary schools in Burkina Faso, using regression discontinuity design 2.5 years after started. find increased enrollment all children between ages 5 and 12 by 20 percentage points their test scores 0.45 standard deviations. The change for those caused to attend school is 2.2 also was particularly effective girls, increasing rate more than boys', although this did not translate into differential effect...
Background Alcohol use disorder ( AUD ) has been associated with impairments in cognitive and emotional function, including difficulty identifying facial expressions. However, it is unclear whether these deficits are alcohol consumption or related anxious depressive symptoms. Methods We compared the recognition of faces expressing happiness, surprise, sadness, fear, anger, disgust 19 participants healthy volunteers using Cambridge Neuropsychological Test Automated Battery Emotion Recognition...
BACKGROUND: This historical cohort study was conducted to examine the relationship between gynaecological surgery and ovarian cancer risk. METHODS: Women were included if they had tubal ligation, hysterectomy, or unilateral ovariectomy in Ontario March 1979 April 1993. The linked Cancer Registry mortality file. Person-years accumulated until death, removal of both ovaries, a diagnosis cancer, end period 31 December Observed cancers compared expected based on age- calendar period-specific...
Nonsteroidal antiinflammatory drugs (NSAIDs) may play a role in breast cancer prevention; however, subtypes and lifestyle/host factors influence their impact. During 1996-1998 Canada, the authors examined association between regular NSAID use (defined as daily for at least 2 months) risk by estrogen receptor (ER) progesterone (PR) status, cigarette smoking exposure, history of arthritis. Breast cases (n = 3,125, including 1,600 ER+PR+ 591 ER-PR-) an age-matched, random sample controls 3,062)...